TMA16_HUMAN
ID TMA16_HUMAN Reviewed; 203 AA.
AC Q96EY4; Q0P6E4; Q0P6J1; Q9NUR7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Translation machinery-associated protein 16;
GN Name=TMA16; Synonyms=C4orf43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-65 AND THR-176.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-65 AND THR-176.
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [6]
RP ADP-RIBOSYLATION AT SER-9.
RX PubMed=28190768; DOI=10.1016/j.molcel.2017.01.003;
RA Bonfiglio J.J., Fontana P., Zhang Q., Colby T., Gibbs-Seymour I.,
RA Atanassov I., Bartlett E., Zaja R., Ahel I., Matic I.;
RT "Serine ADP-ribosylation depends on HPF1.";
RL Mol. Cell 0:0-0(2017).
RN [7] {ECO:0007744|PDB:6LSS, ECO:0007744|PDB:6LU8}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.13 ANGSTROMS), FUNCTION, INTERACTION
RP WITH PRE-60S RIBOSOMAL PARTICLES, AND SUBCELLULAR LOCATION.
RX PubMed=32669547; DOI=10.1038/s41467-020-17237-x;
RA Liang X., Zuo M.Q., Zhang Y., Li N., Ma C., Dong M.Q., Gao N.;
RT "Structural snapshots of human pre-60S ribosomal particles before and after
RT nuclear export.";
RL Nat. Commun. 11:3542-3542(2020).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit in
CC the nucleus. {ECO:0000269|PubMed:32669547}.
CC -!- SUBUNIT: Associates with pre-60S ribosomal particles.
CC {ECO:0000269|PubMed:32669547}.
CC -!- INTERACTION:
CC Q96EY4; Q96CW1: AP2M1; NbExp=3; IntAct=EBI-1045338, EBI-297683;
CC Q96EY4; Q8WTX7: CASTOR1; NbExp=3; IntAct=EBI-1045338, EBI-10276168;
CC Q96EY4; P42858: HTT; NbExp=3; IntAct=EBI-1045338, EBI-466029;
CC Q96EY4; O95198: KLHL2; NbExp=7; IntAct=EBI-1045338, EBI-746999;
CC Q96EY4; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-1045338, EBI-10172290;
CC Q96EY4; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-1045338, EBI-947459;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:32669547}.
CC -!- SIMILARITY: Belongs to the TMA16 family. {ECO:0000305}.
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DR EMBL; AK002046; BAA92053.1; -; mRNA.
DR EMBL; AC093788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC011842; AAH11842.1; -; mRNA.
DR CCDS; CCDS43278.1; -.
DR RefSeq; NP_060822.2; NM_018352.2.
DR PDB; 6LSS; EM; 3.23 A; R=1-203.
DR PDB; 6LU8; EM; 3.13 A; R=1-203.
DR PDBsum; 6LSS; -.
DR PDBsum; 6LU8; -.
DR AlphaFoldDB; Q96EY4; -.
DR SMR; Q96EY4; -.
DR BioGRID; 120600; 73.
DR IntAct; Q96EY4; 38.
DR MINT; Q96EY4; -.
DR STRING; 9606.ENSP00000351380; -.
DR GlyGen; Q96EY4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96EY4; -.
DR PhosphoSitePlus; Q96EY4; -.
DR BioMuta; TMA16; -.
DR DMDM; 190360168; -.
DR EPD; Q96EY4; -.
DR jPOST; Q96EY4; -.
DR MassIVE; Q96EY4; -.
DR MaxQB; Q96EY4; -.
DR PaxDb; Q96EY4; -.
DR PeptideAtlas; Q96EY4; -.
DR PRIDE; Q96EY4; -.
DR ProteomicsDB; 76468; -.
DR Antibodypedia; 28270; 101 antibodies from 14 providers.
DR DNASU; 55319; -.
DR Ensembl; ENST00000358572.10; ENSP00000351380.5; ENSG00000198498.10.
DR GeneID; 55319; -.
DR KEGG; hsa:55319; -.
DR MANE-Select; ENST00000358572.10; ENSP00000351380.5; NM_018352.3; NP_060822.2.
DR UCSC; uc003iqq.5; human.
DR CTD; 55319; -.
DR DisGeNET; 55319; -.
DR GeneCards; TMA16; -.
DR HGNC; HGNC:25638; TMA16.
DR HPA; ENSG00000198498; Low tissue specificity.
DR neXtProt; NX_Q96EY4; -.
DR OpenTargets; ENSG00000198498; -.
DR PharmGKB; PA162379923; -.
DR VEuPathDB; HostDB:ENSG00000198498; -.
DR eggNOG; ENOG502RXYZ; Eukaryota.
DR GeneTree; ENSGT00390000004179; -.
DR HOGENOM; CLU_105581_1_0_1; -.
DR InParanoid; Q96EY4; -.
DR OMA; SWFLGQI; -.
DR OrthoDB; 1541925at2759; -.
DR PhylomeDB; Q96EY4; -.
DR TreeFam; TF324892; -.
DR PathwayCommons; Q96EY4; -.
DR SignaLink; Q96EY4; -.
DR BioGRID-ORCS; 55319; 635 hits in 1048 CRISPR screens.
DR ChiTaRS; TMA16; human.
DR GenomeRNAi; 55319; -.
DR Pharos; Q96EY4; Tdark.
DR PRO; PR:Q96EY4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96EY4; protein.
DR Bgee; ENSG00000198498; Expressed in calcaneal tendon and 158 other tissues.
DR ExpressionAtlas; Q96EY4; baseline and differential.
DR Genevisible; Q96EY4; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR Gene3D; 1.20.1440.170; -; 1.
DR InterPro; IPR021346; Tma16.
DR InterPro; IPR038356; Tma16_sf.
DR PANTHER; PTHR13349; PTHR13349; 1.
DR Pfam; PF11176; Tma16; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ADP-ribosylation; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..203
FT /note="Translation machinery-associated protein 16"
FT /id="PRO_0000321559"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="ADP-ribosylserine"
FT /evidence="ECO:0000269|PubMed:28190768"
FT VARIANT 12
FT /note="R -> Q (in dbSNP:rs34907234)"
FT /id="VAR_054013"
FT VARIANT 65
FT /note="Q -> P (in dbSNP:rs2304802)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_039349"
FT VARIANT 176
FT /note="I -> T (in dbSNP:rs1561736)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_039350"
FT CONFLICT 62
FT /note="L -> P (in Ref. 1; BAA92053)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 203 AA; 23864 MW; 624EDA50DD76AC48 CRC64;
MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL VGEKLQWFQN
HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD RQGRRHCSRE TVIKQTMERE
RQQFEGYGLE IPDILNASNL KTFREWDFDL KKLPNIKMRK ICANDAIPKT CKRKTIITVD
QDLGELELND ESSDSDEEMT AVA
