TM9S4_RAT
ID TM9S4_RAT Reviewed; 643 AA.
AC Q4KLL4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Transmembrane 9 superfamily member 4;
DE Flags: Precursor;
GN Name=Tm9sf4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Associates with proteins harboring glycine-rich transmembrane
CC domains and ensures their efficient localization to the cell surface.
CC {ECO:0000250|UniProtKB:Q92544}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q92544}.
CC Early endosome {ECO:0000250|UniProtKB:Q92544}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000305}.
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DR EMBL; BC099133; AAH99133.1; -; mRNA.
DR RefSeq; NP_001020820.1; NM_001025649.1.
DR AlphaFoldDB; Q4KLL4; -.
DR SMR; Q4KLL4; -.
DR IntAct; Q4KLL4; 1.
DR STRING; 10116.ENSRNOP00000062975; -.
DR SwissPalm; Q4KLL4; -.
DR jPOST; Q4KLL4; -.
DR PaxDb; Q4KLL4; -.
DR PRIDE; Q4KLL4; -.
DR Ensembl; ENSRNOT00000081370; ENSRNOP00000075230; ENSRNOG00000009406.
DR GeneID; 296279; -.
DR KEGG; rno:296279; -.
DR UCSC; RGD:1307768; rat.
DR CTD; 9777; -.
DR RGD; 1307768; Tm9sf4.
DR eggNOG; KOG1278; Eukaryota.
DR GeneTree; ENSGT00940000157198; -.
DR HOGENOM; CLU_010714_4_1_1; -.
DR InParanoid; Q4KLL4; -.
DR OMA; CYPKNGT; -.
DR OrthoDB; 641127at2759; -.
DR PhylomeDB; Q4KLL4; -.
DR TreeFam; TF354239; -.
DR PRO; PR:Q4KLL4; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000009406; Expressed in liver and 19 other tissues.
DR ExpressionAtlas; Q4KLL4; baseline and differential.
DR Genevisible; Q4KLL4; RN.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; ISO:RGD.
DR GO; GO:0006909; P:phagocytosis; ISO:RGD.
DR GO; GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; ISS:UniProtKB.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; ISO:RGD.
DR GO; GO:0001666; P:response to hypoxia; ISO:RGD.
DR GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; ISO:RGD.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 2: Evidence at transcript level;
KW Endosome; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..643
FT /note="Transmembrane 9 superfamily member 4"
FT /id="PRO_0000311812"
FT TOPO_DOM 24..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..377
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..417
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 439..450
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 472..502
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 524..536
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 558..571
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 593..599
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 621..643
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 313
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q92544"
SQ SEQUENCE 643 AA; 74675 MW; 4D087E0F468402F7 CRC64;
MAAAMIWWPR FLLLLCLTCK GSTFYVPGVA PINFHQNDPV EIKAVKLTSS RTQLPYEYYS
LPFCQPNKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC EVLCGQSNKP VILTVEQSRL
VAERITEEYY VHLIADNLPV ATRLELYSSN RDSDDKKKEK DVQFEHGYRL GFTDVNKIYL
HNHLSFILYY HREDTEEDQE HTYRVVRFEV IPQSIRLEDL KIDEKSSCTL PEGANSLPQE
IDPTKENQLY FTYSVHWEES DIKWASRWDT YLTMSDVQIH WFSIINSVVV VFFLSGILSM
IIIRTLRKDI ANYNKEDDIE DTMEESGWKL VHGDVFRPPQ YPMILSSLLG SGIQLFCMIL
IVIFVAMLGM LSPSSRGALM TTACFLFMFM GVFGGFSAGR LYRTLKGHRW KKGAFCTATL
YPGVVFGICF VLNCFIWGKH SSGAVPFPTM VALLCMWFGI SLPLVYLGYY FGFRKQPYDN
PVRTNQIPRQ IPEQRWYMNR FVGILMAGIL PFGAMFIELF FIFSAIWENQ FYYLFGFLFL
VFIILVVSCS QISIVMVYFQ LCAEDYRWWW RNFLVSGGSA FYVLVYAIFY FVNKLDIVEF
IPSLLYFGYT TLMVLSFWLL TGTIGFYAAY MFVRKIYAAV KID
