TMC7_MOUSE
ID TMC7_MOUSE Reviewed; 726 AA.
AC Q8C428; Q7TN59; Q7TQ66; Q8C4C3;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transmembrane channel-like protein 7;
GN Name=Tmc7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12812529; DOI=10.1186/1471-2164-4-24;
RA Keresztes G., Mutai H., Heller S.;
RT "TMC and EVER genes belong to a larger novel family, the TMC gene family
RT encoding transmembrane proteins.";
RL BMC Genomics 4:24-24(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12906855; DOI=10.1016/s0888-7543(03)00154-x;
RA Kurima K., Yang Y., Sorber K., Griffith A.J.;
RT "Characterization of the transmembrane channel-like (TMC) gene family:
RT functional clues from hearing loss and epidermodysplasia verruciformis.";
RL Genomics 82:300-308(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Probable ion channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C428-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C428-2; Sequence=VSP_025348;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:12812529}.
CC -!- SIMILARITY: Belongs to the TMC family. {ECO:0000305}.
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DR EMBL; AY263161; AAP78776.1; -; mRNA.
DR EMBL; AY236499; AAP69877.1; -; mRNA.
DR EMBL; AK082562; BAC38531.1; -; mRNA.
DR EMBL; AK083189; BAC38802.1; -; mRNA.
DR CCDS; CCDS21772.1; -. [Q8C428-1]
DR RefSeq; NP_766064.2; NM_172476.4. [Q8C428-1]
DR AlphaFoldDB; Q8C428; -.
DR SMR; Q8C428; -.
DR STRING; 10090.ENSMUSP00000046927; -.
DR GlyGen; Q8C428; 3 sites.
DR iPTMnet; Q8C428; -.
DR PhosphoSitePlus; Q8C428; -.
DR PaxDb; Q8C428; -.
DR PRIDE; Q8C428; -.
DR ProteomicsDB; 259246; -. [Q8C428-1]
DR ProteomicsDB; 259247; -. [Q8C428-2]
DR Antibodypedia; 25317; 56 antibodies from 19 providers.
DR DNASU; 209760; -.
DR Ensembl; ENSMUST00000044195; ENSMUSP00000046927; ENSMUSG00000042246. [Q8C428-1]
DR GeneID; 209760; -.
DR KEGG; mmu:209760; -.
DR UCSC; uc009jka.1; mouse. [Q8C428-1]
DR CTD; 79905; -.
DR MGI; MGI:2443317; Tmc7.
DR VEuPathDB; HostDB:ENSMUSG00000042246; -.
DR eggNOG; ENOG502QPM8; Eukaryota.
DR GeneTree; ENSGT01050000244894; -.
DR HOGENOM; CLU_013958_1_0_1; -.
DR InParanoid; Q8C428; -.
DR OMA; IMQIKAM; -.
DR OrthoDB; 1048914at2759; -.
DR PhylomeDB; Q8C428; -.
DR TreeFam; TF313462; -.
DR BioGRID-ORCS; 209760; 7 hits in 75 CRISPR screens.
DR ChiTaRS; Tmc7; mouse.
DR PRO; PR:Q8C428; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C428; protein.
DR Bgee; ENSMUSG00000042246; Expressed in extra-ocular muscle and 199 other tissues.
DR Genevisible; Q8C428; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR InterPro; IPR038900; TMC.
DR InterPro; IPR012496; TMC_dom.
DR PANTHER; PTHR23302; PTHR23302; 1.
DR Pfam; PF07810; TMC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..726
FT /note="Transmembrane channel-like protein 7"
FT /id="PRO_0000287167"
FT TOPO_DOM 1..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..492
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..553
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 575..598
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 620..663
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 685..726
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z402"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 636
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 517..726
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025348"
FT CONFLICT 447
FT /note="F -> I (in Ref. 2; AAP69877)"
FT /evidence="ECO:0000305"
FT CONFLICT 691..692
FT /note="VV -> AA (in Ref. 1; AAP78776)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 726 AA; 83337 MW; 89C397C9CAD5CE59 CRC64;
MSEGSAGDPG HGSSRQRAVH PENLSLGSSC FSPPVNFLQE LPSYRSVARR RTNILSRDKQ
SGTLLKPTDS FSCQLDGGIT ENLNSQSIRK YALNISEKRR LRDIQETQMK YLSEWDQWKR
YSSKSWKRFL EKAREMTTHL ELWRKDIRSI EGKFGTGIQS YFSFLRFLVV LNLVIFLIIF
MLVLLPILLT KYKITNSTFV LIPFKDMDIQ CTLYPISSSG LIYFYSYIID LLSGTGFLEE
TSLFYGHYTI DGVKFQSFTY DLPLAYLIST IAYLALSLLW IVKRSVEGFK INLIRSEEHF
QSYCNKIFAG WDFCITNRSM AELKHSSLRY ELRADLEEER IRQKIAERTS EETIRIYTLR
LFLNCIVLAV LAACFYAIYL ATAFSQEHMK KEIDKMVFGE NLLILYLPSI VITLANFITP
IIFAKIIHYE DYSPGFEIRL TILRCVFMRL ATICVLVFTL GSKITSCGDS TCELCGYNQK
LYPCWETQVG QEMYKLMIFD FIIILAVTLF VDFPRKLLVT YCASSKLIQC WGQQEFAIPD
NVLGIVYGQT ICWIGAFFSP LLPAIATLKF VIIFYVKELS LLYTCRPSPR QFRASNSNFF
FLLVLLIGLC LAIIPLTISM ARIPSSKACG PFTNFNTTWE VIPQTVSTFP SSLQTLIHAV
TSEAFAVPFF MIICLVMFYF IALAGAHKQV VVQLREQLSL ESRDKRYLIQ KLTEAQREVR
SQPASA
