TMCO1_CAEEL
ID TMCO1_CAEEL Reviewed; 186 AA.
AC Q19714;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Calcium load-activated calcium channel homolog {ECO:0000250|UniProtKB:Q9UM00};
DE Short=CLAC channel {ECO:0000250|UniProtKB:Q9UM00};
GN ORFNames=F22B5.10 {ECO:0000312|WormBase:F22B5.10};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=27212239; DOI=10.1016/j.cell.2016.04.051;
RA Wang Q.C., Zheng Q., Tan H., Zhang B., Li X., Yang Y., Yu J., Liu Y.,
RA Chai H., Wang X., Sun Z., Wang J.Q., Zhu S., Wang F., Yang M., Guo C.,
RA Wang H., Zheng Q., Li Y., Chen Q., Zhou A., Tang T.S.;
RT "TMCO1 is an ER Ca(2+) load-activated Ca(2+) channel.";
RL Cell 165:1454-1466(2016).
CC -!- FUNCTION: Calcium-selective channel required to prevent calcium stores
CC from overfilling. {ECO:0000305|PubMed:27212239}.
CC -!- SUBUNIT: Homodimer and homotetramer. {ECO:0000250|UniProtKB:Q9UM00}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9UM00}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9UM00}.
CC -!- SIMILARITY: Belongs to the TMCO1 family. {ECO:0000305}.
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DR EMBL; BX284602; CAA90361.1; -; Genomic_DNA.
DR PIR; T21243; T21243.
DR RefSeq; NP_495786.1; NM_063385.5.
DR AlphaFoldDB; Q19714; -.
DR SMR; Q19714; -.
DR STRING; 6239.F22B5.10; -.
DR EPD; Q19714; -.
DR PaxDb; Q19714; -.
DR PeptideAtlas; Q19714; -.
DR EnsemblMetazoa; F22B5.10.1; F22B5.10.1; WBGene00009045.
DR GeneID; 174352; -.
DR KEGG; cel:CELE_F22B5.10; -.
DR UCSC; F22B5.10; c. elegans.
DR CTD; 174352; -.
DR WormBase; F22B5.10; CE02196; WBGene00009045; -.
DR eggNOG; KOG3312; Eukaryota.
DR GeneTree; ENSGT00390000002659; -.
DR HOGENOM; CLU_081121_0_0_1; -.
DR InParanoid; Q19714; -.
DR OMA; WADTLLI; -.
DR OrthoDB; 1506634at2759; -.
DR PhylomeDB; Q19714; -.
DR PRO; PR:Q19714; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00009045; Expressed in embryo and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; HDA:WormBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IDA:UniProtKB.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IDA:UniProtKB.
DR InterPro; IPR002809; EMC3/TMCO1.
DR InterPro; IPR008559; TMCO1.
DR PANTHER; PTHR20917; PTHR20917; 1.
DR Pfam; PF01956; EMC3_TMCO1; 1.
DR PIRSF; PIRSF023322; DUF841_euk; 1.
DR SMART; SM01415; DUF106; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium channel; Calcium transport; Coiled coil;
KW Endoplasmic reticulum; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..186
FT /note="Calcium load-activated calcium channel homolog"
FT /id="PRO_0000437216"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9UM00"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..87
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q9UM00"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9UM00"
FT INTRAMEM 135..151
FT /note="Pore-forming"
FT /evidence="ECO:0000250|UniProtKB:Q9UM00"
FT TOPO_DOM 152..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9UM00"
FT COILED 30..86
FT /evidence="ECO:0000255"
SQ SEQUENCE 186 AA; 21299 MW; 7CC420744A53E8C2 CRC64;
MLGDCLLIIA IAFGTALAGE GITWLLVYRS DHYKRLKADM DKKTKKLEKK KQEVGDTNDK
NIKRKLEREE ERLKATNRDM SMFKMKSMFA IGLAFTALLS TFNSIFEGRV VAKLPFYPIG
FIQGLSHRNL IGEDMTDCSF IFLYILCTMT VRQNLQKILG FAPSRAMARQ QSSPWAPPNS
QMNYLR
