TMC5A_MOUSE
ID TMC5A_MOUSE Reviewed; 303 AA.
AC Q9D9D5; A2ARB1; Q9CVN5;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transmembrane and coiled-coil domain-containing protein 5A;
GN Name=Tmco5a; Synonyms=Tmco5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-246 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D9D5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D9D5-2; Sequence=VSP_028248;
CC -!- SIMILARITY: Belongs to the TMCO5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM20932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM20933.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK007078; BAB24853.1; -; mRNA.
DR EMBL; AK007251; BAB24916.1; -; mRNA.
DR EMBL; AL845318; CAM20932.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL845318; CAM20933.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL845318; CAM20934.1; -; Genomic_DNA.
DR EMBL; BC049568; AAH49568.1; -; mRNA.
DR CCDS; CCDS16569.1; -. [Q9D9D5-1]
DR RefSeq; NP_080380.1; NM_026104.4. [Q9D9D5-1]
DR RefSeq; XP_006500140.1; XM_006500077.2.
DR AlphaFoldDB; Q9D9D5; -.
DR SMR; Q9D9D5; -.
DR STRING; 10090.ENSMUSP00000028834; -.
DR iPTMnet; Q9D9D5; -.
DR PhosphoSitePlus; Q9D9D5; -.
DR PaxDb; Q9D9D5; -.
DR PRIDE; Q9D9D5; -.
DR ProteomicsDB; 259238; -. [Q9D9D5-1]
DR ProteomicsDB; 259239; -. [Q9D9D5-2]
DR Antibodypedia; 67483; 30 antibodies from 9 providers.
DR DNASU; 67356; -.
DR Ensembl; ENSMUST00000028834; ENSMUSP00000028834; ENSMUSG00000027355. [Q9D9D5-1]
DR GeneID; 67356; -.
DR KEGG; mmu:67356; -.
DR UCSC; uc008lre.2; mouse. [Q9D9D5-1]
DR UCSC; uc008lrf.2; mouse. [Q9D9D5-2]
DR CTD; 67356; -.
DR MGI; MGI:1914606; Tmco5.
DR VEuPathDB; HostDB:ENSMUSG00000027355; -.
DR eggNOG; ENOG502TDSB; Eukaryota.
DR GeneTree; ENSGT00940000153380; -.
DR HOGENOM; CLU_061400_0_0_1; -.
DR InParanoid; Q9D9D5; -.
DR OMA; RGILWKL; -.
DR OrthoDB; 1219753at2759; -.
DR PhylomeDB; Q9D9D5; -.
DR TreeFam; TF337140; -.
DR BioGRID-ORCS; 67356; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q9D9D5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D9D5; protein.
DR Bgee; ENSMUSG00000027355; Expressed in spermatid and 23 other tissues.
DR ExpressionAtlas; Q9D9D5; baseline and differential.
DR Genevisible; Q9D9D5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026617; SMCO2/5.
DR PANTHER; PTHR22422; PTHR22422; 1.
DR Pfam; PF14992; TMCO5; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..303
FT /note="Transmembrane and coiled-coil domain-containing
FT protein 5A"
FT /id="PRO_0000305154"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 25..204
FT /evidence="ECO:0000255"
FT VAR_SEQ 163..182
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028248"
SQ SEQUENCE 303 AA; 35854 MW; D4AA3952B5C10586 CRC64;
MEEQKENQLD YESEKMEILR LAQSKKNIIS LNMDLERDMQ RIDEANQELL LEIQEKENEI
QRLEHEITQT GNPAEDEEWE KENYTVMERE QALQELEEET ARLERKNETL VHSISELQRK
LTRKSQKVIR YEQGDLETTP EESKVKLQQL ESSCADQEKE LGKIMEDYVF VSQLCEDQAL
CIKKYQEALK RIEEELETGY LEREVSKVLS MDSERERSTS LNKMDGFISK GALRFSKSIF
RSLLFSTLFF IRLLGYLIFH LSFINPDLLV NALPKILSRD VLWKLRCFLF PSLTLETEDM
LPH
