TMBL2_PYRFU
ID TMBL2_PYRFU Reviewed; 264 AA.
AC Q8U3H1;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Putative HTH-type transcriptional regulator TrmBL2;
GN Name=trmBL2; OrderedLocusNames=PF0496;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2]
RP FUNCTION, DNA-BINDING, DOMAIN, AND GENE NAME.
RX PubMed=17587231; DOI=10.1111/j.1365-2958.2007.05780.x;
RA Lee S.J., Surma M., Seitz S., Hausner W., Thomm M., Boos W.;
RT "Characterization of the TrmB-like protein, PF0124, a TGM-recognizing
RT global transcriptional regulator of the hyperthermophilic archaeon
RT Pyrococcus furiosus.";
RL Mol. Microbiol. 65:305-318(2007).
CC -!- FUNCTION: Binds to the maltodextrin transport gene cluster (mdxE
CC operon) promoter and to some other TGM (Thermococcales-Glycolytic-
CC Motif) sequences, but not exclusively. {ECO:0000269|PubMed:17587231}.
CC -!- DOMAIN: Lacks the C-terminal sugar-binding domain.
CC {ECO:0000269|PubMed:17587231}.
CC -!- SIMILARITY: Belongs to the transcriptional regulator TrmB family.
CC {ECO:0000305}.
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DR EMBL; AE009950; AAL80620.1; -; Genomic_DNA.
DR RefSeq; WP_011011613.1; NZ_CP023154.1.
DR PDB; 5BOX; X-ray; 2.50 A; A/B/C/D=2-264.
DR PDB; 5BPD; X-ray; 2.40 A; A/B/C/D=1-264.
DR PDB; 5BPI; X-ray; 3.20 A; A/B/C/D=2-264.
DR PDB; 5BQT; X-ray; 3.00 A; A/B/C/D=2-263.
DR PDBsum; 5BOX; -.
DR PDBsum; 5BPD; -.
DR PDBsum; 5BPI; -.
DR PDBsum; 5BQT; -.
DR AlphaFoldDB; Q8U3H1; -.
DR SMR; Q8U3H1; -.
DR IntAct; Q8U3H1; 1.
DR STRING; 186497.PF0496; -.
DR PRIDE; Q8U3H1; -.
DR EnsemblBacteria; AAL80620; AAL80620; PF0496.
DR GeneID; 41712298; -.
DR KEGG; pfu:PF0496; -.
DR PATRIC; fig|186497.12.peg.519; -.
DR eggNOG; arCOG02037; Archaea.
DR HOGENOM; CLU_072493_0_2_2; -.
DR OMA; CGYTDNP; -.
DR OrthoDB; 72347at2157; -.
DR PhylomeDB; Q8U3H1; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR021586; Tscrpt_reg_TrmB_C.
DR InterPro; IPR002831; Tscrpt_reg_TrmB_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF11495; Regulator_TrmB; 1.
DR Pfam; PF01978; TrmB; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..264
FT /note="Putative HTH-type transcriptional regulator TrmBL2"
FT /id="PRO_0000428841"
FT DNA_BIND 33..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
FT HELIX 3..13
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 18..30
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 35..40
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 46..48
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 49..58
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 71..74
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 77..110
FT /evidence="ECO:0007829|PDB:5BPD"
FT TURN 111..113
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 125..129
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 132..145
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 148..156
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 158..161
FT /evidence="ECO:0007829|PDB:5BOX"
FT HELIX 163..171
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 175..181
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 182..187
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 189..192
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 193..198
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 201..208
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 214..217
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 220..224
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 228..232
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 238..242
FT /evidence="ECO:0007829|PDB:5BPD"
FT HELIX 244..258
FT /evidence="ECO:0007829|PDB:5BPD"
FT STRAND 261..263
FT /evidence="ECO:0007829|PDB:5BPD"
SQ SEQUENCE 264 AA; 30607 MW; B08D78D05CF1A254 CRC64;
MSKDRMVELL QEHFELNLYE ARAYVALVAF GVLTPAELAS VSEVPAPRTY DVLRSLEKKG
FAMTQPGKTN KYRPVHPANV LEKFIQDWQE RVKEELEAKK KAKEELLELM APLIETEVPK
YGVERVWVVR GIKNSTLKTK EMLEEAQNEI LLADDGFIAV NLEDDIIKAV DRGVKTKILL
TKNLLPRLKA SKIIDYAKEG KLELRALDKF DLPMLICDEE VFFALEDLAA RYFNYETQVW
IKDHRVVALF KEKFNEYWEK AEKV
