ID   TMC7_CHICK              Reviewed;         735 AA.
AC   Q5YCC5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transmembrane channel-like protein 7;
GN   Name=Tmc7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Inner ear;
RX   PubMed=15857715; DOI=10.1016/j.neuroscience.2005.01.046;
RA   Mutai H., Mann S., Heller S.;
RT   "Identification of chicken transmembrane channel-like (TMC) genes:
RT   expression analysis in the cochlea.";
RL   Neuroscience 132:1115-1122(2005).
CC   -!- FUNCTION: Probable ion channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMC family. {ECO:0000305}.
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DR   EMBL; AY581312; AAT85603.1; -; mRNA.
DR   AlphaFoldDB; Q5YCC5; -.
DR   STRING; 9031.ENSGALP00000011144; -.
DR   PaxDb; Q5YCC5; -.
DR   VEuPathDB; HostDB:geneid_416610; -.
DR   eggNOG; ENOG502QPM8; Eukaryota.
DR   InParanoid; Q5YCC5; -.
DR   PhylomeDB; Q5YCC5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR   InterPro; IPR038900; TMC.
DR   InterPro; IPR012496; TMC_dom.
DR   PANTHER; PTHR23302; PTHR23302; 1.
DR   Pfam; PF07810; TMC; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..735
FT                   /note="Transmembrane channel-like protein 7"
FT                   /id="PRO_0000287168"
FT   TOPO_DOM        1..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..355
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        377..403
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        425..436
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        458..488
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        510..548
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        549..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        570..594
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        595..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        616..634
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        635..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        656..658
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        659..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        680..735
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          710..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        385
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   735 AA;  84377 MW;  C7813D342778D3C6 CRC64;
     MSEFGAGAEL PGWVTESRSR GEFFSPEESH AAAPAGFLQE LPSYRSVLWR RAAAGDVQER
     WGNLRGIASA ERREPQPDGG ERGAIPLWEL PFSIAEKRDS QQGDIKYSSG WNHWKRTSSK
     SWKKALKDIK ELSSYMQLWR HDIHSIEGKF GTGIQSYFSF LRFLVLLNFL MFILMFSFVT
     LPAVISNYGI FNSSSTKISP NNTEPYCTVY TPSGNKGLVY FYTYLKDLLT GTGFLEVTVL
     FYGYYTIDAA WFSVLRYNLP LAYLLTTFAY LALSFVWIIK RSVERFRQHL VDDEDQFQSY
     CNKVFAGWDF CITDLNAARL KHRSLLYELQ TNLEEERLKQ KIAERTMKEK LQIYSLRIFI
     NIIVIAVLSG CFYSIYRATV FSQENSSVSI RRNVMIANLL VQYLPSIVIT SANFIAPQIF
     SFLIRFEDYS AAFEIRLTLI RCVFVRLANV GVLLFSLWSQ IHCDNDQCKA CGYDYELYPC
     WESAVGQEMY KLLIFDFMII IAMTLFVDFP RKLLVTYCSW KLVQWWGLQE FGISDNVLEI
     IYGQTICWIG TFFSPLLPAI ATIKYFIIFY IKKISLIHTR KPASRPIRAS SSNFFFLAVL
     LIGLILAFVP LGVSIALISS SKACGPFRNF NTSWAIVPYT ILEFPIGLQK FLYGIASEAF
     AVPFFVIACL FMFYFIALAG AHKRVVEQLR EQLVTESRDK LFLLEKLSEA QKNSGKPQKA
     RKLTSSWLLE PLDKG