ID   TMED6_BOVIN             Reviewed;         240 AA.
AC   Q0VCA9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Transmembrane emp24 domain-containing protein 6;
DE   AltName: Full=p24 family protein gamma-5;
DE            Short=p24gamma5;
DE   Flags: Precursor;
GN   Name=TMED6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR   EMBL; BC120264; AAI20265.1; -; mRNA.
DR   RefSeq; NP_001069456.1; NM_001075988.2.
DR   AlphaFoldDB; Q0VCA9; -.
DR   SMR; Q0VCA9; -.
DR   STRING; 9913.ENSBTAP00000010015; -.
DR   PaxDb; Q0VCA9; -.
DR   PRIDE; Q0VCA9; -.
DR   Ensembl; ENSBTAT00000010015; ENSBTAP00000010015; ENSBTAG00000007616.
DR   GeneID; 533277; -.
DR   KEGG; bta:533277; -.
DR   CTD; 146456; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007616; -.
DR   eggNOG; KOG3287; Eukaryota.
DR   GeneTree; ENSGT00390000010961; -.
DR   HOGENOM; CLU_066963_5_1_1; -.
DR   InParanoid; Q0VCA9; -.
DR   OMA; RNINDMM; -.
DR   OrthoDB; 1262544at2759; -.
DR   TreeFam; TF313000; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000007616; Expressed in caput epididymis and 103 other tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   InterPro; IPR015720; Emp24-like.
DR   InterPro; IPR009038; GOLD_dom.
DR   PANTHER; PTHR22811; PTHR22811; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..240
FT                   /note="Transmembrane emp24 domain-containing protein 6"
FT                   /id="PRO_0000283034"
FT   TOPO_DOM        22..200
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          53..138
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  27850 MW;  66F038D66E2E1872 CRC64;
     MFPLLFVAGL VVLNLVSSAR SQKTEPLSGT GDQSLFRGAD QHDFAIVIPP GGTECFWQFA
     HQTGYFYFSY EVQRTIGMSH DRHVAATAHT PQGFLIETSK NVRGQINFST HETGFYQLCL
     ANQQNRFASV QVYLNFGVFY EGPEMDHKEN ERKQLNDTLD AIEESTRKVH YNIFHMWRHY
     NFARMRKTAD FFLLQSNYNY VNWWSTAQSL VIVLSGILQL YFLKRLFNTP MTTETQKPRC