TMEDB_DICDI
ID TMEDB_DICDI Reviewed; 209 AA.
AC Q54BN0; Q769F8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Transmembrane emp24 domain-containing protein B;
DE Flags: Precursor;
GN Name=empB; ORFNames=DDB_G0293540;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX4;
RA Morio T., Kuwabara Y., Sawayama M., Kuwayama H., Kawabae Y., Tanaka Y.;
RT "Regulation of development by Ddp24 genes, a family of genes involved in
RT COPI/II-coated vesicle trafficking.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Could have a role in the budding of coatomer-coated and other
CC species of coated vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; AB112542; BAD05161.1; -; Genomic_DNA.
DR EMBL; AAFI02000218; EAL60582.1; -; Genomic_DNA.
DR RefSeq; XP_628999.1; XM_628997.1.
DR AlphaFoldDB; Q54BN0; -.
DR SMR; Q54BN0; -.
DR STRING; 44689.DDB0215389; -.
DR PaxDb; Q54BN0; -.
DR EnsemblProtists; EAL60582; EAL60582; DDB_G0293540.
DR GeneID; 8629283; -.
DR KEGG; ddi:DDB_G0293540; -.
DR dictyBase; DDB_G0293540; empB.
DR eggNOG; KOG1692; Eukaryota.
DR HOGENOM; CLU_066963_4_1_1; -.
DR InParanoid; Q54BN0; -.
DR OMA; NAEDCFY; -.
DR PhylomeDB; Q54BN0; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q54BN0; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Membrane; Protein transport; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..209
FT /note="Transmembrane emp24 domain-containing protein B"
FT /id="PRO_0000342023"
FT TOPO_DOM 25..174
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..119
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT CONFLICT 2
FT /note="N -> D (in Ref. 1; BAD05161)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 209 AA; 23798 MW; A745C057B88604EB CRC64;
MNKTNQLINI CILVTLFLIG SSSALTLQVE PKSQECFYNF IESGKTSLLL YQVIRGGLLD
INVKLTDPKG NTIFERLHFD TQMKGKQSFT AGESGAYKVC FNNEMSRFTA KVVTFTWASE
EEGVKEVAKG DSITPMDQSV QKIERVLQSV IHEQKKLRYR EQANRDTSES TNARVVWWTI
AEVIVLVVMG VGQIWYLRKW FDNKSTGRV
