TMEM9_HUMAN
ID TMEM9_HUMAN Reviewed; 183 AA.
AC Q9P0T7; B1ALM6; Q96NQ9; Q9BQF5;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Proton-transporting V-type ATPase complex assembly regulator TMEM9 {ECO:0000305|PubMed:30374053};
DE Short=v-ATPase assembly regulator TMEM9 {ECO:0000305|PubMed:30374053};
DE AltName: Full=Dermal papilla-derived protein 4 {ECO:0000303|Ref.2};
DE AltName: Full=Transmembrane protein 9 {ECO:0000303|PubMed:12359240};
DE Short=Protein TMEM9 {ECO:0000303|PubMed:12359240};
DE Flags: Precursor;
GN Name=TMEM9 {ECO:0000312|HGNC:HGNC:18823};
GN Synonyms=DERP4 {ECO:0000303|Ref.2}, TMEM9A;
GN ORFNames=HSPC186, PSEC0012, UNQ631/PRO1248;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP GLYCOSYLATIONS AT ASN-21; ASN-38 AND ASN-47.
RX PubMed=12359240; DOI=10.1016/s0006-291x(02)02228-3;
RA Kveine M., Tenstad E., Dosen G., Funderud S., Rian E.;
RT "Characterization of the novel human transmembrane protein 9 (TMEM9) that
RT localizes to lysosomes and late endosomes.";
RL Biochem. Biophys. Res. Commun. 297:912-917(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair follicle dermal papilla;
RA Ikeda A., Yoshimoto M.;
RT "Molecular cloning of a dermal papilla derived gene.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137 AND SER-144, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [17]
RP FUNCTION, INTERACTION WITH ATP6AP2 AND ATP6V0D1, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DOMAIN.
RX PubMed=30374053; DOI=10.1038/s41556-018-0219-8;
RA Jung Y.S., Jun S., Kim M.J., Lee S.H., Suh H.N., Lien E.M., Jung H.Y.,
RA Lee S., Zhang J., Yang J.I., Ji H., Wu J.Y., Wang W., Miller R.K., Chen J.,
RA McCrea P.D., Kopetz S., Park J.I.;
RT "TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated
RT Wnt/beta-catenin signalling.";
RL Nat. Cell Biol. 20:1421-1433(2018).
RN [18]
RP FUNCTION.
RX PubMed=32380568; DOI=10.1002/hep.31305;
RA Jung Y.S., Stratton S.A., Lee S.H., Kim M.J., Jun S., Zhang J., Zheng B.,
RA Cervantes C.L., Cha J.H., Barton M.C., Park J.I.;
RT "TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling via APC Lysosomal
RT Degradation for Liver Regeneration and Tumorigenesis.";
RL Hepatology 73:776-794(2021).
CC -!- FUNCTION: Transmembrane protein that binds to and facilitates the
CC assembly of lysosomal proton-transporting V-type ATPase (v-ATPase),
CC resulting in enhanced lysosomal acidification and trafficking
CC (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2
CC and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex
CC formation and activation (PubMed:30374053). TMEM9-controlled vesicular
CC acidification induces hyperactivation of Wnt/beta-catenin signaling,
CC involved in development, tissue homeostasis and tissue regeneration,
CC through lysosomal degradation of adenomatous polyposis coli/APC
CC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic
CC regeneration (PubMed:32380568). {ECO:0000269|PubMed:30374053,
CC ECO:0000269|PubMed:32380568}.
CC -!- SUBUNIT: Interacts with the v-ATPase accessory protein ATP6AP2 and with
CC the v-ATPase complex subunit ATP6V0D1; these interactions lead to the
CC assembly of the v-ATPase complex. {ECO:0000269|PubMed:30374053}.
CC -!- INTERACTION:
CC Q9P0T7; P27449: ATP6V0C; NbExp=3; IntAct=EBI-723976, EBI-721179;
CC Q9P0T7; O14523: C2CD2L; NbExp=3; IntAct=EBI-723976, EBI-12822627;
CC Q9P0T7; O95832: CLDN1; NbExp=3; IntAct=EBI-723976, EBI-723889;
CC Q9P0T7; P78369: CLDN10; NbExp=3; IntAct=EBI-723976, EBI-13372810;
CC Q9P0T7; P54849: EMP1; NbExp=3; IntAct=EBI-723976, EBI-4319440;
CC Q9P0T7; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-723976, EBI-10317425;
CC Q9P0T7; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-723976, EBI-12092917;
CC Q9P0T7; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-723976, EBI-10262251;
CC Q9P0T7; O43752: STX6; NbExp=3; IntAct=EBI-723976, EBI-2695795;
CC Q9P0T7; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-723976, EBI-2844246;
CC Q9P0T7; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-723976, EBI-2852148;
CC Q9P0T7; P30536: TSPO; NbExp=3; IntAct=EBI-723976, EBI-6623146;
CC Q9P0T7; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-723976, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:12359240,
CC ECO:0000305|PubMed:30374053}; Single-pass type I membrane protein
CC {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:12359240,
CC ECO:0000269|PubMed:30374053}; Single-pass type I membrane protein
CC {ECO:0000255}. Endosome, multivesicular body membrane
CC {ECO:0000269|PubMed:30374053}; Single-pass type I membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Highly expressed in adrenal gland, thyroid gland,
CC testis, ovary and prostate (PubMed:12359240). Moderate expression in
CC trachea, spinal cord, stomach, colon, small intestine and spleen
CC (PubMed:12359240, PubMed:30374053). Low expression in bone marrow,
CC lymph node, thymus and peripheral blood lymphocytes (PubMed:12359240).
CC Expression is detected in hematopoietic cell lines including those of
CC myeloid, erythroid, B- and T-cell origin (PubMed:12359240).
CC {ECO:0000269|PubMed:12359240, ECO:0000269|PubMed:30374053}.
CC -!- DOMAIN: The transmembrane domain (TMD) is essential for the interaction
CC with ATP6AP2. {ECO:0000269|PubMed:30374053}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:12359240}.
CC -!- SIMILARITY: Belongs to the TMEM9 family. {ECO:0000305}.
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DR EMBL; AY138587; AAN15925.1; -; mRNA.
DR EMBL; AB013909; BAB87799.1; -; mRNA.
DR EMBL; AF151020; AAF36106.1; -; mRNA.
DR EMBL; AL136600; CAB66535.1; -; mRNA.
DR EMBL; AY359012; AAQ89371.1; -; mRNA.
DR EMBL; AK054883; BAB70820.1; -; mRNA.
DR EMBL; AK075335; BAC11554.1; -; mRNA.
DR EMBL; AL139159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91338.1; -; Genomic_DNA.
DR EMBL; BC001106; AAH01106.1; -; mRNA.
DR CCDS; CCDS1408.1; -.
DR RefSeq; NP_001275493.1; NM_001288564.1.
DR RefSeq; NP_001275494.1; NM_001288565.1.
DR RefSeq; NP_001275495.1; NM_001288566.1.
DR RefSeq; NP_001275496.1; NM_001288567.1.
DR RefSeq; NP_001275497.1; NM_001288568.1.
DR RefSeq; NP_001275498.1; NM_001288569.1.
DR RefSeq; NP_001275499.1; NM_001288570.1.
DR RefSeq; NP_001275500.1; NM_001288571.1.
DR RefSeq; NP_057540.1; NM_016456.4.
DR RefSeq; XP_011507687.1; XM_011509385.1.
DR RefSeq; XP_011507688.1; XM_011509386.2.
DR RefSeq; XP_011507689.1; XM_011509387.2.
DR AlphaFoldDB; Q9P0T7; -.
DR BioGRID; 128927; 265.
DR IntAct; Q9P0T7; 21.
DR MINT; Q9P0T7; -.
DR STRING; 9606.ENSP00000356301; -.
DR TCDB; 8.A.123.1.1; the cytokine expression and secretion mediator and v-type atpase regulator, tmem9 (tmem9) family.
DR GlyConnect; 1857; 1 N-Linked glycan (1 site).
DR GlyGen; Q9P0T7; 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site).
DR iPTMnet; Q9P0T7; -.
DR PhosphoSitePlus; Q9P0T7; -.
DR BioMuta; TMEM9; -.
DR DMDM; 20532090; -.
DR EPD; Q9P0T7; -.
DR jPOST; Q9P0T7; -.
DR MassIVE; Q9P0T7; -.
DR MaxQB; Q9P0T7; -.
DR PaxDb; Q9P0T7; -.
DR PeptideAtlas; Q9P0T7; -.
DR PRIDE; Q9P0T7; -.
DR ProteomicsDB; 83596; -.
DR Antibodypedia; 34497; 62 antibodies from 19 providers.
DR DNASU; 252839; -.
DR Ensembl; ENST00000367330.6; ENSP00000356299.1; ENSG00000116857.17.
DR Ensembl; ENST00000367333.6; ENSP00000356302.2; ENSG00000116857.17.
DR Ensembl; ENST00000367334.9; ENSP00000356303.5; ENSG00000116857.17.
DR Ensembl; ENST00000485839.6; ENSP00000476893.1; ENSG00000116857.17.
DR GeneID; 252839; -.
DR KEGG; hsa:252839; -.
DR MANE-Select; ENST00000367330.6; ENSP00000356299.1; NM_001288565.2; NP_001275494.1.
DR UCSC; uc001gvx.5; human.
DR CTD; 252839; -.
DR DisGeNET; 252839; -.
DR GeneCards; TMEM9; -.
DR HGNC; HGNC:18823; TMEM9.
DR HPA; ENSG00000116857; Low tissue specificity.
DR MIM; 616877; gene.
DR neXtProt; NX_Q9P0T7; -.
DR OpenTargets; ENSG00000116857; -.
DR PharmGKB; PA38696; -.
DR VEuPathDB; HostDB:ENSG00000116857; -.
DR eggNOG; KOG4007; Eukaryota.
DR GeneTree; ENSGT00390000000819; -.
DR HOGENOM; CLU_093267_2_0_1; -.
DR InParanoid; Q9P0T7; -.
DR OMA; YNRNFSQ; -.
DR OrthoDB; 1380345at2759; -.
DR PhylomeDB; Q9P0T7; -.
DR TreeFam; TF315146; -.
DR PathwayCommons; Q9P0T7; -.
DR SignaLink; Q9P0T7; -.
DR BioGRID-ORCS; 252839; 14 hits in 1086 CRISPR screens.
DR ChiTaRS; TMEM9; human.
DR GeneWiki; TMEM9; -.
DR GenomeRNAi; 252839; -.
DR Pharos; Q9P0T7; Tbio.
DR PRO; PR:Q9P0T7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9P0T7; protein.
DR Bgee; ENSG00000116857; Expressed in cingulate cortex and 184 other tissues.
DR ExpressionAtlas; Q9P0T7; baseline and differential.
DR Genevisible; Q9P0T7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045171; C:intercellular bridge; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005770; C:late endosome; IDA:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR GO; GO:0005764; C:lysosome; IDA:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
DR GO; GO:0072686; C:mitotic spindle; IDA:HPA.
DR GO; GO:0032585; C:multivesicular body membrane; IDA:UniProtKB.
DR GO; GO:0048388; P:endosomal lumen acidification; IDA:UniProtKB.
DR GO; GO:0007042; P:lysosomal lumen acidification; IDA:UniProtKB.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0070070; P:proton-transporting V-type ATPase complex assembly; IDA:UniProtKB.
DR GO; GO:0042176; P:regulation of protein catabolic process; ISS:UniProtKB.
DR InterPro; IPR008853; TMEM9/TMEM9B.
DR PANTHER; PTHR13064; PTHR13064; 1.
DR Pfam; PF05434; Tmemb_9; 1.
PE 1: Evidence at protein level;
KW Endosome; Glycoprotein; Lysosome; Membrane; Phosphoprotein;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..183
FT /note="Proton-transporting V-type ATPase complex assembly
FT regulator TMEM9"
FT /id="PRO_0000034374"
FT TOPO_DOM 21..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 22
FT /note="K -> KVRE (in Ref. 6; BAB70820)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="C -> CCS (in Ref. 4; CAB66535)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 183 AA; 20574 MW; 6BC020EC9FE7F70E CRC64;
MKLLSLVAVV GCLLVPPAEA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ KDCNCLHVVE
PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG ALLLYMAFLM LVDPLIRKPD
AYTEQLHNEE ENEDARSMAA AAASLGGPRA NTVLERVEGA QQRWKLQVQE QRKTVFDRHK
MLS
