TMCO6_MOUSE
ID TMCO6_MOUSE Reviewed; 494 AA.
AC Q8BQX5; Q99JV8; Q9CWP3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane and coiled-coil domain-containing protein 6;
GN Name=Tmco6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Embryonic stem cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BQX5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BQX5-2; Sequence=VSP_059937, VSP_059938;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26978.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC32636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AK010487; BAB26978.1; ALT_FRAME; mRNA.
DR EMBL; AK046207; BAC32636.1; ALT_SEQ; mRNA.
DR EMBL; BC005637; AAH05637.2; -; mRNA.
DR CCDS; CCDS37772.1; -. [Q8BQX5-1]
DR RefSeq; NP_082312.3; NM_028036.3. [Q8BQX5-1]
DR AlphaFoldDB; Q8BQX5; -.
DR SMR; Q8BQX5; -.
DR STRING; 10090.ENSMUSP00000007046; -.
DR PhosphoSitePlus; Q8BQX5; -.
DR EPD; Q8BQX5; -.
DR MaxQB; Q8BQX5; -.
DR PaxDb; Q8BQX5; -.
DR PRIDE; Q8BQX5; -.
DR ProteomicsDB; 259250; -. [Q8BQX5-1]
DR ProteomicsDB; 259251; -. [Q8BQX5-2]
DR Antibodypedia; 45459; 62 antibodies from 19 providers.
DR Ensembl; ENSMUST00000007046; ENSMUSP00000007046; ENSMUSG00000006850. [Q8BQX5-1]
DR Ensembl; ENSMUST00000237727; ENSMUSP00000157431; ENSMUSG00000006850. [Q8BQX5-2]
DR GeneID; 71983; -.
DR KEGG; mmu:71983; -.
DR UCSC; uc008eoh.1; mouse. [Q8BQX5-2]
DR UCSC; uc008eoi.1; mouse. [Q8BQX5-1]
DR CTD; 55374; -.
DR MGI; MGI:1919233; Tmco6.
DR VEuPathDB; HostDB:ENSMUSG00000006850; -.
DR eggNOG; ENOG502QPMC; Eukaryota.
DR GeneTree; ENSGT00390000008104; -.
DR HOGENOM; CLU_043630_0_0_1; -.
DR InParanoid; Q8BQX5; -.
DR OMA; TLGNICP; -.
DR OrthoDB; 1401503at2759; -.
DR PhylomeDB; Q8BQX5; -.
DR TreeFam; TF331378; -.
DR BioGRID-ORCS; 71983; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Tmco6; mouse.
DR PRO; PR:Q8BQX5; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BQX5; protein.
DR Bgee; ENSMUSG00000006850; Expressed in granulocyte and 148 other tissues.
DR ExpressionAtlas; Q8BQX5; baseline and differential.
DR Genevisible; Q8BQX5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR SMART; SM00185; ARM; 4.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..494
FT /note="Transmembrane and coiled-coil domain-containing
FT protein 6"
FT /id="PRO_0000305158"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 15..39
FT /evidence="ECO:0000255"
FT VAR_SEQ 106..128
FT /note="LEGSMRTLVGILTSNRALLQLEA -> SEAGGQHADPCWDFDQQPGLVAA
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_059937"
FT VAR_SEQ 129..494
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_059938"
FT CONFLICT 190
FT /note="Q -> R (in Ref. 1; BAB26978)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="W -> R (in Ref. 2; AAH05637)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 54915 MW; 92DE0FE3F407B981 CRC64;
MWNRRQGRLR TLAFGVEELR RRRREREAAL RKARREQQLV SKRLLREDAP EEVGGQSAAV
LLGEAEVQQF LRLAQRGTDE KEREKALVSL RRGLQHPDTQ QTFIRLEGSM RTLVGILTSN
RALLQLEAAR CLHELSHSEQ SAVAEACLPA TSYLLTYLSG HSSDFIELCL YTLGNLIVES
EAVRKQLLPQ GIVPAFAACI QSPHVAVLEA LGYALSQLLQ AKEAPEKIIP SILDSSLPQQ
MLWLMQPGPK LNLGVAMEFA WCLHYIICSQ VNNAVLLTHG ALPTLALLLL DLAGTVQRMD
DVGLELLACP VLRCLSNLLT EVPAEVMGQQ MELRDERLVA ALFIFLQFFL QKQPALLPEG
LWLLNNLTAN SPTFCTSLLS LDLIEPLLQL LPLSNAVCML VLTVLCNVVE KGPAYCQRLW
PGPLLSCVLN TLALSDTEVV GQSLELLQLL FLHQPEAARA FLQQSGLQAL EKLQEETQLQ
ERIHALQQIA ATHG
