ID   TMCO2_HUMAN             Reviewed;         182 AA.
AC   Q7Z6W1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transmembrane and coiled-coil domain-containing protein 2;
GN   Name=TMCO2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q7Z6W1; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-12807858, EBI-745535;
CC       Q7Z6W1; Q96AL5: PBX3; NbExp=3; IntAct=EBI-12807858, EBI-741171;
CC       Q7Z6W1; P43378: PTPN9; NbExp=3; IntAct=EBI-12807858, EBI-742898;
CC       Q7Z6W1; O00560: SDCBP; NbExp=3; IntAct=EBI-12807858, EBI-727004;
CC       Q7Z6W1; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-12807858, EBI-11955057;
CC       Q7Z6W1; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-12807858, EBI-7353612;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL050341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC108666; AAI08667.1; -; mRNA.
DR   CCDS; CCDS30684.1; -.
DR   RefSeq; NP_001008740.1; NM_001008740.3.
DR   AlphaFoldDB; Q7Z6W1; -.
DR   SMR; Q7Z6W1; -.
DR   BioGRID; 126055; 7.
DR   IntAct; Q7Z6W1; 6.
DR   STRING; 9606.ENSP00000361852; -.
DR   iPTMnet; Q7Z6W1; -.
DR   PhosphoSitePlus; Q7Z6W1; -.
DR   BioMuta; TMCO2; -.
DR   DMDM; 74750201; -.
DR   MassIVE; Q7Z6W1; -.
DR   PaxDb; Q7Z6W1; -.
DR   PeptideAtlas; Q7Z6W1; -.
DR   PRIDE; Q7Z6W1; -.
DR   ProteomicsDB; 69468; -.
DR   Antibodypedia; 76837; 7 antibodies from 5 providers.
DR   DNASU; 127391; -.
DR   Ensembl; ENST00000372766.4; ENSP00000361852.3; ENSG00000188800.6.
DR   GeneID; 127391; -.
DR   KEGG; hsa:127391; -.
DR   MANE-Select; ENST00000372766.4; ENSP00000361852.3; NM_001008740.4; NP_001008740.1.
DR   UCSC; uc001cfe.3; human.
DR   CTD; 127391; -.
DR   GeneCards; TMCO2; -.
DR   HGNC; HGNC:23312; TMCO2.
DR   HPA; ENSG00000188800; Tissue enriched (testis).
DR   neXtProt; NX_Q7Z6W1; -.
DR   OpenTargets; ENSG00000188800; -.
DR   PharmGKB; PA142670793; -.
DR   VEuPathDB; HostDB:ENSG00000188800; -.
DR   eggNOG; ENOG502RR64; Eukaryota.
DR   GeneTree; ENSGT00390000001528; -.
DR   HOGENOM; CLU_1598229_0_0_1; -.
DR   InParanoid; Q7Z6W1; -.
DR   OMA; WNWLQAT; -.
DR   OrthoDB; 1551363at2759; -.
DR   PhylomeDB; Q7Z6W1; -.
DR   TreeFam; TF337575; -.
DR   PathwayCommons; Q7Z6W1; -.
DR   SignaLink; Q7Z6W1; -.
DR   BioGRID-ORCS; 127391; 10 hits in 1065 CRISPR screens.
DR   ChiTaRS; TMCO2; human.
DR   GenomeRNAi; 127391; -.
DR   Pharos; Q7Z6W1; Tdark.
DR   PRO; PR:Q7Z6W1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q7Z6W1; protein.
DR   Bgee; ENSG00000188800; Expressed in sperm and 98 other tissues.
DR   ExpressionAtlas; Q7Z6W1; baseline and differential.
DR   Genevisible; Q7Z6W1; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   InterPro; IPR031697; TMCCDC2.
DR   PANTHER; PTHR38496; PTHR38496; 1.
DR   Pfam; PF15844; TMCCDC2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..182
FT                   /note="Transmembrane and coiled-coil domain-containing
FT                   protein 2"
FT                   /id="PRO_0000249435"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          124..151
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   182 AA;  20071 MW;  CA0A64E52CBF8462 CRC64;
     MSTSSSSSWD NLLESLSLST VWNWIQASFL GETSAPQQTS LGLLDNLAPA VQIILRISFL
     ILLGIGIYAL WKRSIQSIQK TLLFVITLYK LYKKGSHIFE ALLANPEGSG LRIQDNNNLF
     LSLGLQEKIL KKLKTVENKM KNLEGIIVAQ KPATKRDCSS EPYCSCSDCQ SPLSTSGFTS
     PI