BTBBA_DANRE
ID BTBBA_DANRE Reviewed; 1021 AA.
AC Q1LVW0; Q1MTD0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein BTBD11-A {ECO:0000250|UniProtKB:P0C7A6};
DE AltName: Full=BTB/POZ domain-containing protein 11-A;
GN Name=btbd11a; ORFNames=si:ch211-133h2.1, si:ch211-161f1.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1LVW0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1LVW0-2; Sequence=VSP_053045, VSP_053046;
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DR EMBL; AL928936; CAK04094.1; -; Genomic_DNA.
DR EMBL; BX005210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX649350; CAK04216.1; -; Genomic_DNA.
DR RefSeq; NP_001038467.1; NM_001045002.1.
DR RefSeq; NP_001314771.1; NM_001327842.1. [Q1LVW0-1]
DR RefSeq; XP_009298436.1; XM_009300161.1. [Q1LVW0-2]
DR AlphaFoldDB; Q1LVW0; -.
DR SMR; Q1LVW0; -.
DR STRING; 7955.ENSDARP00000086682; -.
DR PaxDb; Q1LVW0; -.
DR Ensembl; ENSDART00000092250; ENSDARP00000086682; ENSDARG00000063255. [Q1LVW0-1]
DR GeneID; 562893; -.
DR KEGG; dre:562893; -.
DR CTD; 562893; -.
DR ZFIN; ZDB-GENE-050419-142; btbd11a.
DR eggNOG; ENOG502QSQY; Eukaryota.
DR GeneTree; ENSGT00940000156419; -.
DR HOGENOM; CLU_001918_0_0_1; -.
DR InParanoid; Q1LVW0; -.
DR OrthoDB; 416322at2759; -.
DR PhylomeDB; Q1LVW0; -.
DR TreeFam; TF106437; -.
DR PRO; PR:Q1LVW0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000063255; Expressed in brain and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF47113; SSF47113; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ANK repeat; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1021
FT /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT BTBD11-A"
FT /id="PRO_0000367030"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 515..544
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 561..590
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 599..628
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 642..671
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT DOMAIN 836..902
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT VAR_SEQ 1..338
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_053045"
FT VAR_SEQ 339
FT /note="L -> MPIARLNSAPLNSHFWRPVWGASPSSV (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_053046"
SQ SEQUENCE 1021 AA; 113811 MW; 532FBBFEE4710A8D CRC64;
MAGKGKTAAR TLEDLTLDSG YGGAADSFRS SSVSLCCSDT HLSYAHGGNC WHLTESMHSR
HNSLDTVNTV LAEDTEILEC SGQCAKLPEL EEDVPWSLGE VEGALRKDEE LCVGNASREI
LAKLSALVSR ALVRIAREAQ RMSLRYARCT KHEIQSAIKM VLSWTISVNC ITAALSALSL
YNMSTGDKFS RGKSTRCGLI FSVGKFFRWM VDSRVALRIH EHAAIYLSAC MESLFREVFT
RVQRSALVEK ENGVPKFSVE SLEQAINNDS ELWGLLQPYQ HLICGKNASG VLSLPDSLNL
HRDQQRAGKT GEGHAYSQAE LRTIEQSLLA TRVGSIAELS DLVSRAMHHL QPLHIKNPSN
GTPVHQNRTG SVHWEPEALY TLCYFMHCPQ MEWENPNVEP SKITLHTERP FLVLPPLMEW
IRVAVAHTEH RRSFSVDSDD VRQAARLLLP GVDCEPRQLK ADDCFCATRK LDAASTEAKF
LQDLGFRMLN CGRTDLVKQA VNLLGPDGIN SMSEQGMTPL MYSCVRGDEA MVQMLLDAGA
DINSEVPSSL HKHPSVYPDT RQGTPLTFAV LHGHVPVVQL LLDARANVEG AIQESTENYT
ETPLQLASAA GNFELVSLLL ERGADPLIGT TYRNGISSGP LGEMNSYSLA AAHGHRNVFR
KLLSQVEKDK GDVLSLEEML AEGSEAVERR APQNEGTLRT GKAKLRALRE AMYHSAEHGH
VDITIDIRSL GVPWTLHTWL ESLRTCFVQQ RRPLIQGLLK DFSCIKEDEY TEELITHGLP
LMFQILRASK NEVISQQLSV IFTQCYGPFP IPKLTEIKKK QTSRLDPHFL NNKEMSDVTF
LVEGKPFYAH KVLLFTASPR FKSLLSNRPA AENTCIEISH VKYNIFQLVM QYLYCGGTES
LHIRNTEIME LLSAAKFFQL DALQRHCEII CSKNITNDSC VDIYKHARFL GALELAGFIE
GFFLKNMVLL IELENFKQLL YEVPADSPGP GPSYDVLHDL EQTLALRIRS IHLSTSKGSI
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