ID   TMC4_RAT                Reviewed;         698 AA.
AC   Q496Z4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Transmembrane channel-like protein 4;
GN   Name=Tmc4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable ion channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMC family. {ECO:0000305}.
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DR   EMBL; BC100657; AAI00658.1; -; mRNA.
DR   RefSeq; NP_001029276.1; NM_001034104.1.
DR   AlphaFoldDB; Q496Z4; -.
DR   STRING; 10116.ENSRNOP00000017074; -.
DR   PhosphoSitePlus; Q496Z4; -.
DR   PaxDb; Q496Z4; -.
DR   GeneID; 308310; -.
DR   KEGG; rno:308310; -.
DR   UCSC; RGD:1304811; rat.
DR   CTD; 147798; -.
DR   RGD; 1304811; Tmc4.
DR   eggNOG; ENOG502S3W0; Eukaryota.
DR   InParanoid; Q496Z4; -.
DR   OrthoDB; 1048914at2759; -.
DR   PhylomeDB; Q496Z4; -.
DR   PRO; PR:Q496Z4; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR   InterPro; IPR038900; TMC.
DR   InterPro; IPR012496; TMC_dom.
DR   PANTHER; PTHR23302; PTHR23302; 1.
DR   Pfam; PF07810; TMC; 1.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..698
FT                   /note="Transmembrane channel-like protein 4"
FT                   /id="PRO_0000289470"
FT   TOPO_DOM        1..154
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..334
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        356..380
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        402..411
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        433..469
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        491..517
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        539
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        540..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        561..578
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        579..599
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        600..639
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        640..660
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        661..698
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          74..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  78211 MW;  F49DEA80E8FBE9E6 CRC64;
     MEESPREAWA QFPAWSSSRK ARTGPSLASV LNDLPSAATL RYRGPGVLPW GTLDENDDEG
     RSLQAFAETA QMESQPSREL PWPMQARRAH RKSQAREQVA SGSESRAAYW TQQLSRTKGK
     MKEGFQTIQP WAWTLKKIGG QFGAGTESYF SLLRFLLFLN LGASVIEVCM KLIPTWLEGA
     PPGPPGPNIS SPCGSYIPHT QGLVTFPTQL FNLLSGEGYL EWSPLFYGFY PPRSNLAITY
     LCSVFAIGLI YLLFILHRSV SGLKETLLAE SDVLTSYSHR VFSAWNFGLC GDMHVRLRQR
     IILYELQVDL EEAAVRRRAT EQTLGQRVKV WSMRALLNLL VLALLGAAFY GIYWATEYTV
     TLQETPVVQQ TPLLKLLVNY LPSIFISVFN FVLPPAFTFI ASLEGYTHSR QIVLILLRTV
     FLRLASLVFL LFSLWNQITC GGNMEAEECK ACGYNYKEIP CWETRLGQEM YKLVLFDLLM
     GLLVTLLIQF PRKILCGLCP GALGRLSGTL EFQVPDEVLG LIYAQTVVWV GSFFCPLLPL
     INTAKFLILF WLKKITLFSI YSPASRTFRA STANFFFPLV LLVGLAISAV PVLYSIFLIP
     PSKLCGPFQG KLSIWAQIPE SIESLPQTAQ NFLYFLGTQA FTVPLLIVSS ILMMYTVALA
     NCYGRLISEL KRQIETEVQN KVFLAQRAVA LSSRNGVS