TMED6_HUMAN
ID TMED6_HUMAN Reviewed; 240 AA.
AC Q8WW62; Q6UXN5;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transmembrane emp24 domain-containing protein 6;
DE AltName: Full=p24 family protein gamma-5;
DE Short=p24gamma5;
DE Flags: Precursor;
GN Name=TMED6; ORFNames=UNQ9146/PRO34237;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; AY358268; AAQ88635.1; -; mRNA.
DR EMBL; CH471092; EAW83272.1; -; Genomic_DNA.
DR EMBL; BC020827; AAH20827.1; -; mRNA.
DR CCDS; CCDS10878.1; -.
DR RefSeq; NP_653277.2; NM_144676.3.
DR AlphaFoldDB; Q8WW62; -.
DR SMR; Q8WW62; -.
DR BioGRID; 126989; 44.
DR IntAct; Q8WW62; 34.
DR STRING; 9606.ENSP00000288025; -.
DR GlyGen; Q8WW62; 2 sites.
DR iPTMnet; Q8WW62; -.
DR PhosphoSitePlus; Q8WW62; -.
DR BioMuta; TMED6; -.
DR DMDM; 166897636; -.
DR MassIVE; Q8WW62; -.
DR PaxDb; Q8WW62; -.
DR PeptideAtlas; Q8WW62; -.
DR PRIDE; Q8WW62; -.
DR ProteomicsDB; 74867; -.
DR Antibodypedia; 2528; 88 antibodies from 17 providers.
DR DNASU; 146456; -.
DR Ensembl; ENST00000288025.4; ENSP00000288025.3; ENSG00000157315.5.
DR GeneID; 146456; -.
DR KEGG; hsa:146456; -.
DR MANE-Select; ENST00000288025.4; ENSP00000288025.3; NM_144676.4; NP_653277.2.
DR UCSC; uc002exc.3; human.
DR CTD; 146456; -.
DR DisGeNET; 146456; -.
DR GeneCards; TMED6; -.
DR HGNC; HGNC:28331; TMED6.
DR HPA; ENSG00000157315; Tissue enriched (pancreas).
DR neXtProt; NX_Q8WW62; -.
DR OpenTargets; ENSG00000157315; -.
DR PharmGKB; PA128394759; -.
DR VEuPathDB; HostDB:ENSG00000157315; -.
DR eggNOG; KOG3287; Eukaryota.
DR GeneTree; ENSGT00390000010961; -.
DR HOGENOM; CLU_066963_5_1_1; -.
DR InParanoid; Q8WW62; -.
DR OMA; RNINDMM; -.
DR OrthoDB; 1262544at2759; -.
DR PhylomeDB; Q8WW62; -.
DR TreeFam; TF313000; -.
DR PathwayCommons; Q8WW62; -.
DR SignaLink; Q8WW62; -.
DR BioGRID-ORCS; 146456; 9 hits in 1066 CRISPR screens.
DR ChiTaRS; TMED6; human.
DR GenomeRNAi; 146456; -.
DR Pharos; Q8WW62; Tdark.
DR PRO; PR:Q8WW62; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8WW62; protein.
DR Bgee; ENSG00000157315; Expressed in body of pancreas and 106 other tissues.
DR Genevisible; Q8WW62; HS.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..240
FT /note="Transmembrane emp24 domain-containing protein 6"
FT /id="PRO_0000010393"
FT TOPO_DOM 22..200
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 53..138
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 70
FT /note="Y -> C (in Ref. 3; AAH20827)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 27631 MW; E65B966E12533A83 CRC64;
MSPLLFGAGL VVLNLVTSAR SQKTEPLSGS GDQPLFRGAD RYDFAIMIPP GGTECFWQFA
HQTGYFYFSY EVQRTVGMSH DRHVAATAHN PQGFLIDTSQ GVRGQINFST QETGFYQLCL
SNQHNHFGSV QVYLNFGVFY EGPETDHKQK ERKQLNDTLD AIEDGTQKVQ NNIFHMWRYY
NFARMRKMAD FFLIQSNYNY VNWWSTAQSL VIILSGILQL YFLKRLFNVP TTTDTKKPRC
