ID   TMEDA_DROSI             Reviewed;         206 AA.
AC   A0AQ71;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Transmembrane emp24 domain-containing protein bai {ECO:0000250|UniProtKB:Q8SXY6};
DE   Flags: Precursor;
GN   Name=bai {ECO:0000250|UniProtKB:Q8SXY6}; ORFNames=GD21160;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:CAL26795.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Eca and bai are essential, though not redundant, for
CC       dorsoventral patterning of the embryo. Specifically required during
CC       early embryogenesis for the activity of maternal tkv, while the zygotic
CC       tkv is not affected (By similarity). {ECO:0000250|UniProtKB:Q8SXY6}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000255}.
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DR   EMBL; AM294809; CAL26795.1; -; Genomic_DNA.
DR   EMBL; CM000364; EDX14330.1; -; Genomic_DNA.
DR   RefSeq; XP_002104827.1; XM_002104791.2.
DR   AlphaFoldDB; A0AQ71; -.
DR   SMR; A0AQ71; -.
DR   STRING; 7240.A0AQ71; -.
DR   EnsemblMetazoa; FBtr0221070; FBpp0219562; FBgn0192611.
DR   GeneID; 6729519; -.
DR   HOGENOM; CLU_066963_3_1_1; -.
DR   OMA; AMGNDYH; -.
DR   PhylomeDB; A0AQ71; -.
DR   ChiTaRS; bai; fly.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0192611; Expressed in embryo and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038024; F:cargo receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0061355; P:Wnt protein secretion; IEA:EnsemblMetazoa.
DR   InterPro; IPR015720; Emp24-like.
DR   InterPro; IPR009038; GOLD_dom.
DR   PANTHER; PTHR22811; PTHR22811; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..206
FT                   /note="Transmembrane emp24 domain-containing protein bai"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000393920"
FT   TOPO_DOM        21..172
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..206
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..140
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ   SEQUENCE   206 AA;  23708 MW;  0728172241052E87 CRC64;
     MARAAFIVCL LMACAWSSHA VMFKLSPNTQ KCLKEDIQAN QLVMGEYEVS DVPGQIIDYI
     ARDTKGHILS QKEHITKGKF SFMSEVYETY EICFISKVPA HQRGVVQEVS LLTKKGVETK
     SYEGIGEASK LKPLEVDLKR LEDLSDSIVR DFVLMRKREE EMRDTNEKTN SRVLFFSIFS
     MCCLLGLATW QVLYLRRYFK AKKLIE