TMA16_MOUSE
ID TMA16_MOUSE Reviewed; 221 AA.
AC Q9CR02; Q05DD8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Translation machinery-associated protein 16;
GN Name=Tma16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit in
CC the nucleus. {ECO:0000250|UniProtKB:Q96EY4}.
CC -!- SUBUNIT: Associates with pre-60S ribosomal particles.
CC {ECO:0000250|UniProtKB:Q96EY4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96EY4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CR02-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CR02-2; Sequence=VSP_031803;
CC -!- SIMILARITY: Belongs to the TMA16 family. {ECO:0000305}.
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DR EMBL; AK007637; BAB25153.1; -; mRNA.
DR EMBL; AK011532; BAB27681.1; -; mRNA.
DR EMBL; BC016246; AAH16246.1; -; mRNA.
DR EMBL; BC034844; AAH34844.1; -; mRNA.
DR CCDS; CCDS40353.1; -. [Q9CR02-1]
DR RefSeq; NP_079741.1; NM_025465.2. [Q9CR02-1]
DR RefSeq; XP_006509778.1; XM_006509715.3.
DR AlphaFoldDB; Q9CR02; -.
DR SMR; Q9CR02; -.
DR BioGRID; 211354; 3.
DR IntAct; Q9CR02; 1.
DR MINT; Q9CR02; -.
DR STRING; 10090.ENSMUSP00000026681; -.
DR iPTMnet; Q9CR02; -.
DR PhosphoSitePlus; Q9CR02; -.
DR EPD; Q9CR02; -.
DR MaxQB; Q9CR02; -.
DR PaxDb; Q9CR02; -.
DR PeptideAtlas; Q9CR02; -.
DR PRIDE; Q9CR02; -.
DR ProteomicsDB; 259418; -. [Q9CR02-1]
DR ProteomicsDB; 259419; -. [Q9CR02-2]
DR Antibodypedia; 28270; 101 antibodies from 14 providers.
DR DNASU; 66282; -.
DR Ensembl; ENSMUST00000026681; ENSMUSP00000026681; ENSMUSG00000025591. [Q9CR02-1]
DR GeneID; 66282; -.
DR KEGG; mmu:66282; -.
DR UCSC; uc009lvo.2; mouse. [Q9CR02-1]
DR CTD; 55319; -.
DR MGI; MGI:1913532; Tma16.
DR VEuPathDB; HostDB:ENSMUSG00000025591; -.
DR eggNOG; ENOG502RXYZ; Eukaryota.
DR GeneTree; ENSGT00390000004179; -.
DR HOGENOM; CLU_105581_1_0_1; -.
DR InParanoid; Q9CR02; -.
DR OMA; LQWFHSH; -.
DR OrthoDB; 1541925at2759; -.
DR PhylomeDB; Q9CR02; -.
DR TreeFam; TF324892; -.
DR BioGRID-ORCS; 66282; 25 hits in 73 CRISPR screens.
DR ChiTaRS; Tma16; mouse.
DR PRO; PR:Q9CR02; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CR02; protein.
DR Bgee; ENSMUSG00000025591; Expressed in morula and 167 other tissues.
DR ExpressionAtlas; Q9CR02; baseline and differential.
DR Genevisible; Q9CR02; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR Gene3D; 1.20.1440.170; -; 1.
DR InterPro; IPR021346; Tma16.
DR InterPro; IPR038356; Tma16_sf.
DR PANTHER; PTHR13349; PTHR13349; 1.
DR Pfam; PF11176; Tma16; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..221
FT /note="Translation machinery-associated protein 16"
FT /id="PRO_0000321560"
FT REGION 180..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031803"
SQ SEQUENCE 221 AA; 25782 MW; 3A8AEF65270E5853 CRC64;
MPKGLKGKMV GREKKVIHPY SRKAAQITRE SHKQDKKERL KTEKALRLNL IGDKLQWFHS
HLDMKKTRYS KKDACELVER YLDRFSSELE QIELQNSIKD RQGRRHHSRE AVIKQTLERE
RQQYEGYGFE IPDILDSNTL QTFREWDFDL KKLPNIKMRK LCADDAVPKK RKQKNILNIE
KDLGELELSG PTGATTDGKL EPASESSDTD EEMTPVPVSP H
