ID   TMC5B_HUMAN             Reviewed;         307 AA.
AC   A8MYB1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Transmembrane and coiled-coil domain-containing protein 5B;
GN   Name=TMCO5B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMCO5 family. {ECO:0000305}.
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DR   EMBL; AC055874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MYB1; -.
DR   SMR; A8MYB1; -.
DR   BioMuta; HGNC:34243; -.
DR   jPOST; A8MYB1; -.
DR   PeptideAtlas; A8MYB1; -.
DR   PRIDE; A8MYB1; -.
DR   ProteomicsDB; 2389; -.
DR   GeneCards; TMCO5B; -.
DR   HGNC; HGNC:34243; TMCO5B.
DR   neXtProt; NX_A8MYB1; -.
DR   InParanoid; A8MYB1; -.
DR   PhylomeDB; A8MYB1; -.
DR   Pharos; A8MYB1; Tdark.
DR   PRO; PR:A8MYB1; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A8MYB1; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026617; SMCO2/5.
DR   PANTHER; PTHR22422; PTHR22422; 1.
DR   Pfam; PF14992; TMCO5; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Transmembrane and coiled-coil domain-containing
FT                   protein 5B"
FT                   /id="PRO_0000339347"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          17..207
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  35763 MW;  A5C6B7A9032BB2C8 CRC64;
     MEDVGQNPLD DVKNIFFASS LEAVKQNLDC LNSDLEKDLQ KLDMENQVLL RKIKEKEETI
     SSLERKLALS LEEAKEEEEL NYVIDEQEES LRELELETAK LEKSNAILSR NVVEVQKKIS
     GLFTNIGLEE ETTKQILEEM KARLQKSTES CAKQEEELAK IESDYQSVSD LCKDQVYYIK
     KYQEVLRKMK EEKETLLLEK QISKAQDDSS QTVKPGSILA DTTQRNMERT TIKKQERRCW
     YKYFQYLTFM VLVFIRLLAY VIFHLQYINP DLLVDVLPLV LSRGTLESLR KVSHPFLTLA
     VEEALPH