TMD11_MOUSE
ID TMD11_MOUSE Reviewed; 215 AA.
AC Q9D2R4;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane emp24 domain-containing protein 11;
DE AltName: Full=Glycoprotein 25L;
DE Short=GP25L;
DE AltName: Full=p24 family protein alpha-1;
DE Short=p24alpha1;
DE Flags: Precursor;
GN Name=Tmed11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Part of a complex whose function is to bind Ca(2+) to the ER
CC membrane and thereby regulate the retention of ER resident proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; AK019032; BAB31517.1; -; mRNA.
DR CCDS; CCDS19519.1; -.
DR RefSeq; NP_080385.2; NM_026109.2.
DR AlphaFoldDB; Q9D2R4; -.
DR SMR; Q9D2R4; -.
DR STRING; 10090.ENSMUSP00000004943; -.
DR GlyGen; Q9D2R4; 1 site.
DR MaxQB; Q9D2R4; -.
DR PaxDb; Q9D2R4; -.
DR PRIDE; Q9D2R4; -.
DR ProteomicsDB; 259474; -.
DR DNASU; 67366; -.
DR Ensembl; ENSMUST00000004943; ENSMUSP00000004943; ENSMUSG00000004821.
DR GeneID; 67366; -.
DR KEGG; mmu:67366; -.
DR UCSC; uc008ypd.1; mouse.
DR CTD; 67366; -.
DR MGI; MGI:1914616; Tmed11.
DR VEuPathDB; HostDB:ENSMUSG00000004821; -.
DR eggNOG; KOG1690; Eukaryota.
DR GeneTree; ENSGT00940000160999; -.
DR HOGENOM; CLU_066963_2_2_1; -.
DR InParanoid; Q9D2R4; -.
DR OMA; SAAFYFH; -.
DR OrthoDB; 1294924at2759; -.
DR PhylomeDB; Q9D2R4; -.
DR TreeFam; TF314123; -.
DR BioGRID-ORCS; 67366; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q9D2R4; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D2R4; protein.
DR Bgee; ENSMUSG00000004821; Expressed in pyloric antrum and 8 other tissues.
DR ExpressionAtlas; Q9D2R4; baseline and differential.
DR Genevisible; Q9D2R4; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR015719; TMED11.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR PANTHER; PTHR22811:SF3; PTHR22811:SF3; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000250"
FT CHAIN 18..215
FT /note="Transmembrane emp24 domain-containing protein 11"
FT /id="PRO_0000010379"
FT TOPO_DOM 18..167
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..125
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT COILED 136..171
FT /evidence="ECO:0000255"
FT MOTIF 208..215
FT /note="COPI vesicle coat-binding"
FT /evidence="ECO:0000255"
FT MOTIF 208..209
FT /note="COPII vesicle coat-binding"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 215 AA; 24842 MW; 9261BE37A2C6F59C CRC64;
MQIQTILLCF SFSFSAAFYF HAGEREEKCI IEDIPSDTLI TGTFKVQQWD IVRHDFLESA
PGLGMFVTVT TYNDEVLLSK LYGAQGTFYF TSHSSGEHII CLESNSTQFV SFGGSKLRIH
LDIRVGEHDL DAAIVQAKDK VNEVTFKLQH LIEQVEQILK EQDYQRDREE NFRITSEDTN
RNVLWWAFAQ ILIFISVGIF QMKHLKDFFI AKKLV
