TMED1_BOVIN
ID TMED1_BOVIN Reviewed; 227 AA.
AC Q2TBK5;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Transmembrane emp24 domain-containing protein 1;
DE AltName: Full=p24 family protein gamma-1;
DE Short=p24gamma1;
DE Flags: Precursor;
GN Name=TMED1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential role in vesicular protein trafficking, mainly in
CC the early secretory pathway. May act as a cargo receptor at the lumenal
CC side for incorporation of secretory cargo molecules into transport
CC vesicles and may be involved in vesicle coat formation at the
CC cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6
CC production by interacting with interleukin-33 receptor IL1RL1. Plays
CC also a role in the modulation of innate immune signaling through the
CC cGAS-STING pathway by interacting with RNF26.
CC {ECO:0000250|UniProtKB:Q13445}.
CC -!- SUBUNIT: Homodimer in endoplasmic reticulum, endoplasmic reticulum-
CC Golgi intermediate compartment and cis-Golgi network. Interacts with
CC IL1RL1. Interacts with RNF26; this interaction is important to modulate
CC innate immune signaling through the cGAS-STING pathway.
CC {ECO:0000250|UniProtKB:Q13445}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13445};
CC Single-pass type I membrane protein {ECO:0000255}. Endoplasmic
CC reticulum membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane
CC protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; BC110006; AAI10007.1; -; mRNA.
DR RefSeq; NP_001033652.1; NM_001038563.2.
DR AlphaFoldDB; Q2TBK5; -.
DR SMR; Q2TBK5; -.
DR STRING; 9913.ENSBTAP00000014563; -.
DR PaxDb; Q2TBK5; -.
DR PeptideAtlas; Q2TBK5; -.
DR Ensembl; ENSBTAT00000014563; ENSBTAP00000014563; ENSBTAG00000010968.
DR GeneID; 538144; -.
DR KEGG; bta:538144; -.
DR CTD; 11018; -.
DR VEuPathDB; HostDB:ENSBTAG00000010968; -.
DR VGNC; VGNC:35934; TMED1.
DR eggNOG; KOG3287; Eukaryota.
DR GeneTree; ENSGT00940000158445; -.
DR HOGENOM; CLU_066963_0_0_1; -.
DR InParanoid; Q2TBK5; -.
DR OMA; EICFDNG; -.
DR OrthoDB; 1292519at2759; -.
DR TreeFam; TF313000; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000010968; Expressed in laryngeal cartilage and 106 other tissues.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Endoplasmic reticulum; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..227
FT /note="Transmembrane emp24 domain-containing protein 1"
FT /id="PRO_0000248018"
FT TOPO_DOM 24..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 43..125
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT COILED 145..170
FT /evidence="ECO:0000255"
FT MOTIF 218..227
FT /note="COPI vesicle coat-binding"
FT /evidence="ECO:0000255"
FT MOTIF 218..219
FT /note="COPII vesicle coat-binding"
FT /evidence="ECO:0000255"
SQ SEQUENCE 227 AA; 25138 MW; 58EC09DF683C4417 CRC64;
MMAAGTALGL ALWLLLPPVG VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY
QVIGGAGLDV DFSLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF
FELIFDSLQD EEEVEGWAEA VEPEEILEVK MEDIKESIET MRIRLERSIQ VLTLLRAFEA
RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPM
