TMEDA_DROME
ID TMEDA_DROME Reviewed; 206 AA.
AC Q8SXY6; A0AQ60; A0AQ63; A0AQ65; C0MKQ9; Q9VBZ4;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane emp24 domain-containing protein bai {ECO:0000303|PubMed:15327786, ECO:0000312|FlyBase:FBgn0045866};
DE AltName: Full=Protein baiser {ECO:0000312|EMBL:AAF56382.2};
DE Flags: Precursor;
GN Name=bai; ORFNames=CG11785;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAL26785.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-14; THR-95 AND VAL-106.
RC STRAIN=ZBMEL131 {ECO:0000312|EMBL:CAL26787.1},
RC ZBMEL157 {ECO:0000312|EMBL:CAL26788.1},
RC ZBMEL186 {ECO:0000312|EMBL:CAL26789.1},
RC ZBMEL191 {ECO:0000312|EMBL:CAL26790.1},
RC ZBMEL229 {ECO:0000312|EMBL:CAL26791.1},
RC ZBMEL377 {ECO:0000312|EMBL:CAL26792.1},
RC ZBMEL384 {ECO:0000312|EMBL:CAL26793.1},
RC ZBMEL398 {ECO:0000312|EMBL:CAL26794.1},
RC ZBMEL82 {ECO:0000312|EMBL:CAL26784.1},
RC ZBMEL84 {ECO:0000312|EMBL:CAL26785.1}, and
RC ZBMEL95 {ECO:0000312|EMBL:CAL26786.1};
RX PubMed=16951084; DOI=10.1534/genetics.106.058008;
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 174:893-900(2006).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAR93849.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-60 AND VAL-106.
RC STRAIN=MEL01 {ECO:0000312|EMBL:CAR93849.1},
RC MEL02 {ECO:0000312|EMBL:CAR93850.1}, MEL11 {ECO:0000312|EMBL:CAR93851.1},
RC MEL12 {ECO:0000312|EMBL:CAR93852.1}, MEL14 {ECO:0000312|EMBL:CAR93853.1},
RC MEL15 {ECO:0000312|EMBL:CAR93854.1}, MEL16 {ECO:0000312|EMBL:CAR93855.1},
RC MEL17 {ECO:0000312|EMBL:CAR93856.1}, MEL18 {ECO:0000312|EMBL:CAR93857.1},
RC MEL19 {ECO:0000312|EMBL:CAR93858.1}, and
RC MEL20 {ECO:0000312|EMBL:CAR93859.1};
RX PubMed=19126864; DOI=10.1093/molbev/msn297;
RA Parsch J., Zhang Z., Baines J.F.;
RT "The influence of demography and weak selection on the McDonald-Kreitman
RT test: an empirical study in Drosophila.";
RL Mol. Biol. Evol. 26:691-698(2009).
RN [3] {ECO:0000312|EMBL:AAF56382.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAF56382.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5] {ECO:0000312|EMBL:AAL68312.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL68312.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=15327786; DOI=10.1016/j.mod.2004.05.006;
RA Bartoszewski S., Luschnig S., Desjeux I., Grosshans J.,
RA Nusslein-Volhard C.;
RT "Drosophila p24 homologues eclair and baiser are necessary for the activity
RT of the maternally expressed Tkv receptor during early embryogenesis.";
RL Mech. Dev. 121:1259-1273(2004).
CC -!- FUNCTION: Eca and bai are essential, though not redundant, for
CC dorsoventral patterning of the embryo. Specifically required during
CC early embryogenesis for the activity of maternal tkv, while the zygotic
CC tkv is not affected. {ECO:0000269|PubMed:15327786}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250, ECO:0000312|FlyBase:FBgn0045866}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:15327786}.
CC -!- DISRUPTION PHENOTYPE: Mutant embryos exhibit reduced dpp signaling
CC during early embryogenesis. Maternal tkv is not active and is not
CC secreted. {ECO:0000269|PubMed:15327786}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000312|FlyBase:FBgn0045866}.
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DR EMBL; AM294798; CAL26784.1; -; Genomic_DNA.
DR EMBL; AM294799; CAL26785.1; -; Genomic_DNA.
DR EMBL; AM294800; CAL26786.1; -; Genomic_DNA.
DR EMBL; AM294801; CAL26787.1; -; Genomic_DNA.
DR EMBL; AM294802; CAL26788.1; -; Genomic_DNA.
DR EMBL; AM294803; CAL26789.1; -; Genomic_DNA.
DR EMBL; AM294804; CAL26790.1; -; Genomic_DNA.
DR EMBL; AM294805; CAL26791.1; -; Genomic_DNA.
DR EMBL; AM294806; CAL26792.1; -; Genomic_DNA.
DR EMBL; AM294807; CAL26793.1; -; Genomic_DNA.
DR EMBL; AM294808; CAL26794.1; -; Genomic_DNA.
DR EMBL; FM245923; CAR93849.1; -; Genomic_DNA.
DR EMBL; FM245924; CAR93850.1; -; Genomic_DNA.
DR EMBL; FM245925; CAR93851.1; -; Genomic_DNA.
DR EMBL; FM245926; CAR93852.1; -; Genomic_DNA.
DR EMBL; FM245927; CAR93853.1; -; Genomic_DNA.
DR EMBL; FM245928; CAR93854.1; -; Genomic_DNA.
DR EMBL; FM245929; CAR93855.1; -; Genomic_DNA.
DR EMBL; FM245930; CAR93856.1; -; Genomic_DNA.
DR EMBL; FM245931; CAR93857.1; -; Genomic_DNA.
DR EMBL; FM245932; CAR93858.1; -; Genomic_DNA.
DR EMBL; FM245933; CAR93859.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56382.2; -; Genomic_DNA.
DR EMBL; AY075503; AAL68312.1; -; mRNA.
DR RefSeq; NP_651323.3; NM_143066.3.
DR AlphaFoldDB; Q8SXY6; -.
DR SMR; Q8SXY6; -.
DR BioGRID; 67917; 6.
DR STRING; 7227.FBpp0084133; -.
DR TCDB; 9.B.188.1.6; the transmembrane emp24 domain-containing protein (tmed) family.
DR PaxDb; Q8SXY6; -.
DR PRIDE; Q8SXY6; -.
DR DNASU; 42996; -.
DR EnsemblMetazoa; FBtr0084758; FBpp0084133; FBgn0045866.
DR GeneID; 42996; -.
DR KEGG; dme:Dmel_CG11785; -.
DR UCSC; CG11785-RA; d. melanogaster.
DR CTD; 42996; -.
DR FlyBase; FBgn0045866; bai.
DR VEuPathDB; VectorBase:FBgn0045866; -.
DR eggNOG; KOG1691; Eukaryota.
DR GeneTree; ENSGT00550000074954; -.
DR HOGENOM; CLU_066963_3_1_1; -.
DR InParanoid; Q8SXY6; -.
DR OMA; AMGNDYH; -.
DR OrthoDB; 1370889at2759; -.
DR PhylomeDB; Q8SXY6; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 42996; 0 hits in 1 CRISPR screen.
DR ChiTaRS; bai; fly.
DR GenomeRNAi; 42996; -.
DR PRO; PR:Q8SXY6; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0045866; Expressed in spermathecum and 38 other tissues.
DR Genevisible; Q8SXY6; DM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR GO; GO:0038024; F:cargo receptor activity; IPI:FlyBase.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0048193; P:Golgi vesicle transport; ISM:FlyBase.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0007311; P:maternal specification of dorsal/ventral axis, oocyte, germ-line encoded; HMP:FlyBase.
DR GO; GO:0061355; P:Wnt protein secretion; IMP:FlyBase.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255, ECO:0000312|FlyBase:FBgn0045866"
FT CHAIN 21..206
FT /note="Transmembrane emp24 domain-containing protein bai"
FT /evidence="ECO:0000312|FlyBase:FBgn0045866"
FT /id="PRO_0000393917"
FT TOPO_DOM 21..172
FT /note="Lumenal"
FT /evidence="ECO:0000255, ECO:0000312|FlyBase:FBgn0045866"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..206
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255, ECO:0000312|FlyBase:FBgn0045866"
FT DOMAIN 30..140
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096,
FT ECO:0000312|FlyBase:FBgn0045866"
FT VARIANT 14
FT /note="C -> S (in strain: ZBMEL131)"
FT /evidence="ECO:0000269|PubMed:16951084"
FT VARIANT 60
FT /note="I -> V (in strain: MEL18 and MEL20)"
FT /evidence="ECO:0000269|PubMed:19126864"
FT VARIANT 95
FT /note="I -> T (in strain: ZBMEL82)"
FT /evidence="ECO:0000269|PubMed:16951084"
FT VARIANT 106
FT /note="I -> V (in strain: MEL11, MEL12, ZBMEL82, ZBMEL131,
FT ZBMEL186, ZBMEL191 and ZBMEL229)"
FT /evidence="ECO:0000269|PubMed:16951084,
FT ECO:0000269|PubMed:19126864"
SQ SEQUENCE 206 AA; 23692 MW; 97289D8AC3BD15CE CRC64;
MARAAFIVCL LMACAWSSHA VMFKLSPNTQ KCLKEDIQAN QLVMGEFEVS DVPGQIIDYI
ARDTKGHILS QKEHITKGKF SFMSEVYDTY EICFISKVPA HQRGVIQEVS LLTKKGVETK
SYEGIGEASK LKPLEVDLKR LEDLSDSIVR DFVLMRKREE EMRDTNEKTN SRVLFFSIFS
MCCLLGLATW QVLYLRRYFK AKKLIE
