ID   TMCO4_RAT               Reviewed;         631 AA.
AC   Q499U8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Transmembrane and coiled-coil domain-containing protein 4;
GN   Name=Tmco4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMCO4 family. {ECO:0000305}.
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DR   EMBL; BC099755; AAH99755.1; -; mRNA.
DR   RefSeq; NP_001030121.1; NM_001034949.1.
DR   AlphaFoldDB; Q499U8; -.
DR   STRING; 10116.ENSRNOP00000023431; -.
DR   ESTHER; rat-tmco4; Duf_726.
DR   PhosphoSitePlus; Q499U8; -.
DR   PaxDb; Q499U8; -.
DR   PRIDE; Q499U8; -.
DR   GeneID; 500573; -.
DR   KEGG; rno:500573; -.
DR   UCSC; RGD:1566357; rat.
DR   CTD; 255104; -.
DR   RGD; 1566357; Tmco4.
DR   eggNOG; KOG2385; Eukaryota.
DR   InParanoid; Q499U8; -.
DR   PhylomeDB; Q499U8; -.
DR   PRO; PR:Q499U8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007941; DUF726.
DR   PANTHER; PTHR17920; PTHR17920; 1.
DR   Pfam; PF05277; DUF726; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..631
FT                   /note="Transmembrane and coiled-coil domain-containing
FT                   protein 4"
FT                   /id="PRO_0000305151"
FT   TRANSMEM        187..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          153..183
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        569..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  67795 MW;  CF929026B2188426 CRC64;
     MATWNRPHPR LPVAPEPVAE GESQQPLGRE LSEANRFAYA ALCGISLSQL FPEPEQSSFC
     SEFVTGLVKW LHLSETVLPT MMAFASGLGG KGDDIFAQTL LKDPILKDNP SAISQDLLSF
     SLKDGHYDAR ARVLVCHVIS LLQVPMEELD ILEEVFLESL KDAKEEESET AEESRKRKEK
     RRKWKRYLLI GLATVGGGTV IGVTGGLAAP LVAAGAATII GSAGAAALGS VAGIAVMTSL
     FGAAGAGLTG YKMKKRVGAI EEFMFLPLTD GKQLHITIAI TGWLGSGRYR TFNAPWMALA
     RSQEQYCLAW EAKYLMELGN ALETILSGLA NMVAQEALKY TVLSGIVAAL TLPASLLSVA
     NVIDNPWGVC LHRSAEVGKH LAHILLSRQQ GRRPVTLIGF SLGARVIYFC LQEMAQEQDC
     QGIIEDVVLL GAPVEGDPKY WEPFRNVVSG RIINGYCRGD WLLSFVYRTS SVQLRVAGLQ
     PVLLQDRRME NVDLSSVVNG HLDYAKKMDV ILKAVGIRTK PGWSEKGLPL APGGLPQEEP
     LQPATVSTDE TIHQDEQKQG PAPGDSLKSA IPSSASQAQV PAGLDQSTED SLPAAAAPAE
     GHLVCSHGVG PNPLGCPDCT RETQESCAEL D