ID   TM9S2_PONAB             Reviewed;         663 AA.
AC   Q5R8Y6;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Transmembrane 9 superfamily member 2;
DE   Flags: Precursor;
GN   Name=TM9SF2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the intracellular compartments, may function as a channel
CC       or small molecule transporter. {ECO:0000250|UniProtKB:Q99805}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q99805};
CC       Multi-pass membrane protein {ECO:0000255}. Golgi outpost
CC       {ECO:0000250|UniProtKB:Q66HG5}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center {ECO:0000250|UniProtKB:Q66HG5}. Note=Localizes to the
CC       postsynaptic Golgi apparatus region, also named Golgi outpost, which
CC       shapes dendrite morphology by functioning as sites of acentrosomal
CC       microtubule nucleation. {ECO:0000250|UniProtKB:Q66HG5}.
CC   -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC       {ECO:0000305}.
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DR   EMBL; CR859611; CAH91774.1; -; mRNA.
DR   RefSeq; NP_001126027.1; NM_001132555.1.
DR   AlphaFoldDB; Q5R8Y6; -.
DR   STRING; 9601.ENSPPYP00000006235; -.
DR   Ensembl; ENSPPYT00000006481; ENSPPYP00000006235; ENSPPYG00000005468.
DR   GeneID; 100172975; -.
DR   KEGG; pon:100172975; -.
DR   CTD; 9375; -.
DR   eggNOG; KOG1278; Eukaryota.
DR   GeneTree; ENSGT00940000157563; -.
DR   HOGENOM; CLU_010714_4_1_1; -.
DR   InParanoid; Q5R8Y6; -.
DR   OMA; TILITYH; -.
DR   OrthoDB; 641127at2759; -.
DR   TreeFam; TF300394; -.
DR   Proteomes; UP000001595; Chromosome 13.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
DR   GO; GO:0006688; P:glycosphingolipid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010908; P:regulation of heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR004240; EMP70.
DR   PANTHER; PTHR10766; PTHR10766; 1.
DR   Pfam; PF02990; EMP70; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Endosome; Golgi apparatus; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..663
FT                   /note="Transmembrane 9 superfamily member 2"
FT                   /id="PRO_0000034367"
FT   TOPO_DOM        29..300
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        322..374
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        396..398
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        420..437
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        459..466
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        488..522
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        544..554
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        576..591
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        592..612
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        613..631
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        632..652
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        653..663
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   663 AA;  75817 MW;  26F4D2141E915EE0 CRC64;
     MSARLPVLSP PRWPRLLLLS LLLLGAVPGP RRSGGFYLPG LAPVNFCDEE KKSDECKAEI
     ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL FGERIEPSPY KFTFNKEETC
     KLVCTKTYHT EKAEDKQKLE FLKKSMLLNY QHHWIVDNMP VTWCYDVEDG QRFCNPGFPI
     GCYITDKGHA KDACVINSEF HERDTFYIFN HVDIKIYYHV VETGSMGARL VAAKLEPKSF
     KHTHIDKPDC SGPPMDISNK ASGEIKIAYT YSVSFEEDKK IRWASRWDYI LESMPHTHIQ
     WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL VHGDIFRPPR
     KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM TCAVVLWVLL GTPAGYVAAR
     FYKSFGGEKW KTNVLLTSFL CPGIVFADFF IMNLILWGEG SSAAIPFGTL VAILALWFCI
     SVPLTFIGAY FGFKKNAIEH PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF
     FILNSIWSHQ MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
     VYFLIYAVHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF WFVTKIYSVV
     KVD