BTB6B_DANRE
ID BTB6B_DANRE Reviewed; 482 AA.
AC Q5TZE1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=BTB/POZ domain-containing protein 6-B;
GN Name=btbd6b; Synonyms=btbd6; ORFNames=si:dkey-11b8.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=20080956; DOI=10.1101/gad.554510;
RA Sobieszczuk D.F., Poliakov A., Xu Q., Wilkinson D.G.;
RT "A feedback loop mediated by degradation of an inhibitor is required to
RT initiate neuronal differentiation.";
RL Genes Dev. 24:206-218(2010).
CC -!- FUNCTION: Adapter protein for the cul3 E3 ubiquitin-protein ligase
CC complex. Promotes the export of zbtb16/plzf from the nucleus to the
CC cytoplasm and targets zbtb16/plzf for ubiquitination and degradation.
CC Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote
CC neurogenesis (By similarity). {ECO:0000250|UniProtKB:A9JRD8}.
CC -!- SUBUNIT: Interacts with cul3. Interacts (via BTB domain) with
CC zbtb16/plzf (By similarity). {ECO:0000250|UniProtKB:A9JRD8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A9JRD8}. Nucleus
CC {ECO:0000250|UniProtKB:A9JRD8}. Note=Present mainly, but not excusively
CC in the cytoplasm. {ECO:0000250|UniProtKB:A9JRD8}.
CC -!- TISSUE SPECIFICITY: In embryos, expressed in the cranial ganglia.
CC {ECO:0000269|PubMed:20080956}.
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DR EMBL; BX255905; CAH68989.1; -; Genomic_DNA.
DR EMBL; BX321888; CAK11390.1; -; Genomic_DNA.
DR EMBL; BC124114; AAI24115.1; -; mRNA.
DR RefSeq; NP_001019986.1; NM_001024815.2.
DR AlphaFoldDB; Q5TZE1; -.
DR SMR; Q5TZE1; -.
DR STRING; 7955.ENSDARP00000039906; -.
DR PaxDb; Q5TZE1; -.
DR Ensembl; ENSDART00000039907; ENSDARP00000039906; ENSDARG00000032369.
DR Ensembl; ENSDART00000192629; ENSDARP00000153969; ENSDARG00000114044.
DR GeneID; 553533; -.
DR KEGG; dre:553533; -.
DR CTD; 553533; -.
DR ZFIN; ZDB-GENE-030829-65; btbd6b.
DR eggNOG; KOG2075; Eukaryota.
DR GeneTree; ENSGT00940000155720; -.
DR HOGENOM; CLU_015899_2_1_1; -.
DR InParanoid; Q5TZE1; -.
DR OMA; GQSEIHI; -.
DR OrthoDB; 660286at2759; -.
DR PhylomeDB; Q5TZE1; -.
DR TreeFam; TF106482; -.
DR Reactome; R-DRE-8951664; Neddylation.
DR Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q5TZE1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000032369; Expressed in brain and 29 other tissues.
DR ExpressionAtlas; Q5TZE1; baseline.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR Gene3D; 2.60.120.820; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR012983; PHR.
DR InterPro; IPR038648; PHR_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF08005; PHR; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Nucleus;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..482
FT /note="BTB/POZ domain-containing protein 6-B"
FT /id="PRO_0000380248"
FT DOMAIN 80..150
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ SEQUENCE 482 AA; 53273 MW; 95F9B2F98DCF7F2B CRC64;
MAAELYPASI NTNLPNSNST AVTAASKKTI VQVTQTVTTP TTTATQQNIN NNNVETASWQ
STHPTLRERN ALMFNNELMA DVHFVVGPPG ASQKVPAHKY VLAVGSSVFG AMFYGDLAEG
ESEIHIPDVE PAAFLILLKY MYSDEIELEA DTVLATLYAA KKYIVPALAK ACVTFLETSL
EAKNACVLLS QSRLFEEPEL TLRCWEVIDA QAELALHSEG FCEIDLQTLE IILKRETLNT
REAVVFQAAL DWAVAECKRQ GLGPTARNKR AVLGKALYLV RIPTMTLEEF ANGAAQSDVL
TLEETHDVFL WYTAANKPKL EFPLQKRKGL TPQRCHRFQS SAYRSNQWRY RGRCDSIQFA
VDKRIFIAGL GLYGSSGGKA EYSVKIELKR QGVTLAQNLT KFISDGSSNT FSVWFEHPVQ
VEQDTFYTVS AVLDGNELSY FGQEGMTEVQ CGKVTFQFQC SSDSTNGTGV QGGQIPELVF
YA
