TMED1_RAT
ID TMED1_RAT Reviewed; 227 AA.
AC Q5BK85;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transmembrane emp24 domain-containing protein 1;
DE AltName: Full=Interleukin-1 receptor-like 1 ligand;
DE AltName: Full=p24 family protein gamma-1;
DE Short=p24gamma1;
DE Flags: Precursor;
GN Name=Tmed1; Synonyms=Il1rl1l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential role in vesicular protein trafficking, mainly in
CC the early secretory pathway. May act as a cargo receptor at the lumenal
CC side for incorporation of secretory cargo molecules into transport
CC vesicles and may be involved in vesicle coat formation at the
CC cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6
CC production by interacting with interleukin-33 receptor IL1RL1. Plays
CC also a role in the modulation of innate immune signaling through the
CC cGAS-STING pathway by interacting with RNF26.
CC {ECO:0000250|UniProtKB:Q13445}.
CC -!- SUBUNIT: Homodimer in endoplasmic reticulum, endoplasmic reticulum-
CC Golgi intermediate compartment and cis-Golgi network. Interacts with
CC IL1RL1. Interacts with RNF26; this interaction is important to modulate
CC innate immune signaling through the cGAS-STING pathway.
CC {ECO:0000250|UniProtKB:Q13445}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13445};
CC Single-pass type I membrane protein {ECO:0000255}. Endoplasmic
CC reticulum membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane
CC protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; BC091167; AAH91167.1; -; mRNA.
DR RefSeq; NP_001013450.1; NM_001013432.1.
DR AlphaFoldDB; Q5BK85; -.
DR SMR; Q5BK85; -.
DR BioGRID; 261034; 1.
DR STRING; 10116.ENSRNOP00000057728; -.
DR PaxDb; Q5BK85; -.
DR Ensembl; ENSRNOT00000061009; ENSRNOP00000057728; ENSRNOG00000008037.
DR GeneID; 315461; -.
DR KEGG; rno:315461; -.
DR UCSC; RGD:1311679; rat.
DR CTD; 11018; -.
DR RGD; 1311679; Tmed1.
DR eggNOG; KOG3287; Eukaryota.
DR GeneTree; ENSGT00940000158445; -.
DR HOGENOM; CLU_066963_0_0_1; -.
DR InParanoid; Q5BK85; -.
DR OMA; EICFDNG; -.
DR OrthoDB; 1292519at2759; -.
DR PhylomeDB; Q5BK85; -.
DR TreeFam; TF313000; -.
DR PRO; PR:Q5BK85; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000008037; Expressed in quadriceps femoris and 19 other tissues.
DR Genevisible; Q5BK85; RN.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:RGD.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Endoplasmic reticulum; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..227
FT /note="Transmembrane emp24 domain-containing protein 1"
FT /id="PRO_0000248022"
FT TOPO_DOM 25..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 43..125
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT COILED 145..170
FT /evidence="ECO:0000255"
FT MOTIF 218..227
FT /note="COPI vesicle coat-binding"
FT /evidence="ECO:0000255"
FT MOTIF 218..219
FT /note="COPII vesicle coat-binding"
FT /evidence="ECO:0000255"
SQ SEQUENCE 227 AA; 25210 MW; F37FC38E4E1B4495 CRC64;
MMAAGAAVAL ALWLLLPAVG VGEAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY
QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYRLCFDNS FSTISEKLVF
FELIFDSFQD EEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA
RDRNLQEDNL ERVNFWSAAN VAVLLLVAVL QVCTLKRFFH DKCPVPT
