ID   BTBD3_MUSPF             Reviewed;         532 AA.
AC   M3XQV7; M1EGD6;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 2.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=BTB/POZ domain-containing protein 3;
GN   Name=BTBD3;
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Mustela.
OX   NCBI_TaxID=9669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420;
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., Przyblyski D.,
RA   Ribeiro F., Russell P., Sharpe T., Turner-Maier J., Walker B.J., Young S.,
RA   Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 44-532.
RC   TISSUE=Lung;
RX   PubMed=23236062; DOI=10.1128/jvi.02476-12;
RA   Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA   Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA   Farooqui A., Kelvin D.J.;
RT   "Sequencing, annotation, and characterization of the influenza ferret
RT   infectome.";
RL   J. Virol. 87:1957-1966(2013).
RN   [3]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=24179155; DOI=10.1126/science.1244505;
RA   Matsui A., Tran M., Yoshida A.C., Kikuchi S.S., U M., Ogawa M.,
RA   Shimogori T.;
RT   "BTBD3 controls dendrite orientation toward active axons in mammalian
RT   neocortex.";
RL   Science 342:1114-1118(2013).
CC   -!- FUNCTION: Acts as a key regulator of dendritic field orientation during
CC       development of sensory cortex. Also directs dendrites toward active
CC       axon terminals when ectopically expressed.
CC       {ECO:0000269|PubMed:24179155}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Translocates from the cytosol to the nucleus in
CC       response to neuronal activity. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in visual cortex. Expressed in visual
CC       cortex layer IV neurons. {ECO:0000269|PubMed:24179155}.
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DR   EMBL; AEYP01035982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JP006639; AER95236.1; -; mRNA.
DR   RefSeq; XP_004754269.1; XM_004754212.2.
DR   AlphaFoldDB; M3XQV7; -.
DR   SMR; M3XQV7; -.
DR   STRING; 9668.ENSMPUP00000001457; -.
DR   GeneID; 101682009; -.
DR   KEGG; mpuf:101682009; -.
DR   CTD; 22903; -.
DR   eggNOG; KOG2075; Eukaryota.
DR   HOGENOM; CLU_015899_2_1_1; -.
DR   InParanoid; M3XQV7; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0021987; P:cerebral cortex development; ISS:UniProtKB.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   Gene3D; 2.60.120.820; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR012983; PHR.
DR   InterPro; IPR038648; PHR_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF08005; PHR; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Neurogenesis; Nucleus; Reference proteome.
FT   CHAIN           1..532
FT                   /note="BTB/POZ domain-containing protein 3"
FT                   /id="PRO_0000425205"
FT   DOMAIN          130..200
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          245..310
FT                   /note="BACK"
FT   REGION          23..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  59163 MW;  411393FAB688A4C0 CRC64;
     MVDDKEKNMK CLTFFLMLPE TVKNRSKKSS KKTNTGGGGG GSSSSSSSSS NSKLPPVCYE
     IITLKTKKKK KMAADIFPRK KPANSSSTTV QQYHQQNLSN NNLIPAPNWQ GLYPTIRERN
     AVMFNNDLMA DVHFVVGPPG GTQRLPGHKY VLAVGSSVFH AMFYGELAED KDEIRIPDVE
     PAAFLAMLKY IYCDEIDLAA DTVLATLYAA KKYIVPHLAR ACVNFLETSL SAKNACVLLS
     QSCLFEEPDL TQRCWEVIDA QAELALKSEG FCDIDFQTLE SILRRETLNA KEIVVFEAAL
     NWAEVECQRQ DLALSIENKR KVLGKALYLI RIPTMALDDF ANGAAQSGVL TLNETNDIFL
     WYTAAKKPEL QFVSKARKGL VPQRCHRFQS CAYRSNQWRY RGRCDSIQFA VDKRVFIAGF
     GLYGSSCGSA EYSAKIELKR QGVVLGQNLS KYFSDGSSNT FPVWFEYPVQ IEPDTFYTAS
     VILDGNELSY FGQEGMTEVQ CGKVTVQFQC SSDSTNGTGV QGGQIPELIF YA