TMED_NEMVE
ID TMED_NEMVE Reviewed; 203 AA.
AC A7SXK3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Transmembrane emp24 domain-containing protein;
DE Flags: Precursor;
GN ORFNames=v1g194562;
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6;
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Could have a role in the budding of coatomer-coated and other
CC species of coated vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; DS469890; EDO31547.1; -; Genomic_DNA.
DR RefSeq; XP_001623647.1; XM_001623597.1.
DR AlphaFoldDB; A7SXK3; -.
DR SMR; A7SXK3; -.
DR STRING; 45351.EDO31547; -.
DR EnsemblMetazoa; EDO31547; EDO31547; NEMVEDRAFT_v1g194562.
DR GeneID; 5502470; -.
DR KEGG; nve:5502470; -.
DR eggNOG; KOG1692; Eukaryota.
DR HOGENOM; CLU_066963_4_1_1; -.
DR InParanoid; A7SXK3; -.
DR OMA; WNLFVIG; -.
DR OrthoDB; 1328081at2759; -.
DR PhylomeDB; A7SXK3; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Membrane; Protein transport; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..203
FT /note="Transmembrane emp24 domain-containing protein"
FT /id="PRO_0000342024"
FT TOPO_DOM 23..170
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..114
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ SEQUENCE 203 AA; 23147 MW; 110C55B6440A7F52 CRC64;
MASIRLLPSC IVLMFLARSS LCYFITIDAH GEECFHDKVT SGTKMGLIFE VAEGGFLDID
VKIIGPDQKV IYSGERETSG KYTFAAHMDG TYNYCFSNKM STMTPKVLKF SMDIGEAPKD
TSKEDNAGHD KLSEMVSQLS EAMTGVKHEQ EYMEVRERIH RSINDNTNSR VVWWSFFESL
VLVAMTLGQV YYLKRFFEVR RVV
