ID   TMED1_PONAB             Reviewed;         227 AA.
AC   Q5R7E6;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transmembrane emp24 domain-containing protein 1;
DE   AltName: Full=p24 family protein gamma-1;
DE            Short=p24gamma1;
DE   Flags: Precursor;
GN   Name=TMED1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential role in vesicular protein trafficking, mainly in
CC       the early secretory pathway. May act as a cargo receptor at the lumenal
CC       side for incorporation of secretory cargo molecules into transport
CC       vesicles and may be involved in vesicle coat formation at the
CC       cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6
CC       production by interacting with interleukin-33 receptor IL1RL1. Plays
CC       also a role in the modulation of innate immune signaling through the
CC       cGAS-STING pathway by interacting with RNF26.
CC       {ECO:0000250|UniProtKB:Q13445}.
CC   -!- SUBUNIT: Homodimer in endoplasmic reticulum, endoplasmic reticulum-
CC       Golgi intermediate compartment and cis-Golgi network. Interacts with
CC       IL1RL1. Interacts with RNF26; this interaction is important to modulate
CC       innate immune signaling through the cGAS-STING pathway.
CC       {ECO:0000250|UniProtKB:Q13445}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13445};
CC       Single-pass type I membrane protein {ECO:0000255}. Endoplasmic
CC       reticulum membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC       membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network
CC       membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane
CC       protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR   EMBL; CR860172; CAH92314.1; -; mRNA.
DR   RefSeq; NP_001126357.1; NM_001132885.1.
DR   AlphaFoldDB; Q5R7E6; -.
DR   SMR; Q5R7E6; -.
DR   STRING; 9601.ENSPPYP00000010726; -.
DR   Ensembl; ENSPPYT00000011146; ENSPPYP00000010726; ENSPPYG00000009563.
DR   GeneID; 100443715; -.
DR   KEGG; pon:100443715; -.
DR   CTD; 11018; -.
DR   eggNOG; KOG3287; Eukaryota.
DR   GeneTree; ENSGT00940000158445; -.
DR   HOGENOM; CLU_066963_0_0_1; -.
DR   InParanoid; Q5R7E6; -.
DR   OMA; EICFDNG; -.
DR   OrthoDB; 1292519at2759; -.
DR   TreeFam; TF313000; -.
DR   Proteomes; UP000001595; Chromosome 19.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR015720; Emp24-like.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   PANTHER; PTHR22811; PTHR22811; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Endoplasmic reticulum; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..227
FT                   /note="Transmembrane emp24 domain-containing protein 1"
FT                   /id="PRO_0000248021"
FT   TOPO_DOM        24..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          43..125
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT   COILED          145..170
FT                   /evidence="ECO:0000255"
FT   MOTIF           218..227
FT                   /note="COPI vesicle coat-binding"
FT                   /evidence="ECO:0000255"
FT   MOTIF           218..219
FT                   /note="COPII vesicle coat-binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   227 AA;  25134 MW;  A2F92697572B66C2 CRC64;
     MMAAGAALAL ALWLLMPPVG VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY
     QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF
     FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA
     RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT