TMA7_HUMAN
ID TMA7_HUMAN Reviewed; 64 AA.
AC Q9Y2S6; Q9P052;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Translation machinery-associated protein 7;
DE AltName: Full=Coiled-coil domain-containing protein 72;
GN Name=TMA7; Synonyms=CCDC72; ORFNames=HSPC016, HSPC330;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair follicle;
RA Wang J.W., Song Z.Q., Hao F.;
RT "Analysis of dermal-papillae-cell-specific gene: HSPC016 and its
RT subtypes.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-64.
RC TISSUE=Umbilical cord blood;
RA Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L.,
RA Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
RT "Human partial CDS from CD34+ stem cells.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY.
RC TISSUE=Hair follicle;
RX PubMed=16096800; DOI=10.1007/s00403-005-0583-7;
RA Zhiqiang S., Jiwen W., Fei H., Weibin Y., Feng Z., Xichuan Y., Chunlan L.;
RT "Identification of differentially expressed genes HSPC016 in dermal papilla
RT cells with aggregative behavior.";
RL Arch. Dermatol. Res. 297:114-120(2005).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP ADP-RIBOSYLATION AT SER-61.
RX PubMed=28190768; DOI=10.1016/j.molcel.2017.01.003;
RA Bonfiglio J.J., Fontana P., Zhang Q., Colby T., Gibbs-Seymour I.,
RA Atanassov I., Bartlett E., Zaja R., Ahel I., Matic I.;
RT "Serine ADP-ribosylation depends on HPF1.";
RL Mol. Cell 0:0-0(2017).
CC -!- TISSUE SPECIFICITY: Expressed in dermal papilla cells with aggregative
CC behavior. {ECO:0000269|PubMed:16096800}.
CC -!- SIMILARITY: Belongs to the TMA7 family. {ECO:0000305}.
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DR EMBL; AF077202; AAD26997.1; -; mRNA.
DR EMBL; AY508979; AAR87665.1; -; mRNA.
DR EMBL; AY794023; AAV40981.1; -; mRNA.
DR EMBL; BC080531; AAH80531.1; -; mRNA.
DR EMBL; AF161448; AAF29008.1; -; mRNA.
DR CCDS; CCDS46823.1; -.
DR RefSeq; NP_057017.1; NM_015933.5.
DR AlphaFoldDB; Q9Y2S6; -.
DR BioGRID; 119505; 30.
DR IntAct; Q9Y2S6; 16.
DR MINT; Q9Y2S6; -.
DR STRING; 9606.ENSP00000397843; -.
DR iPTMnet; Q9Y2S6; -.
DR MetOSite; Q9Y2S6; -.
DR PhosphoSitePlus; Q9Y2S6; -.
DR BioMuta; TMA7; -.
DR EPD; Q9Y2S6; -.
DR jPOST; Q9Y2S6; -.
DR MassIVE; Q9Y2S6; -.
DR MaxQB; Q9Y2S6; -.
DR PaxDb; Q9Y2S6; -.
DR PeptideAtlas; Q9Y2S6; -.
DR PRIDE; Q9Y2S6; -.
DR ProteomicsDB; 85886; -.
DR TopDownProteomics; Q9Y2S6; -.
DR Antibodypedia; 45855; 24 antibodies from 13 providers.
DR DNASU; 51372; -.
DR Ensembl; ENST00000438607.2; ENSP00000397843.2; ENSG00000232112.3.
DR GeneID; 51372; -.
DR KEGG; hsa:51372; -.
DR MANE-Select; ENST00000438607.2; ENSP00000397843.2; NM_015933.6; NP_057017.1.
DR UCSC; uc003cte.2; human.
DR CTD; 51372; -.
DR GeneCards; TMA7; -.
DR HGNC; HGNC:26932; TMA7.
DR HPA; ENSG00000232112; Low tissue specificity.
DR MIM; 615808; gene.
DR neXtProt; NX_Q9Y2S6; -.
DR OpenTargets; ENSG00000232112; -.
DR PharmGKB; PA143485423; -.
DR VEuPathDB; HostDB:ENSG00000232112; -.
DR eggNOG; KOG4766; Eukaryota.
DR GeneTree; ENSGT00390000003710; -.
DR HOGENOM; CLU_184661_1_1_1; -.
DR InParanoid; Q9Y2S6; -.
DR OMA; KKGPMNT; -.
DR TreeFam; TF300250; -.
DR PathwayCommons; Q9Y2S6; -.
DR SignaLink; Q9Y2S6; -.
DR BioGRID-ORCS; 51372; 240 hits in 1069 CRISPR screens.
DR ChiTaRS; TMA7; human.
DR GenomeRNAi; 51372; -.
DR Pharos; Q9Y2S6; Tdark.
DR PRO; PR:Q9Y2S6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9Y2S6; protein.
DR Bgee; ENSG00000232112; Expressed in granulocyte and 98 other tissues.
DR Genevisible; Q9Y2S6; HS.
DR InterPro; IPR015157; TMA7.
DR PANTHER; PTHR28632; PTHR28632; 1.
DR Pfam; PF09072; TMA7; 1.
PE 1: Evidence at protein level;
KW ADP-ribosylation; Coiled coil; Reference proteome.
FT CHAIN 1..64
FT /note="Translation machinery-associated protein 7"
FT /id="PRO_0000235681"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 21..50
FT /evidence="ECO:0000255"
FT COMPBIAS 16..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="ADP-ribosylserine"
FT /evidence="ECO:0000269|PubMed:28190768"
SQ SEQUENCE 64 AA; 7066 MW; E79BA054EC176B74 CRC64;
MSGREGGKKK PLKQPKKQAK EMDEEDKAFK QKQKEEQKKL EELKAKAAGK GPLATGGIKK
SGKK
