ID   BTBD3_CALJA             Reviewed;         522 AA.
AC   F7ASZ0; F7HEN6;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=BTB/POZ domain-containing protein 3;
GN   Name=BTBD3;
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, Cerebellum, Hippocampus, and Urinary bladder;
RX   PubMed=25243066; DOI=10.1186/2047-217x-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B. Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT   sequences.";
RL   Gigascience 3:14-14(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=24179155; DOI=10.1126/science.1244505;
RA   Matsui A., Tran M., Yoshida A.C., Kikuchi S.S., U M., Ogawa M.,
RA   Shimogori T.;
RT   "BTBD3 controls dendrite orientation toward active axons in mammalian
RT   neocortex.";
RL   Science 342:1114-1118(2013).
CC   -!- FUNCTION: Acts as a key regulator of dendritic field orientation during
CC       development of sensory cortex. Also directs dendrites toward active
CC       axon terminals when ectopically expressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Translocates from the cytosol to the nucleus in
CC       response to neuronal activity. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in the primary visual cortex.
CC       {ECO:0000269|PubMed:24179155}.
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DR   EMBL; GAMT01001310; JAB10551.1; -; mRNA.
DR   EMBL; GAMS01004918; JAB18218.1; -; mRNA.
DR   EMBL; GAMR01003066; JAB30866.1; -; mRNA.
DR   EMBL; GAMP01000191; JAB52564.1; -; mRNA.
DR   EMBL; ACFV01035945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002747409.3; XM_002747363.3.
DR   AlphaFoldDB; F7ASZ0; -.
DR   SMR; F7ASZ0; -.
DR   STRING; 9483.ENSCJAP00000046277; -.
DR   GeneID; 100385566; -.
DR   KEGG; cjc:100385566; -.
DR   CTD; 22903; -.
DR   eggNOG; KOG2075; Eukaryota.
DR   InParanoid; F7ASZ0; -.
DR   OMA; GADHNIQ; -.
DR   OrthoDB; 660286at2759; -.
DR   TreeFam; TF106482; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   Bgee; ENSCJAG00000058374; Expressed in cerebellum and 6 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0021987; P:cerebral cortex development; ISS:UniProtKB.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   Gene3D; 2.60.120.820; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR012983; PHR.
DR   InterPro; IPR038648; PHR_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF08005; PHR; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Neurogenesis; Nucleus; Reference proteome.
FT   CHAIN           1..522
FT                   /note="BTB/POZ domain-containing protein 3"
FT                   /id="PRO_0000425204"
FT   DOMAIN          120..190
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          235..300
FT                   /note="BACK"
SQ   SEQUENCE   522 AA;  58358 MW;  97A1674CB82ABF68 CRC64;
     MVDDKEKNMK CLTFFLMLPE TVKNRSKKSS KKANTGSSSS NSSKLPPVCY EIITLKTKKK
     KMAADIFPRK KPANSSSTSV QQYHQQNLSN NNLIPAPNWQ GLYPTIRERN AVMFNNDLMA
     DVHFVVGPPG GTQRLPGHKY VLAVGSSVFH AMFYGELAED KDEIRIPDVE PAAFLAMLKY
     IYCDEIDLAA DTVLATLYAA KKYIVPHLAR ACVNFLETSL SAKNACVLLS QSCLFEEPDL
     TQRCWEVIDA QAELALKSEG FCDIDFQTLE SILRRETLNA KEIVVFEAAL NWAEVECQRQ
     DLALSIENKR KVLGKALYLI RIPTMALDDF ANGAAQSGVL TLNETNDIFL WYTAAKKPEL
     QFVSKARKGL VPQRCHRFQS CAYRSNQWRY RGRCDSIQFA VDKRVFIAGF GLYGSSCGSA
     EYSAKIELKR QGVVLGQNLS KYFSDGSSNT FPVWFEYPVQ IEPDTFYTAS VILDGNELSY
     FGQEGMTEVQ CGKVTVQFQC SSDSTNGTGV QGGQIPELIF YA