TMC1_CAEEL
ID TMC1_CAEEL Reviewed; 1285 AA.
AC D3KZG3; G4S885;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Transmembrane channel-like protein 1;
GN Name=tmc-1; ORFNames=T13G4.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=23364694; DOI=10.1038/nature11845;
RA Chatzigeorgiou M., Bang S., Hwang S.W., Schafer W.R.;
RT "tmc-1 encodes a sodium-sensitive channel required for salt chemosensation
RT in C. elegans.";
RL Nature 494:95-99(2013).
CC -!- FUNCTION: Sodium-sensor ion channel that acts specifically in salt
CC taste chemosensation. Required for salt-evoked neuronal activity and
CC behavioral avoidance of high concentrations of NaCl.
CC {ECO:0000269|PubMed:23364694}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23364694};
CC Multi-pass membrane protein {ECO:0000269|PubMed:23364694}.
CC -!- TISSUE SPECIFICITY: Expressed in the ASH polymodal avoidance neurons.
CC Also expressed in other sensory neurons, including the ADF, ASE, ADL,
CC AQR, PQR, URX and PHA cells. {ECO:0000269|PubMed:23364694}.
CC -!- DISRUPTION PHENOTYPE: No apparent defect in nose touch avoidance but
CC mutants show strong defects in the avoidance of NaCl concentrations
CC above 100 mM. Responses to other soluble repellents as well as to
CC hyperosmolarity are indistinguishable from wild-type animals.
CC {ECO:0000269|PubMed:23364694}.
CC -!- SIMILARITY: Belongs to the TMC family. {ECO:0000305}.
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DR EMBL; FO080889; CCD67541.1; -; Genomic_DNA.
DR EMBL; FO080360; CCD67541.1; JOINED; Genomic_DNA.
DR RefSeq; NP_508221.3; NM_075820.5.
DR AlphaFoldDB; D3KZG3; -.
DR STRING; 6239.T13G4.3; -.
DR TCDB; 1.A.17.4.7; the calcium-dependent chloride channel (ca-clc) family.
DR EPD; D3KZG3; -.
DR PaxDb; D3KZG3; -.
DR EnsemblMetazoa; T13G4.3.1; T13G4.3.1; WBGene00020490.
DR EnsemblMetazoa; T13G4.3.2; T13G4.3.2; WBGene00020490.
DR GeneID; 188483; -.
DR KEGG; cel:CELE_T13G4.3; -.
DR CTD; 188483; -.
DR WormBase; T13G4.3; CE37147; WBGene00020490; tmc-1.
DR eggNOG; ENOG502QQGX; Eukaryota.
DR GeneTree; ENSGT01050000244942; -.
DR HOGENOM; CLU_278527_0_0_1; -.
DR InParanoid; D3KZG3; -.
DR OMA; RYLYQES; -.
DR OrthoDB; 124678at2759; -.
DR PhylomeDB; D3KZG3; -.
DR PRO; PR:D3KZG3; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00020490; Expressed in larva and 3 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR GO; GO:0005216; F:ion channel activity; IDA:UniProtKB.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR GO; GO:0005272; F:sodium channel activity; IMP:CACAO.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IMP:UniProtKB.
DR GO; GO:0034220; P:ion transmembrane transport; IDA:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IMP:UniProtKB.
DR InterPro; IPR038900; TMC.
DR InterPro; IPR012496; TMC_dom.
DR PANTHER; PTHR23302; PTHR23302; 1.
DR Pfam; PF07810; TMC; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1285
FT /note="Transmembrane channel-like protein 1"
FT /id="PRO_0000421989"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 739..759
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 787..807
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 852..872
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1285 AA; 147129 MW; BC5A3332464D6D36 CRC64;
MQEAARRASL RKEHTPTNEK FGDLSKQDSL GERASSKLTL DDELYDILYA FGETDAFINK
GDKQRETDED GNPLTRQALL ERIRQKKEVI GKLRCQAWSM TRKRRTLKLA QKYLEQHESK
VSRSHLYMEE MRKRARLMKR SFSNFKTYLI PWESKIKRIE SHFGSVVSSY FTFLRWIVFV
NIMITLIALV FVVLPETLAD SVANEGRFNR TKTRKQIPAN ERVHADELAV VWHYDGYLRY
SPLFYGYYSD DPFLGNKIKY ALPLAYFMVT LTIFAYSFFA ILRKMAANAR MSKLSGSKAE
QYIFNWKLFT GWDYTIGNSE TASNTVMAVV IKLRESIADI KKDAHGKFRL LQFSLRVFAN
IIICAMLGFS IYCIIFAVQK SQVQDDGNLF TKNQVPSVVS TITHVFPMIF DLIGKMENYH
PRTALRAHLG RVLILYTVNY ITLIFALFEK MTALRDRVNS TSTSSSHRTK RQQGGWNPNM
QRPPPYASRA EVRQMSDFLA ANTRRFQTVS QRTTRSVTTP FTVAPQFGPF NVNNPNAVFH
NGTHSTSFES QILGPKALPI FTPPPRKYPG FTPGNVGQQF GGPDFPRNQV YTKSTPLPRV
RTKPPWVYTT THPPLVQNRA MTTTMSKSAK KGNSKNLDDD ILLSNETIQM SEAALRRNHD
GHNNDICWET IIGQEIVKLV TMDLIFTILS ILVIDLFRGL WIKYCSSWWC WDIETTFPEY
GEFKVAENVL HIINNQGMIW LGLFFAPLLP AINNIKLIIL MYIRGWAVMT CNVPAREIFR
ASRSSNFYLG ILLIWLLLCT LPVGFVIASM SPSRSCGPFA RYQHFYTVVT REIEKRVDQT
VLSYIRHIAS PGVVIPIILF LILIIYFLFS LVRGLREANT DLQAQLVHER TEEKKKIFEL
AGGKKNKFEK DRDKKRSNDY IPLIEQRRRE PWRQYHEMEA DHALASDSSE ESDINEDEDD
ERQPLTAYPL RAIETPPETL QVTAFHPSLG SLIENREMED EESASGDQLP MIHKSVSFQG
PSHMQMRQSI STESCSQISR SAIQVATPEE IRALLRPYLE AKYGIPYQHG IKSFPIDVHT
PPNNTPSRRS SKYNSFVSLY EHTRDDHKNF VASTIKETDE DPGKSDKKQT SSKDVAPDFM
PWPSADEARA LREKMKSKTP LMLTKTTVEE KPKGGKSSES EFRPPVPIHR KYNIQTTEEE
NEEEETDSAP ESSKKRFRIS VSPTKTIAPA SASRAQHKIV SQASSSSSIP HGRQPDPNKK
ASLVLPPLRA PRVQFDEDDS PRQID
