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TMA20_YEAST
ID   TMA20_YEAST             Reviewed;         181 AA.
AC   P89886; D3DLQ4;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Translation machinery-associated protein 20;
GN   Name=TMA20; OrderedLocusNames=YER007C-A;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DOMAIN.
RX   PubMed=10093218; DOI=10.1007/pl00006472;
RA   Aravind L., Koonin E.V.;
RT   "Novel predicted RNA-binding domains associated with the translation
RT   machinery.";
RL   J. Mol. Evol. 48:291-302(1999).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   ASSOCIATION WITH RIBOSOMAL COMPLEXES, INTERACTION WITH TMA22, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=16702403; DOI=10.1101/gad.1422006;
RA   Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.;
RT   "Systematic identification and functional screens of uncharacterized
RT   proteins associated with eukaryotic ribosomal complexes.";
RL   Genes Dev. 20:1294-1307(2006).
RN   [7]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: Involved in translation.
CC   -!- SUBUNIT: Interacts with TMA22. Associates with ribosomal complexes.
CC       {ECO:0000269|PubMed:16702403}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 4220 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the TMA20 family. {ECO:0000305}.
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DR   EMBL; U18778; AAB64566.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07658.1; -; Genomic_DNA.
DR   PIR; S53543; S53543.
DR   RefSeq; NP_010923.3; NM_001180857.3.
DR   AlphaFoldDB; P89886; -.
DR   SMR; P89886; -.
DR   BioGRID; 36738; 54.
DR   DIP; DIP-1841N; -.
DR   IntAct; P89886; 8.
DR   MINT; P89886; -.
DR   STRING; 4932.YER007C-A; -.
DR   iPTMnet; P89886; -.
DR   MaxQB; P89886; -.
DR   PaxDb; P89886; -.
DR   PRIDE; P89886; -.
DR   EnsemblFungi; YER007C-A_mRNA; YER007C-A; YER007C-A.
DR   GeneID; 856725; -.
DR   KEGG; sce:YER007C-A; -.
DR   SGD; S000002957; TMA20.
DR   VEuPathDB; FungiDB:YER007C-A; -.
DR   eggNOG; KOG2523; Eukaryota.
DR   GeneTree; ENSGT00550000074964; -.
DR   HOGENOM; CLU_090468_0_1_1; -.
DR   InParanoid; P89886; -.
DR   OMA; HDHIEIL; -.
DR   BioCyc; YEAST:G3O-30353-MON; -.
DR   PRO; PR:P89886; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P89886; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005829; C:cytosol; IDA:SGD.
DR   GO; GO:0003723; F:RNA binding; ISS:SGD.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; IMP:SGD.
DR   InterPro; IPR016437; MCT-1/Tma20.
DR   InterPro; IPR041366; Pre-PUA.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   PANTHER; PTHR22798; PTHR22798; 1.
DR   Pfam; PF17832; Pre-PUA; 1.
DR   Pfam; PF01472; PUA; 1.
DR   PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..181
FT                   /note="Translation machinery-associated protein 20"
FT                   /id="PRO_0000245367"
FT   DOMAIN          90..172
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0007744|PubMed:22814378"
SQ   SEQUENCE   181 AA;  20278 MW;  6BEAF43C6278B432 CRC64;
     MFKKFTREDV HSRSKVKSSI QRTLKAKLVK QYPKIEDVID ELIPKKSQIE LIKCEDKIQL
     YSVDGEVLFF QKFDELIPSL KLVHKFPEAY PTVQVDRGAI KFVLSGANIM CPGLTSAGAD
     LPPAPGYEKG TIVVINAENK ENALAIGELM MGTEEIKSVN KGHSIELIHH LGDPLWNFSV
     E
 
 
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