TMEDA_DEBHA
ID TMEDA_DEBHA Reviewed; 214 AA.
AC Q6BTC2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Endoplasmic reticulum vesicle protein 25;
DE Flags: Precursor;
GN Name=ERV25; OrderedLocusNames=DEHA2D01826g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Constituent of COPII-coated endoplasmic reticulum-derived
CC transport vesicles. Required for efficient transport of a subset of
CC secretory proteins to the Golgi. Facilitates retrograde transport from
CC the Golgi to the endoplasmic reticulum (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus
CC membrane {ECO:0000250}; Single-pass type I membrane protein
CC {ECO:0000250}. Note=Recycles between endoplasmic reticulum and Golgi.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; CR382136; CAG86680.2; -; Genomic_DNA.
DR RefSeq; XP_458548.2; XM_458548.1.
DR AlphaFoldDB; Q6BTC2; -.
DR SMR; Q6BTC2; -.
DR STRING; 4959.XP_458548.2; -.
DR EnsemblFungi; CAG86680; CAG86680; DEHA2D01826g.
DR GeneID; 2901206; -.
DR KEGG; dha:DEHA2D01826g; -.
DR VEuPathDB; FungiDB:DEHA2D01826g; -.
DR eggNOG; KOG1691; Eukaryota.
DR HOGENOM; CLU_066963_3_0_1; -.
DR InParanoid; Q6BTC2; -.
DR OMA; AMGNDYH; -.
DR OrthoDB; 1370889at2759; -.
DR Proteomes; UP000000599; Chromosome D.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..214
FT /note="Endoplasmic reticulum vesicle protein 25"
FT /id="PRO_0000237692"
FT TOPO_DOM 21..183
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 33..124
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ SEQUENCE 214 AA; 24447 MW; 2B6C4554A251C479 CRC64;
MRSISTLLFI ISTFISLVSA LQLAIPATTN PDPFCIRDFV QEEQMVVVNI KTNGNSGDGQ
RLDLRIVDSL GNEYRRKNDI AGSVKIGFTS HNSAAFDICF TNQLERKWSK NTNFVREIEL
DVESGAAARD WNAVQAAEKL KPVEVDLRRI EETTYEISGE LQYLKAREER MRDTNESTNS
RVKWFSILVI TSLVGLGAWQ VQYLRHYFKV KHII
