TMC5B_MOUSE
ID TMC5B_MOUSE Reviewed; 307 AA.
AC Q80X59; Q9D4S7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Transmembrane and coiled-coil domain-containing protein 5B;
GN Name=Tmco5b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMCO5 family. {ECO:0000305}.
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DR EMBL; AK016214; BAB30151.1; -; mRNA.
DR EMBL; AL929450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050803; AAH50803.1; -; mRNA.
DR CCDS; CCDS16558.1; -.
DR RefSeq; NP_083508.1; NM_029232.2.
DR AlphaFoldDB; Q80X59; -.
DR SMR; Q80X59; -.
DR STRING; 10090.ENSMUSP00000042247; -.
DR EPD; Q80X59; -.
DR PaxDb; Q80X59; -.
DR PRIDE; Q80X59; -.
DR ProteomicsDB; 259123; -.
DR DNASU; 75275; -.
DR Ensembl; ENSMUST00000040856; ENSMUSP00000042247; ENSMUSG00000041255.
DR GeneID; 75275; -.
DR KEGG; mmu:75275; -.
DR UCSC; uc008lpj.1; mouse.
DR CTD; 100652857; -.
DR MGI; MGI:1922525; Tmco5b.
DR VEuPathDB; HostDB:ENSMUSG00000041255; -.
DR eggNOG; ENOG502SXU7; Eukaryota.
DR GeneTree; ENSGT00940000153380; -.
DR HOGENOM; CLU_061400_0_0_1; -.
DR InParanoid; Q80X59; -.
DR OMA; FRCLVFM; -.
DR OrthoDB; 1251437at2759; -.
DR PhylomeDB; Q80X59; -.
DR TreeFam; TF337140; -.
DR BioGRID-ORCS; 75275; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Tmco5b; mouse.
DR PRO; PR:Q80X59; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80X59; protein.
DR Bgee; ENSMUSG00000041255; Expressed in spermatid and 6 other tissues.
DR Genevisible; Q80X59; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026617; SMCO2/5.
DR PANTHER; PTHR22422; PTHR22422; 1.
DR Pfam; PF14992; TMCO5; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..307
FT /note="Transmembrane and coiled-coil domain-containing
FT protein 5B"
FT /id="PRO_0000305156"
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 20..212
FT /evidence="ECO:0000255"
FT CONFLICT 101
FT /note="L -> P (in Ref. 1; BAB30151)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 36059 MW; A2E45D622BF16D7E CRC64;
MEDAGQNPLD DEAEITEIPT LEAIKQNLKY LNSDLEKDLQ RLDEANQILL RKIQKKEESI
QSLERDIALS IGRVPERDDF NEILAQKETA LKDLELESAK LEKKNKTLSK NVMELQKKIS
KGLKNIASDP ETLKKKVTEF KVKLQKSTES CAQQEKEIAK MESDYQSVFQ LCEDQAHYIK
KYQEILREME KEKEVMLLEK EISKAQNDSS QVVKPGSTLV ETIQSNMEKN IIKKQKRKFW
LRHFRYLFFM VMIVIRLLGY VFFHLQYVNP DFLVDTLPML MSRSSLKWLR DILFPFLTLE
VEDVLPH
