TMED8_HUMAN
ID TMED8_HUMAN Reviewed; 325 AA.
AC Q6PL24; B3KTI6; Q3MJB0; Q9P1V9;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein TMED8;
GN Name=TMED8; Synonyms=FAM15B; ORFNames=L10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15334068; DOI=10.1038/sj.onc.1207921;
RA Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C.,
RA Cerveny C., Law C.-L., Wahl A., Carter P.;
RT "Suppression subtractive hybridization and expression profiling identifies
RT a unique set of genes overexpressed in non-small-cell lung cancer.";
RL Oncogene 23:7734-7745(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-169, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q6PL24; Q96IZ2: ADTRP; NbExp=3; IntAct=EBI-11603430, EBI-3921528;
CC Q6PL24; Q86SJ2: AMIGO2; NbExp=3; IntAct=EBI-11603430, EBI-3866830;
CC Q6PL24; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-11603430, EBI-4290634;
CC Q6PL24; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-11603430, EBI-714543;
CC Q6PL24; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-11603430, EBI-13381098;
CC Q6PL24; Q9H5X1: CIAO2A; NbExp=6; IntAct=EBI-11603430, EBI-752069;
CC Q6PL24; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-11603430, EBI-11522780;
CC Q6PL24; Q9NX76: CMTM6; NbExp=3; IntAct=EBI-11603430, EBI-1054315;
CC Q6PL24; Q8N8Q1: CYB561D1; NbExp=3; IntAct=EBI-11603430, EBI-12873482;
CC Q6PL24; Q9H1M3: DEFB129; NbExp=3; IntAct=EBI-11603430, EBI-23712762;
CC Q6PL24; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-11603430, EBI-398977;
CC Q6PL24; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-11603430, EBI-12831978;
CC Q6PL24; O14681: EI24; NbExp=3; IntAct=EBI-11603430, EBI-2339413;
CC Q6PL24; Q99525: H4C7; NbExp=3; IntAct=EBI-11603430, EBI-10294329;
CC Q6PL24; Q15012: LAPTM4A; NbExp=3; IntAct=EBI-11603430, EBI-723416;
CC Q6PL24; P21741: MDK; NbExp=3; IntAct=EBI-11603430, EBI-722444;
CC Q6PL24; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-11603430, EBI-6163737;
CC Q6PL24; Q8IXM3: MRPL41; NbExp=3; IntAct=EBI-11603430, EBI-912501;
CC Q6PL24; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-11603430, EBI-750085;
CC Q6PL24; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-11603430, EBI-3923617;
CC Q6PL24; Q9UI09: NDUFA12; NbExp=3; IntAct=EBI-11603430, EBI-1246332;
CC Q6PL24; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-11603430, EBI-14065960;
CC Q6PL24; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-11603430, EBI-749270;
CC Q6PL24; Q9UNK0: STX8; NbExp=4; IntAct=EBI-11603430, EBI-727240;
CC Q6PL24; Q96L08: SUSD3; NbExp=3; IntAct=EBI-11603430, EBI-18194029;
CC Q6PL24; Q12893: TMEM115; NbExp=3; IntAct=EBI-11603430, EBI-8633987;
CC Q6PL24; Q9BTD3: TMEM121; NbExp=3; IntAct=EBI-11603430, EBI-12155101;
CC Q6PL24; A2RU14: TMEM218; NbExp=3; IntAct=EBI-11603430, EBI-10173151;
CC Q6PL24; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-11603430, EBI-11956809;
CC Q6PL24; Q8N609: TRAM1L1; NbExp=5; IntAct=EBI-11603430, EBI-11996766;
CC Q6PL24; Q53HI1: UNC50; NbExp=3; IntAct=EBI-11603430, EBI-7601760;
CC Q6PL24; Q969W1: ZDHHC16; NbExp=3; IntAct=EBI-11603430, EBI-11572692;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF62560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY598329; AAT06740.1; -; mRNA.
DR EMBL; AK095650; BAG53098.1; -; mRNA.
DR EMBL; AC007954; AAF62560.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC101510; AAI01511.1; -; mRNA.
DR CCDS; CCDS32125.1; -.
DR RefSeq; NP_001333062.1; NM_001346133.1.
DR RefSeq; NP_001333063.1; NM_001346134.1.
DR RefSeq; NP_998766.1; NM_213601.2.
DR AlphaFoldDB; Q6PL24; -.
DR SMR; Q6PL24; -.
DR BioGRID; 129608; 69.
DR IntAct; Q6PL24; 43.
DR MINT; Q6PL24; -.
DR STRING; 9606.ENSP00000216468; -.
DR iPTMnet; Q6PL24; -.
DR MetOSite; Q6PL24; -.
DR PhosphoSitePlus; Q6PL24; -.
DR BioMuta; TMED8; -.
DR DMDM; 62287887; -.
DR EPD; Q6PL24; -.
DR jPOST; Q6PL24; -.
DR MassIVE; Q6PL24; -.
DR MaxQB; Q6PL24; -.
DR PaxDb; Q6PL24; -.
DR PeptideAtlas; Q6PL24; -.
DR PRIDE; Q6PL24; -.
DR ProteomicsDB; 67250; -.
DR Antibodypedia; 27; 92 antibodies from 19 providers.
DR DNASU; 283578; -.
DR Ensembl; ENST00000216468.8; ENSP00000216468.7; ENSG00000100580.8.
DR GeneID; 283578; -.
DR KEGG; hsa:283578; -.
DR MANE-Select; ENST00000216468.8; ENSP00000216468.7; NM_213601.3; NP_998766.1.
DR UCSC; uc001xto.2; human.
DR CTD; 283578; -.
DR GeneCards; TMED8; -.
DR HGNC; HGNC:18633; TMED8.
DR HPA; ENSG00000100580; Low tissue specificity.
DR neXtProt; NX_Q6PL24; -.
DR OpenTargets; ENSG00000100580; -.
DR PharmGKB; PA134948632; -.
DR VEuPathDB; HostDB:ENSG00000100580; -.
DR eggNOG; KOG3878; Eukaryota.
DR GeneTree; ENSGT00530000063651; -.
DR HOGENOM; CLU_053155_0_0_1; -.
DR InParanoid; Q6PL24; -.
DR OMA; LYFHVYY; -.
DR OrthoDB; 733463at2759; -.
DR PhylomeDB; Q6PL24; -.
DR TreeFam; TF321667; -.
DR PathwayCommons; Q6PL24; -.
DR SignaLink; Q6PL24; -.
DR BioGRID-ORCS; 283578; 235 hits in 1078 CRISPR screens.
DR ChiTaRS; TMED8; human.
DR GenomeRNAi; 283578; -.
DR Pharos; Q6PL24; Tdark.
DR PRO; PR:Q6PL24; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q6PL24; protein.
DR Bgee; ENSG00000100580; Expressed in endothelial cell and 190 other tissues.
DR Genevisible; Q6PL24; HS.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR Pfam; PF13897; GOLD_2; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT CHAIN 1..325
FT /note="Protein TMED8"
FT /id="PRO_0000055638"
FT DOMAIN 159..323
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..256
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 169
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT VARIANT 5
FT /note="Q -> K (in dbSNP:rs3742737)"
FT /id="VAR_049112"
SQ SEQUENCE 325 AA; 35740 MW; 5E4880F39E5145E9 CRC64;
MSDLQAAEGP GSWSPTARPG SAGGVGDCQG VEGSQAAASE NEDLENKDTS LLASATDPEP
CSSPHRPQMV SPVSKDATED LRKATGPLEA QALVKQDLLP ADQAQVLNEM AKYQVPQRSG
DIVMIQSEHT GAIDVLSADL ESADLLGDHR KVSPPLMAPP CIWTFAKVKE FKSKLGKEKN
SRLVVKRGEV VTIRVPTHPE GKRVCWEFAT DDYDIGFGVY FDWTPVTSTD ITVQVSDSSD
DEDEEEEEEE EIEEPVPAGD VERGSRSSLR GRYGEVMPVY RRDSHRDVQA GSHDYPGEGI
YLLKFDNSYS LLRNKTLYFH IYYTS
