TMED8_MOUSE
ID TMED8_MOUSE Reviewed; 326 AA.
AC Q3UHI4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein TMED8;
GN Name=Tmed8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AK147378; BAE27873.1; -; mRNA.
DR CCDS; CCDS26072.1; -.
DR RefSeq; NP_001028647.1; NM_001033475.3.
DR AlphaFoldDB; Q3UHI4; -.
DR SMR; Q3UHI4; -.
DR STRING; 10090.ENSMUSP00000043742; -.
DR iPTMnet; Q3UHI4; -.
DR PhosphoSitePlus; Q3UHI4; -.
DR EPD; Q3UHI4; -.
DR MaxQB; Q3UHI4; -.
DR PaxDb; Q3UHI4; -.
DR PRIDE; Q3UHI4; -.
DR ProteomicsDB; 262836; -.
DR Antibodypedia; 27; 92 antibodies from 19 providers.
DR Ensembl; ENSMUST00000037418; ENSMUSP00000043742; ENSMUSG00000034111.
DR GeneID; 382620; -.
DR KEGG; mmu:382620; -.
DR UCSC; uc007oin.1; mouse.
DR CTD; 283578; -.
DR MGI; MGI:1923480; Tmed8.
DR VEuPathDB; HostDB:ENSMUSG00000034111; -.
DR eggNOG; KOG3878; Eukaryota.
DR GeneTree; ENSGT00530000063651; -.
DR HOGENOM; CLU_053155_0_0_1; -.
DR InParanoid; Q3UHI4; -.
DR OMA; LYFHVYY; -.
DR OrthoDB; 733463at2759; -.
DR PhylomeDB; Q3UHI4; -.
DR TreeFam; TF321667; -.
DR BioGRID-ORCS; 382620; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tmed8; mouse.
DR PRO; PR:Q3UHI4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3UHI4; protein.
DR Bgee; ENSMUSG00000034111; Expressed in utricle of membranous labyrinth and 214 other tissues.
DR Genevisible; Q3UHI4; MM.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR Pfam; PF13897; GOLD_2; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Reference proteome.
FT CHAIN 1..326
FT /note="Protein TMED8"
FT /id="PRO_0000322983"
FT DOMAIN 160..324
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..257
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 170
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6PL24"
SQ SEQUENCE 326 AA; 35785 MW; 712F0A3FF92FBE3F CRC64;
MSDRQAAEGP AFWSPAARRG SAGGVGDRRG VEESQAAASE KEDLESTNVS SPLASASDPA
AESSPYRPQM VSPASKDTTE DLQNVAGASE GQAPGEQAAL PAGQTQVLSE MAKYQAPQRP
EDTVMIQSEH TGAIDVLSAD LESADLLGDH RKVSPPLMAP PCVWTFAKVK EFKSKLGKEK
NSRLVVKRGE VVTIRVPTHP EGKRVCWEFA TDDYDIGFGV YFDWTPVTST DITVQVSDSS
EDEEEEEDEE EEIEEPVPVG DVERGSRSSL RGRYGEVMPV YRRDSHRDVQ AGSHDYPGEG
IYLLKFDNSY SLLRNKTLYF HIYYTS
