ID   TM9S1_RAT               Reviewed;         589 AA.
AC   Q66HF2;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Transmembrane 9 superfamily member 1;
DE   Flags: Precursor;
GN   Name=Tm9sf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays an essential role in autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
CC       Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC       {ECO:0000305}.
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DR   EMBL; BC081891; AAH81891.1; -; mRNA.
DR   RefSeq; NP_001012155.1; NM_001012155.1.
DR   AlphaFoldDB; Q66HF2; -.
DR   STRING; 10116.ENSRNOP00000026734; -.
DR   GlyGen; Q66HF2; 3 sites.
DR   jPOST; Q66HF2; -.
DR   PaxDb; Q66HF2; -.
DR   PeptideAtlas; Q66HF2; -.
DR   Ensembl; ENSRNOT00000026734; ENSRNOP00000026734; ENSRNOG00000019710.
DR   GeneID; 361043; -.
DR   KEGG; rno:361043; -.
DR   UCSC; RGD:1307085; rat.
DR   CTD; 10548; -.
DR   RGD; 1307085; Tm9sf1.
DR   eggNOG; KOG1277; Eukaryota.
DR   GeneTree; ENSGT00940000158667; -.
DR   HOGENOM; CLU_010714_0_2_1; -.
DR   InParanoid; Q66HF2; -.
DR   OMA; EWNGDRI; -.
DR   OrthoDB; 641127at2759; -.
DR   PhylomeDB; Q66HF2; -.
DR   PRO; PR:Q66HF2; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000019710; Expressed in liver and 20 other tissues.
DR   Genevisible; Q66HF2; RN.
DR   GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR   InterPro; IPR004240; EMP70.
DR   PANTHER; PTHR10766; PTHR10766; 1.
DR   Pfam; PF02990; EMP70; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasmic vesicle; Glycoprotein; Lysosome; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..589
FT                   /note="Transmembrane 9 superfamily member 1"
FT                   /id="PRO_0000034364"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        401
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        542
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   589 AA;  66918 MW;  C429C098C911E3CB CRC64;
     MTVLGHPRSW SCHCLPVLIL LLGIGHGPRV EGVTHYKPGD PVILYVNKVG PYHNPQETYH
     YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN VEKRILCHMQ LSSAQVEQLR
     QAIEELYYFE FVVDDLPIRG FVGYMEESGF LPHSHKIGLW THLDFHLEFH GDRIIFANVS
     VRDVKPHSLD GLRSDELLGL THTYSVRWSE TSVEHRSDRR RADDGGFFPR TLEIHWLSII
     NSMVLVFLLV GFVAVILMRV LRNDLARYNL DEETSSGGSS DDFDQGDNGW KIIHTDVFRF
     PPCRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA LTCCISGYVS
     SHFYRQIGGE RWVWNIILTT SLFSVPFFLT WSVVNSVHWA NGSTQALPVT TILLLLTVWL
     LVGFPLTVIG GIFGKNNASP FDAPCRTKNI AREIPPQPCA ISVELYYIFA TVWGREQYTL
     YGILFFVFAI LLSVGACISI ALTYFQLSGE DYRWWWRSVL SVGSTGLFIF LYSVFYYARR
     SNMSGAVQTV EFFGYSLLTG YVFFLMLGTI SFFSSLKFIR YIYVNLKMD