TMEDA_DICDI
ID TMEDA_DICDI Reviewed; 205 AA.
AC Q769F9; Q54JH1;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Transmembrane emp24 domain-containing protein A;
DE Flags: Precursor;
GN Name=empA; ORFNames=DDB_G0288053;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX4;
RA Morio T., Kuwabara Y., Sawayama M., Kuwayama H., Kawabae Y., Tanaka Y.;
RT "Regulation of development by Ddp24 genes, a family of genes involved in
RT COPI/II-coated vesicle trafficking.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Could have a role in the budding of coatomer-coated and other
CC species of coated vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; AB112541; BAD05160.1; -; Genomic_DNA.
DR EMBL; AAFI02000107; EAL63452.1; -; Genomic_DNA.
DR RefSeq; XP_636960.1; XM_631868.1.
DR AlphaFoldDB; Q769F9; -.
DR SMR; Q769F9; -.
DR STRING; 44689.DDB0201636; -.
DR PaxDb; Q769F9; -.
DR EnsemblProtists; EAL63452; EAL63452; DDB_G0288053.
DR GeneID; 8626435; -.
DR KEGG; ddi:DDB_G0288053; -.
DR dictyBase; DDB_G0288053; empA.
DR eggNOG; KOG1692; Eukaryota.
DR HOGENOM; CLU_066963_4_1_1; -.
DR InParanoid; Q769F9; -.
DR OMA; WNLFVIG; -.
DR PhylomeDB; Q769F9; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q769F9; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Membrane; Protein transport; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..205
FT /note="Transmembrane emp24 domain-containing protein A"
FT /id="PRO_0000342022"
FT TOPO_DOM 25..172
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..116
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ SEQUENCE 205 AA; 23297 MW; 3864D18CDE76FD32 CRC64;
MMNNKLLLLV IALLCIASNS IVESFSFKVS AKVEECIYEE IGVDLSFTAM FQVIQGGFND
IDFTIISPDK RIVYSGQRES EGTKTLRSSF AGVYSFCFSN KMSSLTDKTV SFILSVGESS
PIREIAKKKD LTPIERSIMT LSDGVIAVKN EQNYFKMREA AHRNTAESTN SRVLWWSVFE
AFVLIALSIW QIYYLRRFFE VKRAV
