TM9S3_MOUSE
ID TM9S3_MOUSE Reviewed; 587 AA.
AC Q9ET30;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transmembrane 9 superfamily member 3;
DE Flags: Precursor;
GN Name=Tm9sf3; Synonyms=Smbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Warner S.J., Lomax M.I.;
RT "Evolution of the TM9 super family of membrane spanning proteins.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-587.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-172.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-172.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH04799.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF269151; AAF98160.1; -; mRNA.
DR EMBL; BC004799; AAH04799.2; ALT_INIT; mRNA.
DR CCDS; CCDS29808.1; -.
DR RefSeq; NP_579930.1; NM_133352.2.
DR AlphaFoldDB; Q9ET30; -.
DR BioGRID; 223248; 9.
DR IntAct; Q9ET30; 1.
DR STRING; 10090.ENSMUSP00000025989; -.
DR GlyGen; Q9ET30; 2 sites.
DR iPTMnet; Q9ET30; -.
DR PhosphoSitePlus; Q9ET30; -.
DR SwissPalm; Q9ET30; -.
DR EPD; Q9ET30; -.
DR jPOST; Q9ET30; -.
DR MaxQB; Q9ET30; -.
DR PaxDb; Q9ET30; -.
DR PeptideAtlas; Q9ET30; -.
DR PRIDE; Q9ET30; -.
DR ProteomicsDB; 259234; -.
DR Antibodypedia; 50246; 89 antibodies from 20 providers.
DR DNASU; 107358; -.
DR Ensembl; ENSMUST00000237871; ENSMUSP00000158318; ENSMUSG00000025016.
DR GeneID; 107358; -.
DR KEGG; mmu:107358; -.
DR UCSC; uc008hls.1; mouse.
DR CTD; 56889; -.
DR MGI; MGI:1914262; Tm9sf3.
DR VEuPathDB; HostDB:ENSMUSG00000025016; -.
DR eggNOG; KOG1277; Eukaryota.
DR GeneTree; ENSGT00940000155493; -.
DR HOGENOM; CLU_010714_0_2_1; -.
DR InParanoid; Q9ET30; -.
DR OMA; APCRVNA; -.
DR OrthoDB; 641127at2759; -.
DR PhylomeDB; Q9ET30; -.
DR TreeFam; TF314271; -.
DR BioGRID-ORCS; 107358; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Tm9sf3; mouse.
DR PRO; PR:Q9ET30; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9ET30; protein.
DR Bgee; ENSMUSG00000025016; Expressed in seminal vesicle and 248 other tissues.
DR ExpressionAtlas; Q9ET30; baseline and differential.
DR Genevisible; Q9ET30; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..587
FT /note="Transmembrane 9 superfamily member 3"
FT /id="PRO_0000034370"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973,
FT ECO:0000269|PubMed:19656770"
FT CARBOHYD 417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 587 AA; 67545 MW; 22FD4F8588FEC2AE CRC64;
MRPLPGAPGV AAAAALLLLL LPRARSDEHE HTYQDKEEVV LWMNTVGPYH NRQETYKYFS
LPFCVGSKKS ISHYHETLGE ALQGVELEFS GLDIKFKDDV MPGTYCEIDL DKEKRDAFVY
AIKNHYWYQM YIDDLPIWGI VGEADENGED YYLWTYKKLE IGFNGNRIVD VNLTSEGKVK
LVPNTKIQMS YSVKWKKSDV KFEDRFDKYL DPSFFQHRIH WFSIFNSFMM VIFLVGLVSM
ILMRTLRKDY ARYSKEEEMD DMDRDLGDEY GWKQVHGDVF RPSSHPLIFS SLIGSGCQIF
AVSLIVIIVA MIEDLYTERG SMLSTAIFVY AATSPVNGYF GGSLYARQGG RRWIKQMFIG
AFLIPAMVCG TAFFINFIAI YYHASRAIPF GTMVAVCCIC FFVILPLNLV GTILGRNLSG
QPNFPCRVNA VPRPIPEKKW FMEPAVIVCL GGILPFGSIF IEMYFIFTSF WAYKIYYVYG
FMMLVLVILC IVTVCVTIVC TYFLLNAEDY RWQWTSFLSA ASTAIYVYMY SFYYYFFKTK
MYGLFQTSFY FGYMAVFSTA LGIMCGAIGY MGTSAFVRKI YTNVKID
