TMC3_MOUSE
ID TMC3_MOUSE Reviewed; 1130 AA.
AC Q7TQ69; Q7TN63;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Transmembrane channel-like protein 3;
GN Name=Tmc3 {ECO:0000312|EMBL:AAP78772.1, ECO:0000312|MGI:MGI:2669033};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAP78772.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP78772.1};
RX PubMed=12812529; DOI=10.1186/1471-2164-4-24;
RA Keresztes G., Mutai H., Heller S.;
RT "TMC and EVER genes belong to a larger novel family, the TMC gene family
RT encoding transmembrane proteins.";
RL BMC Genomics 4:24-24(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAP69869.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12906855; DOI=10.1016/s0888-7543(03)00154-x;
RA Kurima K., Yang Y., Sorber K., Griffith A.J.;
RT "Characterization of the transmembrane channel-like (TMC) gene family:
RT functional clues from hearing loss and epidermodysplasia verruciformis.";
RL Genomics 82:300-308(2003).
CC -!- FUNCTION: Probable ion channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:12812529};
CC IsoId=Q7TQ69-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12906855};
CC IsoId=Q7TQ69-2; Sequence=VSP_052203, VSP_052204;
CC -!- TISSUE SPECIFICITY: Detected in most neuronal organs and also in some
CC non-neuronal tissues. {ECO:0000269|PubMed:12812529}.
CC -!- SIMILARITY: Belongs to the TMC family. {ECO:0000255}.
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DR EMBL; AY263157; AAP78772.1; -; mRNA.
DR EMBL; AY236491; AAP69869.1; -; mRNA.
DR CCDS; CCDS40012.1; -. [Q7TQ69-1]
DR RefSeq; NP_808363.3; NM_177695.4.
DR AlphaFoldDB; Q7TQ69; -.
DR SMR; Q7TQ69; -.
DR STRING; 10090.ENSMUSP00000046028; -.
DR TCDB; 1.A.17.4.12; the calcium-dependent chloride channel (ca-clc) family.
DR GlyGen; Q7TQ69; 1 site.
DR iPTMnet; Q7TQ69; -.
DR PhosphoSitePlus; Q7TQ69; -.
DR PaxDb; Q7TQ69; -.
DR PRIDE; Q7TQ69; -.
DR ProteomicsDB; 259121; -. [Q7TQ69-1]
DR ProteomicsDB; 259122; -. [Q7TQ69-2]
DR DNASU; 233424; -.
DR GeneID; 233424; -.
DR KEGG; mmu:233424; -.
DR CTD; 342125; -.
DR MGI; MGI:2669033; Tmc3.
DR eggNOG; ENOG502QQGX; Eukaryota.
DR InParanoid; Q7TQ69; -.
DR OrthoDB; 1048914at2759; -.
DR PhylomeDB; Q7TQ69; -.
DR BioGRID-ORCS; 233424; 0 hits in 56 CRISPR screens.
DR PRO; PR:Q7TQ69; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q7TQ69; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR InterPro; IPR038900; TMC.
DR InterPro; IPR012496; TMC_dom.
DR PANTHER; PTHR23302; PTHR23302; 1.
DR Pfam; PF07810; TMC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1130
FT /note="Transmembrane channel-like protein 3"
FT /id="PRO_0000259603"
FT TOPO_DOM 1..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..319
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..361
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 383..393
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 415..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 531..570
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 571..591
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 592..619
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..680
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 681..701
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 702..1130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 742..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 723..725
FT /note="RSE -> SII (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12906855"
FT /id="VSP_052203"
FT VAR_SEQ 726..1130
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12906855"
FT /id="VSP_052204"
FT CONFLICT 248
FT /note="R -> K (in Ref. 2; AAP69869)"
FT /evidence="ECO:0000305"
FT CONFLICT 551
FT /note="P -> L (in Ref. 2; AAP69869)"
FT /evidence="ECO:0000305"
FT CONFLICT 695
FT /note="Missing (in Ref. 2; AAP69869)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1130 AA; 128691 MW; 9FE2B2D4FD501FE1 CRC64;
MKTSKASQRY RSIRRNASQC YLYQDSLLLG NSDDSFNADE TGDSSDPEQI FQNIQFQKDL
MANIRCRPWT MGQKLRALRR AKEIVLKFEG RLTRTRGYQA AGAELWRKFA RLACNFVVIF
IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG INIVLTVMTG AFVVLPELIA GQPFGSTASK
TIPREQITSA QDLDTVWSLG GYLQYSVLFY GYYGRERRIG RAGYRLPLAY FLVGMAVFAY
SFIVLLKRMA KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AILNSIREAI
LEEQEKKKNK NMAVTVCLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS KKELTLWEKN
EVSVVVSLVT MLAPSAFDLI AALEMYHPRT TLRFQLARVL VLYLGNLYSL IIALLDKVNS
MNIEEAATKN ITSHWADAPT FSATRTVPEE GQWPTPGSGA ELRRNTSTWV VEETSFLTSI
TPHTKANKTV PYMQGPQGQC WETYVGQEML KLSVIDMLFT VASILLIDFF RGLFVRYLSD
YWCWDLESKF PEYGEFKIAE NVLHLVYNQG MIWMGAFFSP CLPAFNVLKL IGLMYLRSWA
VLTCNVPHQQ VFRASRSNNF YLAMLLFMLF LCMLPTIFAI VHYKPSLNCG PFSGQEKIYD
IVSETIENDF PTWFHAVVGH ISSPVVILPA VLLLFMLIYY LQSIARSLKL SSQQLRMQIQ
NARSEDKKKV AQMVEALAIP SDARQAGSAT EAESSENSKP KTLQARIQTH EESSKRLLKD
SDLISQLSSV YMATSPNNGH MLNFDSLSSK SLRMEAITRS LPQSPGQGSR DPCSPLLDGS
RSRPEQDTNR HPHRPCSSTS NLHKNRSCSS VTQTQPLKDV RSEPLSRKDF QPISPPFCGS
GVSTLMTHDH SPRAPRYYVV NERDSHKKTH RAFWPERHFK IDALGDIVEL YPRNVQQYMS
WVPNQPCSPQ LSEEEEEMLR RDLVQWSIPA SSLTDLPRSS CFYTGDRSEN NTRDPKYQRR
VYYRSGDNSF EDQLERPTFV HRKPRSRNGQ YPQHALKARV KAKFEPSFTE SDSVSAASSS
DHQNSNNDQY LHVMSSQGRF PRSASQLGRR KAKSRQVLPT DLNDLICSNV
