ID   TMEDE_DROGR             Reviewed;         216 AA.
AC   B4JG34;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Transmembrane emp24 domain-containing protein eca {ECO:0000250|UniProtKB:Q8SXY6};
DE   Flags: Precursor;
GN   Name=eca {ECO:0000250|UniProtKB:Q8SXY6}; ORFNames=GH18190;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDV93601.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV93601.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Eca and bai are essential, though not redundant, for
CC       dorsoventral patterning of the embryo. Specifically required during
CC       early embryogenesis for the activity of maternal tkv, while the zygotic
CC       tkv is not affected. Involved in Golgi organization (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000255}.
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DR   EMBL; CH916369; EDV93601.1; -; Genomic_DNA.
DR   RefSeq; XP_001990539.1; XM_001990503.1.
DR   AlphaFoldDB; B4JG34; -.
DR   SMR; B4JG34; -.
DR   STRING; 7222.FBpp0152096; -.
DR   EnsemblMetazoa; FBtr0153604; FBpp0152096; FBgn0125658.
DR   GeneID; 6563509; -.
DR   KEGG; dgr:6563509; -.
DR   eggNOG; KOG1690; Eukaryota.
DR   HOGENOM; CLU_066963_2_2_1; -.
DR   InParanoid; B4JG34; -.
DR   OMA; STAIKWS; -.
DR   OrthoDB; 1294924at2759; -.
DR   PhylomeDB; B4JG34; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   InterPro; IPR015720; Emp24-like.
DR   InterPro; IPR009038; GOLD_dom.
DR   PANTHER; PTHR22811; PTHR22811; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..216
FT                   /note="Transmembrane emp24 domain-containing protein eca"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000393926"
FT   TOPO_DOM        21..183
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..126
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT   COILED          134..164
FT                   /evidence="ECO:0000255"
FT   MOTIF           213..216
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   216 AA;  25133 MW;  1D48C98C5EA206A0 CRC64;
     MRNQLICLAL MLCALHSASG LYFHISETER KCFIEEVPDE TTVIVNYKVE LYDPRSNGFM
     PSSPGIGMHV EVRDSDDKVI LSRVYSSQGR ISFTSHTPGE HVICMYSNST AWFNGAQLRV
     HLDIQVGEHA IDYANVAQKE KLTELQLRIR QLLDQVQQIT KEQNYQRYRE ERFRHTSEST
     NSRVLWWSLA QTVVLVCMGF WQMRHLKSFF EAKKLV