TMC6_HUMAN
ID TMC6_HUMAN Reviewed; 805 AA.
AC Q7Z403; O43284; Q45VJ2; Q8IU98; Q8IUI7; Q8IWU8; Q8TEQ7; Q9HAG5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Transmembrane channel-like protein 6;
DE AltName: Full=Epidermodysplasia verruciformis protein 1;
DE AltName: Full=Protein LAK-4;
GN Name=TMC6; Synonyms=EVER1, EVIN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION,
RP INVOLVEMENT IN EV1, AND VARIANT ARG-125.
RX PubMed=12426567; DOI=10.1038/ng1044;
RA Ramoz N., Rueda L.-A., Bouadjar B., Montoya L.-S., Orth G., Favre M.;
RT "Mutations in two adjacent novel genes are associated with
RT epidermodysplasia verruciformis.";
RL Nat. Genet. 32:579-581(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12906855; DOI=10.1016/s0888-7543(03)00154-x;
RA Kurima K., Yang Y., Sorber K., Griffith A.J.;
RT "Characterization of the transmembrane channel-like (TMC) gene family:
RT functional clues from hearing loss and epidermodysplasia verruciformis.";
RL Genomics 82:300-308(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND TISSUE SPECIFICITY.
RA Lin L., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M.,
RA Wen S., Li H., Yang S.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PHE-153.
RC TISSUE=B-cell, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 345-805.
RC TISSUE=Lymphoid tissue;
RA Abe Y., Takaoka Y.;
RT "LAK-4 clone from the membrane lymphotoxin expressing subtraction
RT library.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP INVOLVEMENT IN EV1.
RX PubMed=15042430; DOI=10.1007/s10038-004-0135-6;
RA Tate G., Suzuki T., Kishimoto K., Mitsuya T.;
RT "Novel mutations of EVER1/TMC6 gene in a Japanese patient with
RT epidermodysplasia verruciformis.";
RL J. Hum. Genet. 49:223-225(2004).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-89 AND THR-105, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-94, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [11]
RP INTERACTION WITH CIB1.
RX PubMed=30068544; DOI=10.1084/jem.20170308;
RA de Jong S.J., Crequer A., Matos I., Hum D., Gunasekharan V., Lorenzo L.,
RA Jabot-Hanin F., Imahorn E., Arias A.A., Vahidnezhad H., Youssefian L.,
RA Markle J.G., Patin E., D'Amico A., Wang C.Q.F., Full F., Ensser A.,
RA Leisner T.M., Parise L.V., Bouaziz M., Maya N.P., Cadena X.R., Saka B.,
RA Saeidian A.H., Aghazadeh N., Zeinali S., Itin P., Krueger J.G., Laimins L.,
RA Abel L., Fuchs E., Uitto J., Franco J.L., Burger B., Orth G., Jouanguy E.,
RA Casanova J.L.;
RT "The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity
RT to beta-papillomaviruses.";
RL J. Exp. Med. 215:2289-2310(2018).
CC -!- FUNCTION: Probable ion channel. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CIB1. {ECO:0000269|PubMed:30068544}.
CC -!- INTERACTION:
CC Q7Z403; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-9088037, EBI-1055254;
CC Q7Z403; P16284: PECAM1; NbExp=3; IntAct=EBI-9088037, EBI-716404;
CC Q7Z403; P08670: VIM; NbExp=3; IntAct=EBI-9088037, EBI-353844;
CC Q7Z403; Q8N680: ZBTB2; NbExp=3; IntAct=EBI-9088037, EBI-2515601;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:12426567}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12426567}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Large EVER1;
CC IsoId=Q7Z403-1; Sequence=Displayed;
CC Name=2; Synonyms=Small EVER1;
CC IsoId=Q7Z403-2; Sequence=VSP_016439;
CC Name=3;
CC IsoId=Q7Z403-3; Sequence=VSP_016437, VSP_016440;
CC Name=4;
CC IsoId=Q7Z403-4; Sequence=VSP_016438, VSP_016441, VSP_016442;
CC -!- TISSUE SPECIFICITY: Expressed in placenta, prostate, testis, activated
CC T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.
CC {ECO:0000269|PubMed:12906855, ECO:0000269|Ref.3}.
CC -!- DISEASE: Epidermodysplasia verruciformis 1 (EV1) [MIM:226400]: A form
CC of epidermodysplasia verruciformis, a rare genodermatosis associated
CC with a high risk of skin carcinoma that results from an abnormal
CC susceptibility to infection by specific human papillomaviruses,
CC including the oncogenic HPV5. Infection leads to the early development
CC of disseminated flat wart-like and pityriasis versicolor-like skin
CC lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous
CC cell carcinomas develop in about half of the patients, mainly on sun-
CC exposed skin areas. EV1 inheritance is autosomal recessive.
CC {ECO:0000269|PubMed:12426567, ECO:0000269|PubMed:15042430}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the TMC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA24179.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB84891.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=TMC6base; Note=TMC6 mutation db;
CC URL="http://structure.bmc.lu.se/idbase/TMC6base/";
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DR EMBL; AY057379; AAL25836.1; -; mRNA.
DR EMBL; AY099356; AAM44452.1; -; mRNA.
DR EMBL; AY099357; AAM44453.1; -; mRNA.
DR EMBL; AY236496; AAP69874.1; -; mRNA.
DR EMBL; DQ104440; AAZ20186.1; -; mRNA.
DR EMBL; AK021738; BAB13884.1; -; mRNA.
DR EMBL; AK074065; BAB84891.1; ALT_INIT; mRNA.
DR EMBL; BC023597; AAH23597.1; -; mRNA.
DR EMBL; BC035648; AAH35648.1; ALT_INIT; mRNA.
DR EMBL; AB002405; BAA24179.2; ALT_INIT; mRNA.
DR CCDS; CCDS32748.1; -. [Q7Z403-1]
DR RefSeq; NP_001120670.1; NM_001127198.2. [Q7Z403-1]
DR RefSeq; NP_001308114.1; NM_001321185.1. [Q7Z403-1]
DR RefSeq; NP_009198.4; NM_007267.7. [Q7Z403-1]
DR RefSeq; XP_005257052.1; XM_005256995.1.
DR RefSeq; XP_011522557.1; XM_011524255.1. [Q7Z403-1]
DR AlphaFoldDB; Q7Z403; -.
DR BioGRID; 116453; 37.
DR IntAct; Q7Z403; 10.
DR MINT; Q7Z403; -.
DR STRING; 9606.ENSP00000465261; -.
DR TCDB; 1.A.17.4.10; the calcium-dependent chloride channel (ca-clc) family.
DR GlyGen; Q7Z403; 2 sites.
DR iPTMnet; Q7Z403; -.
DR PhosphoSitePlus; Q7Z403; -.
DR SwissPalm; Q7Z403; -.
DR BioMuta; TMC6; -.
DR DMDM; 83305925; -.
DR EPD; Q7Z403; -.
DR jPOST; Q7Z403; -.
DR MassIVE; Q7Z403; -.
DR MaxQB; Q7Z403; -.
DR PaxDb; Q7Z403; -.
DR PeptideAtlas; Q7Z403; -.
DR PRIDE; Q7Z403; -.
DR ProteomicsDB; 69106; -. [Q7Z403-1]
DR ProteomicsDB; 69107; -. [Q7Z403-2]
DR ProteomicsDB; 69108; -. [Q7Z403-3]
DR ProteomicsDB; 69109; -. [Q7Z403-4]
DR Antibodypedia; 32516; 138 antibodies from 23 providers.
DR DNASU; 11322; -.
DR Ensembl; ENST00000306591.11; ENSP00000306405.6; ENSG00000141524.17. [Q7Z403-2]
DR Ensembl; ENST00000322914.7; ENSP00000313408.2; ENSG00000141524.17. [Q7Z403-1]
DR Ensembl; ENST00000392467.7; ENSP00000376260.2; ENSG00000141524.17. [Q7Z403-1]
DR Ensembl; ENST00000589553.5; ENSP00000465359.1; ENSG00000141524.17. [Q7Z403-4]
DR Ensembl; ENST00000590602.6; ENSP00000465261.1; ENSG00000141524.17. [Q7Z403-1]
DR Ensembl; ENST00000591436.5; ENSP00000464853.1; ENSG00000141524.17. [Q7Z403-3]
DR GeneID; 11322; -.
DR KEGG; hsa:11322; -.
DR MANE-Select; ENST00000590602.6; ENSP00000465261.1; NM_001127198.5; NP_001120670.1.
DR UCSC; uc002jui.2; human. [Q7Z403-1]
DR CTD; 11322; -.
DR DisGeNET; 11322; -.
DR GeneCards; TMC6; -.
DR HGNC; HGNC:18021; TMC6.
DR HPA; ENSG00000141524; Tissue enhanced (lymphoid).
DR MalaCards; TMC6; -.
DR MIM; 226400; phenotype.
DR MIM; 605828; gene.
DR neXtProt; NX_Q7Z403; -.
DR OpenTargets; ENSG00000141524; -.
DR Orphanet; 302; Epidermodysplasia verruciformis.
DR PharmGKB; PA134949466; -.
DR VEuPathDB; HostDB:ENSG00000141524; -.
DR eggNOG; KOG1039; Eukaryota.
DR GeneTree; ENSGT01050000244894; -.
DR HOGENOM; CLU_606852_0_0_1; -.
DR InParanoid; Q7Z403; -.
DR OMA; MWSIKPS; -.
DR PhylomeDB; Q7Z403; -.
DR PathwayCommons; Q7Z403; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q7Z403; -.
DR BioGRID-ORCS; 11322; 14 hits in 1074 CRISPR screens.
DR ChiTaRS; TMC6; human.
DR GeneWiki; TMC6; -.
DR GenomeRNAi; 11322; -.
DR Pharos; Q7Z403; Tbio.
DR PRO; PR:Q7Z403; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q7Z403; protein.
DR Bgee; ENSG00000141524; Expressed in granulocyte and 188 other tissues.
DR ExpressionAtlas; Q7Z403; baseline and differential.
DR Genevisible; Q7Z403; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0031965; C:nuclear membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR InterPro; IPR038900; TMC.
DR InterPro; IPR012496; TMC_dom.
DR PANTHER; PTHR23302; PTHR23302; 1.
DR Pfam; PF07810; TMC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Methylation; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..805
FT /note="Transmembrane channel-like protein 6"
FT /id="PRO_0000185384"
FT TOPO_DOM 1..209
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..338
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..431
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 453..469
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 491..505
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 527..553
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 575..604
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 626..650
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 672..722
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 723..743
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 744..805
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 89
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 94
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 105
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..361
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_016437"
FT VAR_SEQ 1..227
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016438"
FT VAR_SEQ 410..760
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12426567"
FT /id="VSP_016439"
FT VAR_SEQ 512..571
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_016440"
FT VAR_SEQ 513..525
FT /note="NLILKLAILGTLC -> CVAAHENIIWCWS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016441"
FT VAR_SEQ 526..805
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016442"
FT VARIANT 125
FT /note="W -> R (in dbSNP:rs2748427)"
FT /evidence="ECO:0000269|PubMed:12426567"
FT /id="VAR_023963"
FT VARIANT 153
FT /note="L -> F (in dbSNP:rs12449858)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052336"
FT VARIANT 191
FT /note="G -> D (in dbSNP:rs34712518)"
FT /id="VAR_061851"
FT CONFLICT 266
FT /note="L -> P (in Ref. 2; AAP69874)"
FT /evidence="ECO:0000305"
FT CONFLICT 274..277
FT /note="QVAF -> PRVR (in Ref. 6; AAH35648)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="D -> G (in Ref. 2; AAP69874)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 805 AA; 90045 MW; 9A9A5C43FBA86AD4 CRC64;
MAQPLAFILD VPETPGDQGQ GPSPYDESEV HDSFQQLIQE QSQCTAQEGL ELQQREREVT
GSSQQTLWRP EGTQSTATLR ILASMPSRTI GRSRGAIISQ YYNRTVQLRC RSSRPLLGNF
VRSAWPSLRL YDLELDPTAL EEEEKQSLLV KELQSLAVAQ RDHMLRGMPL SLAEKRSLRE
KSRTPRGKWR GQPGSGGVCS CCGRLRYACV LALHSLGLAL LSALQALMPW RYALKRIGGQ
FGSSVLSYFL FLKTLLAFNA LLLLLLVAFI MGPQVAFPPA LPGPAPVCTG LELLTGAGCF
THTVMYYGHY SNATLNQPCG SPLDGSQCTP RVGGLPYNMP LAYLSTVGVS FFITCITLVY
SMAHSFGESY RVGSTSGIHA ITVFCSWDYK VTQKRASRLQ QDNIRTRLKE LLAEWQLRHS
PRSVCGRLRQ AAVLGLVWLL CLGTALGCAV AVHVFSEFMI QSPEAAGQEA VLLVLPLVVG
LLNLGAPYLC RVLAALEPHD SPVLEVYVAI CRNLILKLAI LGTLCYHWLG RRVGVLQGQC
WEDFVGQELY RFLVMDFVLM LLDTLFGELV WRIISEKKLK RRRKPEFDIA RNVLELIYGQ
TLTWLGVLFS PLLPAVQIIK LLLVFYVKKT SLLANCQAPR RPWLASHMST VFLTLLCFPA
FLGAAVFLCY AVWQVKPSST CGPFRTLDTM YEAGRVWVRH LEAAGPRVSW LPWVHRYLME
NTFFVFLVSA LLLAVIYLNI QVVRGQRKVI CLLKEQISNE GEDKIFLINK LHSIYERKER
EERSRVGTTE EAAAPPALLT DEQDA
