BTBD3_MOUSE
ID BTBD3_MOUSE Reviewed; 530 AA.
AC P58545; Q6P5B8;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=BTB/POZ domain-containing protein 3;
GN Name=Btbd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=24179155; DOI=10.1126/science.1244505;
RA Matsui A., Tran M., Yoshida A.C., Kikuchi S.S., U M., Ogawa M.,
RA Shimogori T.;
RT "BTBD3 controls dendrite orientation toward active axons in mammalian
RT neocortex.";
RL Science 342:1114-1118(2013).
CC -!- FUNCTION: Acts as a key regulator of dendritic field orientation during
CC development of sensory cortex. Also directs dendrites toward active
CC axon terminals when ectopically expressed.
CC {ECO:0000269|PubMed:24179155}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24179155}.
CC Nucleus {ECO:0000269|PubMed:24179155}. Note=Translocates from the
CC cytosol to the nucleus in response to neuronal activity.
CC -!- TISSUE SPECIFICITY: In the somatosensory cortex, specifically expressed
CC in spiny stellate neurons during barrel formation. Also expressed in
CC the olfactory bulb, piriform cortex and hippocampus.
CC {ECO:0000269|PubMed:24179155}.
CC -!- DEVELOPMENTAL STAGE: Not expressed in early postnatal somatosensory
CC cortex at postnatal day 1 (P1): weakly expressed at P2, coincident with
CC innervation by thalamocortical axons into layer IV cortex, followed by
CC a barrel-like expression pattern established over the next few days.
CC {ECO:0000269|PubMed:24179155}.
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DR EMBL; AL772205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL935129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL28399.1; -; Genomic_DNA.
DR EMBL; BC018174; AAH18174.1; -; mRNA.
DR EMBL; BC062968; AAH62968.1; -; mRNA.
DR CCDS; CCDS16798.1; -.
DR RefSeq; NP_001020602.1; NM_001025431.1.
DR RefSeq; NP_663509.2; NM_145534.2.
DR AlphaFoldDB; P58545; -.
DR SMR; P58545; -.
DR BioGRID; 230751; 2.
DR STRING; 10090.ENSMUSP00000074864; -.
DR iPTMnet; P58545; -.
DR PhosphoSitePlus; P58545; -.
DR PaxDb; P58545; -.
DR PRIDE; P58545; -.
DR ProteomicsDB; 273710; -.
DR Antibodypedia; 8935; 139 antibodies from 22 providers.
DR DNASU; 228662; -.
DR Ensembl; ENSMUST00000075410; ENSMUSP00000074864; ENSMUSG00000062098.
DR GeneID; 228662; -.
DR KEGG; mmu:228662; -.
DR UCSC; uc008mpa.1; mouse.
DR CTD; 22903; -.
DR MGI; MGI:2385155; Btbd3.
DR VEuPathDB; HostDB:ENSMUSG00000062098; -.
DR eggNOG; KOG2075; Eukaryota.
DR GeneTree; ENSGT00940000156461; -.
DR InParanoid; P58545; -.
DR OrthoDB; 660286at2759; -.
DR PhylomeDB; P58545; -.
DR TreeFam; TF106482; -.
DR BioGRID-ORCS; 228662; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Btbd3; mouse.
DR PRO; PR:P58545; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P58545; protein.
DR Bgee; ENSMUSG00000062098; Expressed in cerebellum lobe and 269 other tissues.
DR ExpressionAtlas; P58545; baseline and differential.
DR Genevisible; P58545; MM.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0021987; P:cerebral cortex development; IMP:UniProtKB.
DR GO; GO:0048813; P:dendrite morphogenesis; IDA:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR Gene3D; 2.60.120.820; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR012983; PHR.
DR InterPro; IPR038648; PHR_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF08005; PHR; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Neurogenesis; Nucleus; Reference proteome.
FT CHAIN 1..530
FT /note="BTB/POZ domain-containing protein 3"
FT /id="PRO_0000186212"
FT DOMAIN 128..198
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 243..308
FT /note="BACK"
FT REGION 23..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 90
FT /note="Q -> QQH (in Ref. 1; AAH18174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 530 AA; 58802 MW; 6069FF5FF6F3C1EC CRC64;
MVDDKEKNMK CLTFFLMLPE TVKNRSKKGS KKANSSGGGG GGGSVGSGSS KLPPVCYEII
TLKTKKKKKM AADIFPRKKP ANSSSTTVQQ QHQHNLCNNN LIPAPNWQGL YPTIRERNAV
MFNNDLMADV HFVVGPPGGT QRLPGHKYVL AVGSSVFHAM FYGELAEDKD EIRIPDVEPA
AFLAMLKYIY CDEIDLAADT VLATLYAAKK YIVPHLARAC VNFLETSLSA KNACVLLSQS
CLFEEPDLTQ RCWEVIDAQA ELALKSEGFC DIDFQTLESI LRRETLNAKE IVVFEAALNW
AEVECQRQDL ALSIENKRKV LGKALYLIRI PTMALDDFAN GAAQSGVLTL NETNDIFLWY
TASKKPELQF VSKARKGLVP QRCHRFQSCA YRSNQWRYRG RCDSIQFAVD KRVFIAGFGL
YGSSCGSAEY SAKIELKRQG VVLGQNLSKY FSDGSSNTFP VWFEYPVQIE PDTFYTASVV
LDGNELSYFG QEGMTEVQCG KVTVQFQCSS DSTNGTGVQG GQIPELIFYA
