BT3L4_HUMAN
ID BT3L4_HUMAN Reviewed; 158 AA.
AC Q96K17; B3KNJ1; D3DQ32; G3V1C6;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Transcription factor BTF3 homolog 4;
DE AltName: Full=Basic transcription factor 3-like 4;
GN Name=BTF3L4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Lung, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q96K17; Q9NRG4: SMYD2; NbExp=3; IntAct=EBI-6137496, EBI-1055671;
CC Q96K17; P40222: TXLNA; NbExp=6; IntAct=EBI-6137496, EBI-359793;
CC Q96K17; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-6137496, EBI-6116822;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96K17-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96K17-2; Sequence=VSP_044248;
CC Name=3;
CC IsoId=Q96K17-3; Sequence=VSP_045972, VSP_045973;
CC -!- SIMILARITY: Belongs to the NAC-beta family. {ECO:0000305}.
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DR EMBL; AK027750; BAB55342.1; -; mRNA.
DR EMBL; AK027582; BAG51353.1; -; mRNA.
DR EMBL; AL139156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL606761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06795.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06796.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06797.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06798.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06799.1; -; Genomic_DNA.
DR EMBL; BC022371; AAH22371.1; -; mRNA.
DR EMBL; BC070378; AAH70378.1; -; mRNA.
DR EMBL; BG536292; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS30713.1; -. [Q96K17-1]
DR CCDS; CCDS44146.1; -. [Q96K17-2]
DR CCDS; CCDS58001.1; -. [Q96K17-3]
DR RefSeq; NP_001129969.1; NM_001136497.2. [Q96K17-2]
DR RefSeq; NP_001230696.1; NM_001243767.1. [Q96K17-3]
DR RefSeq; NP_689478.1; NM_152265.4. [Q96K17-1]
DR AlphaFoldDB; Q96K17; -.
DR SMR; Q96K17; -.
DR BioGRID; 124828; 85.
DR IntAct; Q96K17; 10.
DR STRING; 9606.ENSP00000360664; -.
DR GlyGen; Q96K17; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96K17; -.
DR PhosphoSitePlus; Q96K17; -.
DR BioMuta; BTF3L4; -.
DR DMDM; 74751972; -.
DR EPD; Q96K17; -.
DR jPOST; Q96K17; -.
DR MassIVE; Q96K17; -.
DR MaxQB; Q96K17; -.
DR PaxDb; Q96K17; -.
DR PeptideAtlas; Q96K17; -.
DR PRIDE; Q96K17; -.
DR ProteomicsDB; 32328; -.
DR ProteomicsDB; 3502; -.
DR ProteomicsDB; 77024; -. [Q96K17-1]
DR TopDownProteomics; Q96K17-1; -. [Q96K17-1]
DR TopDownProteomics; Q96K17-2; -. [Q96K17-2]
DR Antibodypedia; 32991; 115 antibodies from 24 providers.
DR DNASU; 91408; -.
DR Ensembl; ENST00000313334.13; ENSP00000360664.4; ENSG00000134717.18. [Q96K17-1]
DR Ensembl; ENST00000472944.6; ENSP00000436712.1; ENSG00000134717.18. [Q96K17-2]
DR Ensembl; ENST00000489308.6; ENSP00000434824.1; ENSG00000134717.18. [Q96K17-3]
DR GeneID; 91408; -.
DR KEGG; hsa:91408; -.
DR MANE-Select; ENST00000313334.13; ENSP00000360664.4; NM_152265.5; NP_689478.1.
DR UCSC; uc001ctk.4; human. [Q96K17-1]
DR CTD; 91408; -.
DR GeneCards; BTF3L4; -.
DR HGNC; HGNC:30547; BTF3L4.
DR HPA; ENSG00000134717; Low tissue specificity.
DR neXtProt; NX_Q96K17; -.
DR OpenTargets; ENSG00000134717; -.
DR PharmGKB; PA142672545; -.
DR VEuPathDB; HostDB:ENSG00000134717; -.
DR eggNOG; KOG2240; Eukaryota.
DR GeneTree; ENSGT00940000154296; -.
DR HOGENOM; CLU_098726_3_0_1; -.
DR InParanoid; Q96K17; -.
DR OMA; HFKNPRV; -.
DR OrthoDB; 1435264at2759; -.
DR PhylomeDB; Q96K17; -.
DR TreeFam; TF317546; -.
DR PathwayCommons; Q96K17; -.
DR SignaLink; Q96K17; -.
DR BioGRID-ORCS; 91408; 187 hits in 1039 CRISPR screens.
DR ChiTaRS; BTF3L4; human.
DR GenomeRNAi; 91408; -.
DR Pharos; Q96K17; Tdark.
DR PRO; PR:Q96K17; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96K17; protein.
DR Bgee; ENSG00000134717; Expressed in cortical plate and 185 other tissues.
DR ExpressionAtlas; Q96K17; baseline and differential.
DR Genevisible; Q96K17; HS.
DR Gene3D; 2.20.70.30; -; 1.
DR InterPro; IPR039370; BTF3.
DR InterPro; IPR038187; NAC_A/B_dom_sf.
DR InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR PANTHER; PTHR10351; PTHR10351; 1.
DR Pfam; PF01849; NAC; 1.
DR SMART; SM01407; NAC; 1.
DR PROSITE; PS51151; NAC_AB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..158
FT /note="Transcription factor BTF3 homolog 4"
FT /id="PRO_0000213557"
FT DOMAIN 33..98
FT /note="NAC-A/B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00507"
FT REGION 122..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 5
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250|UniProtKB:P20290"
FT MOD_RES 111
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P20290"
FT VAR_SEQ 1..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044248"
FT VAR_SEQ 57..78
FT /note="VNMIKDDGTVIHFNNPKVQASL -> SWTVKHQNQKTLMRKMMMFQIL (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045972"
FT VAR_SEQ 79..158
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045973"
SQ SEQUENCE 158 AA; 17271 MW; 8C4AD058FB92D722 CRC64;
MNQEKLAKLQ AQVRIGGKGT ARRKKKVVHR TATADDKKLQ SSLKKLAVNN IAGIEEVNMI
KDDGTVIHFN NPKVQASLSA NTFAITGHAE AKPITEMLPG ILSQLGADSL TSLRKLAEQF
PRQVLDSKAP KPEDIDEEDD DVPDLVENFD EASKNEAN
