TMED1_XENTR
ID TMED1_XENTR Reviewed; 220 AA.
AC Q28BQ6; Q0IHR8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Transmembrane emp24 domain-containing protein 1;
DE AltName: Full=p24 family protein gamma-1;
DE Short=p24gamma1;
DE Flags: Precursor;
GN Name=tmed1; ORFNames=TNeu055d12.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential role in vesicular protein trafficking, mainly in
CC the early secretory pathway. May act as a cargo receptor at the lumenal
CC side for incorporation of secretory cargo molecules into transport
CC vesicles and may be involved in vesicle coat formation at the
CC cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6
CC production by interacting with interleukin-33 receptor IL1RL1. Plays
CC also a role in the modulation of innate immune signaling through the
CC cGAS-STING pathway by interacting with RNF26.
CC {ECO:0000250|UniProtKB:Q13445}.
CC -!- SUBUNIT: Homodimer in endoplasmic reticulum, endoplasmic reticulum-
CC Golgi intermediate compartment and cis-Golgi network. Interacts with
CC IL1RL1. Interacts with RNF26; this interaction is important to modulate
CC innate immune signaling through the cGAS-STING pathway.
CC {ECO:0000250|UniProtKB:Q13445}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13445};
CC Single-pass type I membrane protein {ECO:0000255}. Endoplasmic
CC reticulum membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network
CC membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane
CC protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; CR942696; CAJ83286.1; -; mRNA.
DR EMBL; BC123004; AAI23005.1; -; mRNA.
DR RefSeq; NP_001039263.1; NM_001045798.1.
DR AlphaFoldDB; Q28BQ6; -.
DR SMR; Q28BQ6; -.
DR STRING; 8364.ENSXETP00000022100; -.
DR PaxDb; Q28BQ6; -.
DR DNASU; 734138; -.
DR GeneID; 734138; -.
DR KEGG; xtr:734138; -.
DR CTD; 11018; -.
DR Xenbase; XB-GENE-1017173; tmed1.
DR eggNOG; KOG3287; Eukaryota.
DR HOGENOM; CLU_066963_0_1_1; -.
DR InParanoid; Q28BQ6; -.
DR OrthoDB; 1292519at2759; -.
DR PhylomeDB; Q28BQ6; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000002260; Expressed in neurula embryo and 12 other tissues.
DR ExpressionAtlas; Q28BQ6; differential.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Endoplasmic reticulum; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..220
FT /note="Transmembrane emp24 domain-containing protein 1"
FT /id="PRO_0000248023"
FT TOPO_DOM 20..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..118
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT COILED 138..164
FT /evidence="ECO:0000255"
FT MOTIF 211..220
FT /note="COPI vesicle coat-binding"
FT /evidence="ECO:0000255"
FT MOTIF 211..212
FT /note="COPII vesicle coat-binding"
FT /evidence="ECO:0000255"
SQ SEQUENCE 220 AA; 24998 MW; 4CCA7ECE94AC4731 CRC64;
MAWSSSFLFI VLPLAAAVAV QPQDTELTFL LPAGRQECFY QTTLYNGSME IEYQVIGGAG
LDVDFSVTTP SGILLIMERR RSDGVHTVEP TEAGDYMICF DNSFSTISEK LVFFELIFDN
QQGDEEPDSW ADVVEPDELL DIKLEDIKES IESVKSRLER SIQMQTVLRA FEARDRNLQD
SNLERVNFWS AINVGVLVTV AFLQVYMLKS LFDDKRKIRT
