TMCO6_HUMAN
ID TMCO6_HUMAN Reviewed; 493 AA.
AC Q96DC7; Q9BUU0; Q9P198;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Transmembrane and coiled-coil domain-containing protein 6;
GN Name=TMCO6; ORFNames=PRO1580;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 223-493 (ISOFORM 1), AND VARIANT SER-299.
RC TISSUE=Lung, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-493.
RC TISSUE=Fetal liver;
RA Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.;
RT "Functional prediction of the coding sequences of 79 new genes deduced by
RT analysis of cDNA clones from human fetal liver.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q96DC7; Q9UMX0: UBQLN1; NbExp=7; IntAct=EBI-746174, EBI-741480;
CC Q96DC7; Q8NB15: ZNF511; NbExp=6; IntAct=EBI-746174, EBI-10269136;
CC Q96DC7-2; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10284552, EBI-741480;
CC Q96DC7-2; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-10284552, EBI-10173939;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96DC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96DC7-2; Sequence=VSP_028249;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
CC Sequence=AAH01910.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH09618.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=EAW62034.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK097088; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471062; EAW62034.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC001910; AAH01910.1; ALT_INIT; mRNA.
DR EMBL; BC009618; AAH09618.1; ALT_INIT; mRNA.
DR EMBL; AF119848; AAF69602.1; ALT_SEQ; mRNA.
DR CCDS; CCDS4233.2; -. [Q96DC7-1]
DR CCDS; CCDS75320.1; -. [Q96DC7-2]
DR RefSeq; NP_001287909.1; NM_001300980.1. [Q96DC7-2]
DR RefSeq; NP_001287911.1; NM_001300982.1.
DR RefSeq; NP_060972.3; NM_018502.4. [Q96DC7-1]
DR RefSeq; XP_011535970.1; XM_011537668.2.
DR RefSeq; XP_016865109.1; XM_017009620.1.
DR AlphaFoldDB; Q96DC7; -.
DR SMR; Q96DC7; -.
DR BioGRID; 120647; 13.
DR IntAct; Q96DC7; 6.
DR STRING; 9606.ENSP00000252100; -.
DR iPTMnet; Q96DC7; -.
DR PhosphoSitePlus; Q96DC7; -.
DR BioMuta; TMCO6; -.
DR DMDM; 158706351; -.
DR EPD; Q96DC7; -.
DR jPOST; Q96DC7; -.
DR MassIVE; Q96DC7; -.
DR MaxQB; Q96DC7; -.
DR PaxDb; Q96DC7; -.
DR PeptideAtlas; Q96DC7; -.
DR PRIDE; Q96DC7; -.
DR Antibodypedia; 45459; 62 antibodies from 19 providers.
DR DNASU; 55374; -.
DR Ensembl; ENST00000252100.6; ENSP00000252100.6; ENSG00000113119.13. [Q96DC7-2]
DR Ensembl; ENST00000394671.8; ENSP00000378166.3; ENSG00000113119.13. [Q96DC7-1]
DR GeneID; 55374; -.
DR KEGG; hsa:55374; -.
DR MANE-Select; ENST00000394671.8; ENSP00000378166.3; NM_018502.5; NP_060972.3.
DR UCSC; uc003lgl.4; human. [Q96DC7-1]
DR CTD; 55374; -.
DR DisGeNET; 55374; -.
DR GeneCards; TMCO6; -.
DR HGNC; HGNC:28814; TMCO6.
DR HPA; ENSG00000113119; Low tissue specificity.
DR MalaCards; TMCO6; -.
DR neXtProt; NX_Q96DC7; -.
DR OpenTargets; ENSG00000113119; -.
DR PharmGKB; PA162405810; -.
DR VEuPathDB; HostDB:ENSG00000113119; -.
DR eggNOG; ENOG502QPMC; Eukaryota.
DR GeneTree; ENSGT00390000008104; -.
DR HOGENOM; CLU_043630_0_0_1; -.
DR InParanoid; Q96DC7; -.
DR OMA; TLGNICP; -.
DR OrthoDB; 1401503at2759; -.
DR PhylomeDB; Q96DC7; -.
DR TreeFam; TF331378; -.
DR PathwayCommons; Q96DC7; -.
DR SignaLink; Q96DC7; -.
DR BioGRID-ORCS; 55374; 69 hits in 1083 CRISPR screens.
DR ChiTaRS; TMCO6; human.
DR GenomeRNAi; 55374; -.
DR Pharos; Q96DC7; Tdark.
DR PRO; PR:Q96DC7; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96DC7; protein.
DR Bgee; ENSG00000113119; Expressed in sural nerve and 131 other tissues.
DR ExpressionAtlas; Q96DC7; baseline and differential.
DR Genevisible; Q96DC7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR SMART; SM00185; ARM; 5.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..493
FT /note="Transmembrane and coiled-coil domain-containing
FT protein 6"
FT /id="PRO_0000305157"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 15..84
FT /evidence="ECO:0000255"
FT VAR_SEQ 230
FT /note="P -> PPASASS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028249"
FT VARIANT 299
FT /note="T -> S (in dbSNP:rs17208187)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035171"
FT CONFLICT 442
FT /note="Q -> R (in Ref. 4; AAF69602)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 493 AA; 54442 MW; 0B50C721866613B2 CRC64;
MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP EEAGEGCVAA
ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ QTFIRLEGSM RTLVGLLTSN
QALLQLEAAR CLHELSHSEQ STVAEACLPA TSYLLTYLSS HSSDFIELCL YTLGNLIVES
EAVRRQLLPQ GIVPALAACI QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH
MLQMLQPGPK LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE
DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF QKQPSLLPEG
LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM VLTVLCNVAE KGPAYCQRLW
PGPLLPALLH TLAFSDTEVV GQSLELLHLL FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ
DRVYALQQTA LQG
