TMCO4_MOUSE
ID TMCO4_MOUSE Reviewed; 631 AA.
AC Q91WU4; Q8BIX8; Q9D675;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transmembrane and coiled-coil domain-containing protein 4;
GN Name=Tmco4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91WU4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91WU4-2; Sequence=VSP_028243, VSP_028244, VSP_028245;
CC -!- SIMILARITY: Belongs to the TMCO4 family. {ECO:0000305}.
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DR EMBL; AK014571; BAB29436.1; -; mRNA.
DR EMBL; AK029092; BAC26291.1; -; mRNA.
DR EMBL; AK054337; BAC35737.1; -; mRNA.
DR EMBL; AK170619; BAE41914.1; -; mRNA.
DR EMBL; AK171189; BAE42299.1; -; mRNA.
DR EMBL; AL805923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013471; AAH13471.1; -; mRNA.
DR CCDS; CCDS18837.1; -. [Q91WU4-1]
DR RefSeq; NP_001292352.1; NM_001305423.1. [Q91WU4-1]
DR RefSeq; NP_084133.1; NM_029857.3. [Q91WU4-1]
DR RefSeq; XP_006539343.1; XM_006539280.3. [Q91WU4-1]
DR AlphaFoldDB; Q91WU4; -.
DR STRING; 10090.ENSMUSP00000059320; -.
DR ESTHER; mouse-tmco4; Duf_726.
DR iPTMnet; Q91WU4; -.
DR PhosphoSitePlus; Q91WU4; -.
DR EPD; Q91WU4; -.
DR MaxQB; Q91WU4; -.
DR PaxDb; Q91WU4; -.
DR PRIDE; Q91WU4; -.
DR ProteomicsDB; 259572; -. [Q91WU4-1]
DR ProteomicsDB; 259573; -. [Q91WU4-2]
DR Antibodypedia; 3034; 78 antibodies from 15 providers.
DR DNASU; 77056; -.
DR Ensembl; ENSMUST00000043042; ENSMUSP00000041388; ENSMUSG00000041143. [Q91WU4-1]
DR Ensembl; ENSMUST00000050949; ENSMUSP00000059320; ENSMUSG00000041143. [Q91WU4-1]
DR GeneID; 77056; -.
DR KEGG; mmu:77056; -.
DR UCSC; uc008vlp.2; mouse. [Q91WU4-1]
DR CTD; 255104; -.
DR MGI; MGI:1924306; Tmco4.
DR VEuPathDB; HostDB:ENSMUSG00000041143; -.
DR eggNOG; KOG2385; Eukaryota.
DR GeneTree; ENSGT00390000001400; -.
DR HOGENOM; CLU_016865_0_1_1; -.
DR InParanoid; Q91WU4; -.
DR OMA; EHISWSW; -.
DR OrthoDB; 1281288at2759; -.
DR PhylomeDB; Q91WU4; -.
DR TreeFam; TF312951; -.
DR BioGRID-ORCS; 77056; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q91WU4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q91WU4; protein.
DR Bgee; ENSMUSG00000041143; Expressed in urinary bladder urothelium and 92 other tissues.
DR ExpressionAtlas; Q91WU4; baseline and differential.
DR Genevisible; Q91WU4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920; PTHR17920; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..631
FT /note="Transmembrane and coiled-coil domain-containing
FT protein 4"
FT /id="PRO_0000305150"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 156..183
FT /evidence="ECO:0000255"
FT COMPBIAS 555..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 191..246
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028243"
FT VAR_SEQ 419..421
FT /note="DCQ -> VSG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028244"
FT VAR_SEQ 422..631
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028245"
FT CONFLICT 81
FT /note="I -> M (in Ref. 3; AAH13471)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="A -> T (in Ref. 3; AAH13471)"
FT /evidence="ECO:0000305"
FT CONFLICT 524
FT /note="R -> G (in Ref. 3; AAH13471)"
FT /evidence="ECO:0000305"
FT CONFLICT 551
FT /note="I -> T (in Ref. 3; AAH13471)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 631 AA; 67945 MW; F00E35C1CB7EDE27 CRC64;
MATWNRPHPR QPVAPEPAAE DDSQQPLGRE LSEANRFAYA ALCGFSLSQL FPEPEQSSFC
TEFVTGLVKW LHLSESVLPT IMAFASGLGG EGADIFAQTL LQDPILRDNP SAVSQDLLSF
SLKNGHYDAR ARVLVCHVTS LLQVPMEELD ILEEVFLESL KDAKEEESET AEASRKRKEK
RRKWKRYLLI GLATVGGGTV IGVTGGLAAP LVAAGAATII GSAGAAALGS VAGIAVMTSL
FGAAGAGLTG YKMKKRVGAI EEFMFLPLTE GRQLHITIAI TGWLGSGRYR TFNAPWMALA
RSQEQYCLAW EAKYLMELGN ALETILSGLA NMVAQEALKY TVLSGIVAAL TWPASLLSVA
NVIDNPWGVC LHRSAEVGKH LAHILLSRQQ GRRPVTLIGF SLGARVIYFC LQEMAQEQDC
QGIIEDVVLL GAPVEGDPKH WEPFRNVVSG RIINGYCRGD WLLSFVYRTS SVQLRVAGLQ
PVLLQDRRME NVDLTSVVNG HLDYAKQMDA ILKVVGIRTK PGWREKGLPL APGSLPQEEP
LQTAIVSTDE IILQDGQSQG PASEDSLKTT IPSSASQAQM PAGLNQSTED SLSTAAAPAE
GHLICSHGVG PNPLGCPDCT HGTQESCTEL D
