ID   TMA23_YEAST             Reviewed;         211 AA.
AC   Q03525; D6W095; Q7Z870;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Protein TMA23;
DE   AltName: Full=23 kDa translation machinery-associated protein;
GN   Name=TMA23; OrderedLocusNames=YMR269W; ORFNames=YM8156.11, YMR268W-A;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-109, AND IDENTIFICATION OF
RP   FRAMESHIFT.
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA   Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA   Gates K., Gaffney T.D., Philippsen P.;
RT   "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT   comparison to the genome of a related fungus: Ashbya gossypii.";
RL   Genome Biol. 4:R45.1-R45.13(2003).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   ASSOCIATION WITH RIBOSOMAL COMPLEXES, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=16702403; DOI=10.1101/gad.1422006;
RA   Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.;
RT   "Systematic identification and functional screens of uncharacterized
RT   proteins associated with eukaryotic ribosomal complexes.";
RL   Genes Dev. 20:1294-1307(2006).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
RX   PubMed=17425675; DOI=10.1111/j.1567-1364.2007.00230.x;
RA   Buchhaupt M., Koetter P., Entian K.-D.;
RT   "Mutations in the nucleolar proteins Tma23 and Nop6 suppress the
RT   malfunction of the Nep1 protein.";
RL   FEMS Yeast Res. 7:771-781(2007).
CC   -!- FUNCTION: Trans-acting factors of the ribosome biogenesis process.
CC       {ECO:0000269|PubMed:17425675}.
CC   -!- SUBUNIT: Forms homooligomers. Associates with ribosomal complexes.
CC       {ECO:0000269|PubMed:17425675}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14562095,
CC       ECO:0000269|PubMed:17425675}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA89252.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; Z49260; CAA89252.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AY227896; AAQ17205.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10169.1; -; Genomic_DNA.
DR   PIR; S54481; S54481.
DR   RefSeq; NP_013996.2; NM_001182776.1.
DR   AlphaFoldDB; Q03525; -.
DR   BioGRID; 35447; 316.
DR   DIP; DIP-1965N; -.
DR   IntAct; Q03525; 11.
DR   MINT; Q03525; -.
DR   STRING; 4932.YMR269W; -.
DR   MaxQB; Q03525; -.
DR   PaxDb; Q03525; -.
DR   PRIDE; Q03525; -.
DR   EnsemblFungi; YMR269W_mRNA; YMR269W; YMR269W.
DR   GeneID; 855311; -.
DR   KEGG; sce:YMR269W; -.
DR   SGD; S000004882; TMA23.
DR   VEuPathDB; FungiDB:YMR269W; -.
DR   eggNOG; KOG2809; Eukaryota.
DR   HOGENOM; CLU_082196_1_1_1; -.
DR   InParanoid; Q03525; -.
DR   OMA; DHTNQWW; -.
DR   BioCyc; YEAST:G3O-32942-MON; -.
DR   PRO; PR:Q03525; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03525; protein.
DR   GO; GO:0005730; C:nucleolus; IDA:SGD.
DR   GO; GO:0090069; P:regulation of ribosome biogenesis; IBA:GO_Central.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IGI:SGD.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..211
FT                   /note="Protein TMA23"
FT                   /id="PRO_0000203349"
FT   REGION          115..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..173
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   211 AA;  23949 MW;  F3B91B618ADF778B CRC64;
     MDSKEYLISY GWKEGEAFRE GGLKRPILVK HKRDKKGLGN APGGNDGEAW WERLFDGHLK
     NLDVSTDSNN GSIKFTQNEA VATAVSKSSS PLYRWFVKGE GLKGTITNLG KKEEASFVVS
     SASSSKGKKR RRRDEDDNKV KRKKLKKDKK TSNDSESKKK KKKKSKKESK KGKKSKHSSD
     EGDKSKHKKS KKSKKHKKEE SSARRDRKEH I