TM9S2_MOUSE
ID TM9S2_MOUSE Reviewed; 662 AA.
AC P58021;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane 9 superfamily member 2;
DE Flags: Precursor;
GN Name=Tm9sf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: In the intracellular compartments, may function as a channel
CC or small molecule transporter. {ECO:0000250|UniProtKB:Q99805}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q99805};
CC Multi-pass membrane protein {ECO:0000255}. Golgi outpost
CC {ECO:0000250|UniProtKB:Q66HG5}. Cytoplasm, cytoskeleton, microtubule
CC organizing center {ECO:0000250|UniProtKB:Q66HG5}. Note=Localizes to the
CC postsynaptic Golgi apparatus region, also named Golgi outpost, which
CC shapes dendrite morphology by functioning as sites of acentrosomal
CC microtubule nucleation. {ECO:0000250|UniProtKB:Q66HG5}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000305}.
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DR EMBL; BC003862; AAH03862.1; -; mRNA.
DR CCDS; CCDS27345.1; -.
DR RefSeq; NP_542123.3; NM_080556.3.
DR AlphaFoldDB; P58021; -.
DR STRING; 10090.ENSMUSP00000026624; -.
DR iPTMnet; P58021; -.
DR PhosphoSitePlus; P58021; -.
DR SwissPalm; P58021; -.
DR EPD; P58021; -.
DR jPOST; P58021; -.
DR PaxDb; P58021; -.
DR PeptideAtlas; P58021; -.
DR PRIDE; P58021; -.
DR ProteomicsDB; 262833; -.
DR Antibodypedia; 970; 75 antibodies from 17 providers.
DR DNASU; 68059; -.
DR Ensembl; ENSMUST00000026624; ENSMUSP00000026624; ENSMUSG00000025544.
DR GeneID; 68059; -.
DR KEGG; mmu:68059; -.
DR UCSC; uc007vaw.1; mouse.
DR CTD; 9375; -.
DR MGI; MGI:1915309; Tm9sf2.
DR VEuPathDB; HostDB:ENSMUSG00000025544; -.
DR eggNOG; KOG1278; Eukaryota.
DR GeneTree; ENSGT00940000157563; -.
DR InParanoid; P58021; -.
DR OMA; TILITYH; -.
DR OrthoDB; 641127at2759; -.
DR PhylomeDB; P58021; -.
DR TreeFam; TF300394; -.
DR BioGRID-ORCS; 68059; 10 hits in 74 CRISPR screens.
DR ChiTaRS; Tm9sf2; mouse.
DR PRO; PR:P58021; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P58021; protein.
DR Bgee; ENSMUSG00000025544; Expressed in paneth cell and 266 other tissues.
DR ExpressionAtlas; P58021; baseline and differential.
DR Genevisible; P58021; MM.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0006672; P:ceramide metabolic process; ISO:MGI.
DR GO; GO:0006688; P:glycosphingolipid biosynthetic process; ISO:MGI.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR GO; GO:0010908; P:regulation of heparan sulfate proteoglycan biosynthetic process; ISO:MGI.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Endosome; Golgi apparatus; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..662
FT /note="Transmembrane 9 superfamily member 2"
FT /id="PRO_0000034366"
FT TOPO_DOM 29..299
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..397
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..436
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..465
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 487..521
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 543..553
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 575..590
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 612..630
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 652..662
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 662 AA; 75330 MW; 85F113A5D21733E7 CRC64;
MSSRPPASPP AQGSRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCAEE KSNECKADIE
LFVNRLDSVE SVLPYEYTAF DFCQASEGKR PSENLGQVLF GERIEPSPYK FTFNKKETCK
LVCTKTYNTE KAEDKQKLDF LKKSMLLNYQ HHWIVDNMPV TWCYEVEDSQ KFCNPGFPIG
CYITDKGHAK DACVISSEFH ERDTFYIFNH VDIKIYYHVV ETGSMGARLV AAKLEPKSFK
HTHIDKPDCS GPAMDISNKA SGEIKIAYTY SISFEEEKNI RWASRWDYIL ESMPHTHIQW
FSIMNSLVIV LFLSGMVAMI MLRTLHKDIA RYNQMDSTED AQEEFGWKLV HGDIFRPPRK
GMLLSVFLGS GTQILIMTFV TLFFACLGFL SPANRGALMT CAVVLWVLLG TPAGYVAARF
YKSFGGEKWK TNVLLTSFLC PGIVFADFFI MNLILWGEGS SAAIPFGTLV AILALWFCIS
VPLTFIGAYF GFKKNAIEHP VRTNQIPRQI PEQSFYTKPL PGIIMGGILP FGCIFIQLFF
ILNSIWSHQM YYMFGFLFLV FIILVITCSE ATILLCYFHL CAEDYHWQWR SFLTSGFTAV
YFLIYAIHYF FSKLQITGTA STILYFGYTM IMVLIFFLFT GTIGFFACFW FVTKIYSVVK
VD
