ID   TMBI4_CAEEL             Reviewed;         276 AA.
AC   Q11080; Q11079;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2003, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Transmembrane BAX inhibitor motif-containing protein 4;
GN   Name=tmbi-4; ORFNames=B0563.4/B0563.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000305}.
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DR   EMBL; FO080238; CCD62251.1; -; Genomic_DNA.
DR   PIR; T15358; T15358.
DR   PIR; T15360; T15360.
DR   RefSeq; NP_509543.2; NM_077142.5.
DR   AlphaFoldDB; Q11080; -.
DR   SMR; Q11080; -.
DR   BioGRID; 46068; 1.
DR   IntAct; Q11080; 1.
DR   STRING; 6239.B0563.4; -.
DR   EPD; Q11080; -.
DR   PaxDb; Q11080; -.
DR   EnsemblMetazoa; B0563.4.1; B0563.4.1; WBGene00006479.
DR   GeneID; 181150; -.
DR   KEGG; cel:CELE_B0563.4; -.
DR   CTD; 181150; -.
DR   WormBase; B0563.4; CE30843; WBGene00006479; tmbi-4.
DR   eggNOG; KOG2322; Eukaryota.
DR   GeneTree; ENSGT01050000244940; -.
DR   HOGENOM; CLU_058671_0_0_1; -.
DR   InParanoid; Q11080; -.
DR   OMA; YILYTHA; -.
DR   OrthoDB; 1290306at2759; -.
DR   PhylomeDB; Q11080; -.
DR   PRO; PR:Q11080; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006479; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..276
FT                   /note="Transmembrane BAX inhibitor motif-containing protein
FT                   4"
FT                   /id="PRO_0000179118"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   276 AA;  30410 MW;  818B7BE773BE5019 CRC64;
     MATINSHLRE PERVNLLSDH DDSDDDEVHV KRNPQMWPMS MASSAHAEAG IVDADGILPG
     CVGKANRMIR IAFLRKVLGI VGFQLLFTIG ICAAIYNIPN SNQLLQKHAW IVFPNLLGSI
     ALIIALHVYA REVPLNYVLL AAFTAVQAVT MGCVVTLFEA KVVLEAAVIT GLVVASLFAY
     TLQNKRDFSV GYASMGSLLC VLLWAGIFQM FFMSPAVNFV INVFGAGLFC VLLVIDLDMI
     MYRFSPEDYI CACVSLYMDI LNLFIRILQI VAEANK